Publications by authors named "Geoffrey W G Sharp"

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Conversion of glutamate into proline by the leucine analog BCH enhances biphasic insulin secretion in pancreatic β-cells.
Sevda Gheibi, Luis Rodrigo Cataldo, Hamidreza Ardalani, Lisa Nocquet, Peter Spégel, Geoffrey W G Sharp

J Biol Chem· May 2025

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Fasting inhibits excitatory synaptic input on paraventricular oxytocin neurons neuropeptide Y and Y1 receptor, inducing rebound hyperphagia, and weight gain.
Lei Wang, Shigetomo Suyama, Samantha A Lee, Yoichi Ueta, Yutaka Seino, Geoffrey W G Sharp

Front Nutr· October 2022

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Onion component, isoalliin, stimulates feeding and activates the arcuate nucleus neuropeptide Y, ghrelin- and Ninjin'yoeito-responsive neurons.
Lei Wang, Wanxin Han, Yusaku Iwasaki, Rakhat Yermek, Geoffrey W G Sharp

Neuropeptides· October 2021

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Prostaglandin E1 inhibits endocytosis in the β-cell endocytosis.
Ying Zhao, Qinghua Fang, Susanne G Straub, Manfred Lindau, Geoffrey W G Sharp

J Endocrinol· June 2016

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CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.
Jonathan H Zippin, Yanqiu Chen, Susanne G Straub, Kenneth C Hess, Ana Diaz, Geoffrey W G Sharp

J Biol Chem· November 2013

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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.
Peter Spégel, Vladimir V Sharoyko, Isabel Goehring, Anders P H Danielsson, Siri Malmgren, Geoffrey W G Sharp

Biochem J· March 2013

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Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.
Susanne G Straub, Geoffrey W G Sharp

Am J Physiol Cell Physiol· June 2012

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Glucose stimulation of protein acylation in the pancreatic β-cell.
Mossaad Abdel-Ghany, Geoffrey W G Sharp, Susanne G Straub

Life Sci· December 2010

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Hormonal inhibition of endocytosis: novel roles for noradrenaline and G protein G(z).
Ying Zhao, Qinghua Fang, Susanne G Straub, Manfred Lindau, Geoffrey W G Sharp

J Physiol· September 2010

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Noradrenaline inhibits exocytosis via the G protein βγ subunit and refilling of the readily releasable granule pool via the α(i1/2) subunit.
Ying Zhao, Qinghua Fang, Susanne G Straub, Manfred Lindau, Geoffrey W G Sharp

J Physiol· September 2010

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Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.
Ying Zhao, Qinghua Fang, Susanne G Straub, Geoffrey W G Sharp

J Biol Chem· February 2008

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The inhibitors of protein acylation, cerulenin and tunicamycin, increase voltage-dependent Ca(2+) currents in the insulin-secreting INS 832/13 cell.
Ying Zhao, Geoffrey W G Sharp, Susanne G Straub

Biochem Pharmacol· July 2007

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Inhibitory role of Src family tyrosine kinases on Ca2+-dependent insulin release.
Haiying Cheng, Susanne G Straub, Geoffrey W G Sharp

Am J Physiol Endocrinol Metab· March 2007

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Inhibition of insulin secretion by cerulenin might be due to impaired glucose metabolism.
Susanne G Straub, Geoffrey W G Sharp

Diabetes Metab Res Rev· February 2007

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Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets.
Susanne G Straub, Geoffrey W G Sharp

Diabetes· December 2004

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Stimulation of insulin release by glucose is associated with an increase in the number of docked granules in the beta-cells of rat pancreatic islets.
Susanne G Straub, Geetha Shanmugam, Geoffrey W G Sharp

Diabetes· December 2004

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Anaplerotic input is sufficient to induce time-dependent potentiation of insulin release in rat pancreatic islets.
Subhadra C Gunawardana, Yi-Jia Liu, Michael J Macdonald, Susanne G Straub, Geoffrey W G Sharp

Am J Physiol Endocrinol Metab· November 2004

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Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion.
Susanne G Straub, Geoffrey W G Sharp

Am J Physiol Cell Physiol· September 2004

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Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2.
Haiying Cheng, Susanne G Straub, Geoffrey W G Sharp

Am J Physiol Endocrinol Metab· August 2003

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Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH.
Yi-Jia Liu, Haiying Cheng, Heather Drought, Michael J MacDonald, Geoffrey W G Sharp

Am J Physiol Endocrinol Metab· August 2003

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Glucose-stimulated signaling pathways in biphasic insulin secretion.
Susanne G Straub, Geoffrey W G Sharp

Diabetes Metab Res Rev· July 2003

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Stimulation of insulin secretion by denatonium, one of the most bitter-tasting substances known.
Susanne G Straub, Jennifer Mulvaney-Musa, Hiroki Yajima, Gregory A Weiland, Geoffrey W G Sharp

Diabetes· February 2003

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Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription.
Mitsuhiko Noda, Shigeo Yamashita, Noriko Takahashi, Kazuhiro Eto, Lin-Ming Shen, Geoffrey W G Sharp

J Biol Chem· November 2002

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A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release.
Samira Daniel, Mitsuhiko Noda, Richard A Cerione, Geoffrey W G Sharp

Biochemistry· July 2002

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Hyposmotic shock stimulates insulin secretion by two distinct mechanisms. Studies with the betaHC9 cell.
Susanne G Straub, Samira Daniel, Geoffrey W G Sharp

Am J Physiol Endocrinol Metab· May 2002

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