Publications by authors named "Geoffrey Warhurst"

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Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics.
Zubida M Al-Majdoub, Narciso Couto, Brahim Achour, Matthew D Harwood, Gordon Carlson, Geoffrey Warhurst

Clin Pharmacol Ther· April 2021

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Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine.
Narciso Couto, Zubida M Al-Majdoub, Stephanie Gibson, Pamela J Davies, Brahim Achour, Geoffrey Warhurst

Drug Metab Dispos· April 2020

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Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation.
Maria Glymenaki, Gurdeep Singh, Andrew Brass, Geoffrey Warhurst, Andrew J McBain

Inflamm Bowel Dis· June 2017

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Removal of Contaminant DNA by Combined UV-EMA Treatment Allows Low Copy Number Detection of Clinically Relevant Bacteria Using Pan-Bacterial Real-Time PCR.
Bruce Humphrey, Neil McLeod, Carrie Turner, J Mark Sutton, Paul M Dark, Geoffrey Warhurst

PLoS One· April 2016

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Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates With Estrone-3-Sulfate Transport in Caco-2.
Matthew D Harwood, Sibylle Neuhoff, Amin Rostami-Hodjegan, Geoffrey Warhurst

J Pharm Sci· April 2016

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In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells.
Matthew D Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R Russell, Gordon Carlson, Geoffrey Warhurst

Drug Metab Dispos· March 2016

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In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition.
Matthew D Harwood, Brahim Achour, Sibylle Neuhoff, Matthew R Russell, Gordon Carlson, Geoffrey Warhurst

Drug Metab Dispos· March 2016

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Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and systematic review.
Geoffrey Warhurst, Graham Dunn, Paul Chadwick, Bronagh Blackwood, Daniel McAuley

Health Technol Assess· May 2015

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Diagnostic accuracy of SeptiFast multi-pathogen real-time PCR in the setting of suspected healthcare-associated bloodstream infection.
Geoffrey Warhurst, Satanayarana Maddi, Graham Dunn, Murad Ghrew, Paul Chadwick

Intensive Care Med· January 2015

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Accuracy of LightCycler(®) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis.
Paul Dark, Bronagh Blackwood, Simon Gates, Danny McAuley, Gavin D Perkins, Geoffrey Warhurst

Intensive Care Med· January 2015

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Lost in centrifugation: accounting for transporter protein losses in quantitative targeted absolute proteomics.
Matthew D Harwood, Matthew R Russell, Sibylle Neuhoff, Geoffrey Warhurst, Amin Rostami-Hodjegan

Drug Metab Dispos· October 2014

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Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice.
Ekta K Bhardwaj, Kathryn J Else, Michael T Rogan, Geoffrey Warhurst

World J Gastroenterol· February 2014

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Accuracy of LightCycler(R) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review protocol.
Paul Dark, Claire Wilson, Bronagh Blackwood, Danny F McAuley, Gavin D Perkins, Geoffrey Warhurst

BMJ Open· October 2012

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Combined molecular gram typing and high-resolution melting analysis for rapid identification of a syndromic panel of bacteria responsible for sepsis-associated bloodstream infection.
Hani Ozbak, Paul Dark, Satyanarayana Maddi, Paul Chadwick, Geoffrey Warhurst

J Mol Diagn· June 2012

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Investigation of systemic and mesenteric inflammatory signaling and gut-derived endothelial toxicity in patients undergoing high-risk abdominal aortic surgery.
Leigh Willoughby, Paul Dark, Geoffrey Warhurst

Shock· August 2011

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The clinical diagnostic accuracy of rapid detection of healthcare-associated bloodstream infection in intensive care using multipathogen real-time PCR technology.
Paul Dark, Graham Dunn, Paul Chadwick, Duncan Young, Andrew Bentley, Geoffrey Warhurst

BMJ Open· June 2011

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Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection.
Paul M Dark, Paul Dean, Geoffrey Warhurst

Crit Care· January 2010

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Detecting sepsis-associated bloodstream infection acquired in intensive care using multi-pathogen real-time PCR.
Paul Dark, Paul Chadwick, Geoffrey Warhurst

J Infect· October 2009

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Potentiation of flagellin responses in gut epithelial cells by interferon-gamma is associated with STAT-independent regulation of MyD88 expression.
Ciara Bannon, Pam J Davies, Andrew Collett, Geoffrey Warhurst

Biochem J· September 2009

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Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(-/-) mice.
Andrew Collett, Norman B Higgs, Meritxell Gironella, Leo A H Zeef, Andy Hayes, Geoffrey Warhurst

Inflamm Bowel Dis· May 2008

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Characterisation of Escherichia coli strains involved in transcytosis across gut epithelial cells exposed to metabolic and inflammatory stress.
Christian Macutkiewicz, Gordon Carlson, Edwin Clark, Ulrich Dobrindt, Ian Roberts, Geoffrey Warhurst

Microbes Infect· April 2008

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Variability of bacterial translocation in the absence of intestinal mucosal damage following injury and the influence of interleukin-6.
Hirobumi Gunji, Sylvia Scarth, Gordon L Carlson, Geoffrey Warhurst, Rodney A Little

Pathophysiology· February 2006

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Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores.
Christopher J Watson, Catherine J Hoare, David R Garrod, Gordon L Carlson, Geoffrey Warhurst

J Cell Sci· November 2005

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Interferon gamma induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft-mediated process.
Edwin Clark, Catherine Hoare, Jolanta Tanianis-Hughes, Gordon L Carlson, Geoffrey Warhurst

Gastroenterology· May 2005

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