Publications by authors named "Geoffry L Curran"

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Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway.
Lushan Wang, Geoffry L Curran, Rui Zhong, Zheng Xue, Vaishnavi Veerareddy

J Cereb Blood Flow Metab· October 2025

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High-Density Lipoprotein Mimetic Peptide 4F Reduces Toxic Amyloid-Beta Exposure to the Blood-Brain Barrier Endothelium in Alzheimer's Disease Transgenic Mice.
Zengtao Wang, Rui Zhong, Geoffry L Curran, Paul Min, Val J Lowe

Mol Pharm· November 2024

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Metformin Prevents Tumor Cell Growth and Invasion of Human Hormone Receptor-Positive Breast Cancer (HR+ BC) Cells via Inhibition.
Christine Song, Dawa Jung, Ayse Tuba Kendi, Jin Kyung Rho, Eun-Joo Kim, Geoffry L Curran

Int J Mol Sci· July 2024

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Insulin Signaling Differentially Regulates the Trafficking of Insulin and Amyloid Beta Peptides at the Blood-Brain Barrier.
Andrew L Zhou, Suresh K Swaminathan, Vrishali S Salian, Lushan Wang, Geoffry L Curran

Mol Pharm· May 2024

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Deconvolution of Plasma Pharmacokinetics from Dynamic Heart Imaging Data Obtained by Single Positron Emission Computed Tomography/Computed Tomography Imaging.
Zengtao Wang, Lushan Wang, Malik Ebbini, Geoffry L Curran, Paul H Min

J Pharmacol Exp Ther· July 2023

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Age-Dependent Changes in the Plasma and Brain Pharmacokinetics of Amyloid-β Peptides and Insulin.
Andrew L Zhou, Nidhi Sharda, Vidur V Sarma, Kristen M Ahlschwede, Geoffry L Curran

J Alzheimers Dis· March 2022

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Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium.
Zengtao Wang, Nidhi Sharda, Geoffry L Curran, Ling Li, Val J Lowe

Mol Pharm· November 2021

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Distinct Uptake Kinetics of Alzheimer Disease Amyloid- 40 and 42 at the Blood-Brain Barrier Endothelium.
Nidhi Sharda, Kristen M Ahlschwede, Geoffry L Curran, Val J Lowe, Karunya K Kandimalla

J Pharmacol Exp Ther· March 2021

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High-Density Lipoprotein Mimetic Peptide 4F Efficiently Crosses the Blood-Brain Barrier and Modulates Amyloid- Distribution between Brain and Plasma.
Suresh K Swaminathan, Andrew L Zhou, Kristen M Ahlschwede, Geoffry L Curran, Val J Lowe

J Pharmacol Exp Ther· November 2020

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Apolipoprotein A-I Crosses the Blood-Brain Barrier through Clathrin-Independent and Cholesterol-Mediated Endocytosis.
Andrew L Zhou, Suresh K Swaminathan, Geoffry L Curran, Joseph F Poduslo, Val J Lowe

J Pharmacol Exp Ther· June 2019

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Cationic carrier peptide enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain.
Kristen M Ahlschwede, Geoffry L Curran, Jens T Rosenberg, Samuel C Grant, Gobinda Sarkar

Nanomedicine· February 2019

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Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain.
Suresh Kumar Swaminathan, Kristen M Ahlschwede, Vidur Sarma, Geoffry L Curran, Rajesh S Omtri

J Cereb Blood Flow Metab· May 2018

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Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.
Ming Xu, Elizabeth W Bradley, Megan M Weivoda, Soyun M Hwang, Tamar Pirtskhalava, Geoffry L Curran

J Gerontol A Biol Sci Med Sci· June 2017

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Peptide carrier-mediated non-covalent delivery of unmodified cisplatin, methotrexate and other agents via intravenous route to the brain.
Gobinda Sarkar, Geoffry L Curran, Jann N Sarkaria, Val J Lowe, Robert B Jenkins

PLoS One· January 2015

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Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits.
Edward K Agyare, Kristen M Jaruszewski, Geoffry L Curran, Jens T Rosenberg, Samuel C Grant

J Control Release· July 2014

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Multimodal nanoprobes to target cerebrovascular amyloid in Alzheimer's disease brain.
Kristen M Jaruszewski, Geoffry L Curran, Suresh K Swaminathan, Jens T Rosenberg, Samuel C Grant

Biomaterials· February 2014

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Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-β proteins in the cerebral vasculature.
Edward K Agyare, Sarah R Leonard, Geoffry L Curran, Caroline C Yu, Val J Lowe

Mol Pharm· May 2013

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A carrier for non-covalent delivery of functional beta-galactosidase and antibodies against amyloid plaques and IgM to the brain.
Gobinda Sarkar, Geoffry L Curran, Eric Mahlum, Teresa Decklever, Thomas M Wengenack

PLoS One· May 2012

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Designing nanoconjugates to effectively target pancreatic cancer cells in vitro and in vivo.
Jameel Ahmad Khan, Rachel A Kudgus, Annamaria Szabolcs, Shamit Dutta, Enfeng Wang, Geoffry L Curran

PLoS One· December 2011

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Efficient delivery of gold nanoparticles by dual receptor targeting.
Sanjib Bhattacharyya, Jameel Ahmad Khan, Geoffry L Curran, J David Robertson, Resham Bhattacharya

Adv Mater· November 2011

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Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.
Joseph F Poduslo, Kristi L Hultman, Geoffry L Curran, Gregory M Preboske, Ryan Chamberlain

J Neuropathol Exp Neurol· August 2011

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HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons.
Joseph F Poduslo, Emily J Gilles, Muthu Ramakrishnan, Kyle G Howell, Thomas M Wengenack, Geoffry L Curran

PLoS One· January 2010

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Reduced membrane lipids in the cortex of Alzheimer's disease transgenic mice.
Jeffrey K Yao, Thomas M Wengenack, Geoffry L Curran, Joseph F Poduslo

Neurochem Res· January 2009

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Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy.
Edward K Agyare, Geoffry L Curran, Muthu Ramakrishnan, Caroline C Yu, Joseph F Poduslo

Pharm Res· November 2008

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Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Abeta42 for magnetic resonance molecular imaging.
Muthu Ramakrishnan, Thomas M Wengenack, Karunya K Kandimalla, Geoffry L Curran, Emily J Gilles

Pharm Res· August 2008

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