Publications by authors named "George Bloom"

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Basic Science and Pathogenesis.
Evelyn Pardo, Vijay Kumar Sagar, Kelly Kim, Ammasi Periasamy, George S Bloom

Alzheimers Dement· December 2025

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The use of Benzonase to produce ribosome footprints simplifies translational levels quantification by Ribo-seq.
Guillermo Eastman, George S Bloom, José R Sotelo-Silveira

bioRxiv· March 2025

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Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neurons.
Evelyn Pardo, Taylor Kim, Horst Wallrabe, Kristine E Zengeler, Vijay Kumar Sagar, George S Bloom

bioRxiv· November 2024

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Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP knock-in mouse model of Alzheimer's disease.
Andrés Norambuena, Vijay Kumar Sagar, Zhuoying Wang, Prakash Raut, Ziang Feng, George S Bloom

Alzheimers Dement· October 2024

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Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers.
Xuehan Sun, Guillermo Eastman, Yu Shi, Subhi Saibaba, Ana K Oliveira, George S Bloom

Alzheimers Dement· March 2024

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Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP knock-in mouse model of Alzheimer's disease.
Andrés Norambuena, Vijay Kumar Sagar, Zhuoying Wang, Prakash Raut, Ziang Feng, George S Bloom

bioRxiv· February 2024

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A half-century of tau.
George S Bloom, Peter W Baas

Cytoskeleton (Hoboken)· January 2024

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Dysregulation of mTOR by tau in Alzheimer's disease.
George S Bloom, Andrés Norambuena

Cytoskeleton (Hoboken)· January 2024

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Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations.
Elizabeth R Sharlow, Danielle C Llaneza, Bhanu P Tewari, Garnett A Mingledorff, Anna J Mendelson, George S Bloom

FEBS J· October 2023

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High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons.
Elizabeth R Sharlow, Danielle C Llaneza, William E Grever, Garnett A Mingledorff, Anna J Mendelson, George S Bloom

SLAS Discov· September 2023

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Localization, induction, and cellular effects of tau phosphorylated at threonine 217.
Binita Rajbanshi, Anuj Guruacharya, James W Mandell, George S Bloom

Alzheimers Dement· July 2023

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Inceptor as a regulator of brain insulin sensitivity.
Lisa A Post, Joshua A Kulas, Joshua L Milstein, Sarah V L Sebastian, Seyyedmohsen Hosseini-Barkooie, George S Bloom

Sci Rep· July 2023

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Extracellular Tau Oligomers Damage the Axon Initial Segment.
Merci N Best, Yunu Lim, Nina N Ferenc, Nayoung Kim, Lia Min, George S Bloom

J Alzheimers Dis· June 2023

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Structural and functional damage to neuronal nuclei caused by extracellular tau oligomers.
Xuehan Sun, Guillermo Eastman, Yu Shi, Subhi Saibaba, Ana K Oliveira, George S Bloom

bioRxiv· May 2023

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SOD1 mediates lysosome-to-mitochondria communication and its dysregulation by amyloid-β oligomers.
Andrés Norambuena, Xuehan Sun, Horst Wallrabe, Ruofan Cao, Naidi Sun, George S Bloom

Neurobiol Dis· July 2022

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Selective Detection of Misfolded Tau From Postmortem Alzheimer's Disease Brains.
Ling Wu, Zerui Wang, Shradha Lad, Nailya Gilyazova, Darren T Dougharty, George S Bloom

Front Aging Neurosci· July 2022

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Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer's Disease Model Mice.
Guillermo Eastman, Elizabeth R Sharlow, John S Lazo, George S Bloom, José R Sotelo-Silveira

J Alzheimers Dis· April 2022

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A Novel Inhibitor Targeting NLRP3 Inflammasome Reduces Neuropathology and Improves Cognitive Function in Alzheimer's Disease Transgenic Mice.
Ram Kuwar, Andrew Rolfe, Long Di, Hallie Blevins, Yiming Xu, George S Bloom

J Alzheimers Dis· November 2021

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The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons.
Elizabeth R Sharlow, Mehmet Murat Koseoglu, George S Bloom, John S Lazo

Assay Drug Dev Technol· December 2020

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Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-β Oligomers.
Lauren K Rudenko, Horst Wallrabe, Ammasi Periasamy, Karsten H Siller, Zdenek Svindrych, George S Bloom

J Alzheimers Dis· November 2020

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A three-dimensional dementia model reveals spontaneous cell cycle re-entry and a senescence-associated secretory phenotype.
Veronica Porterfield, Shahzad S Khan, Erin P Foff, Mehmet Murat Koseoglu, Isabella K Blanco, George S Bloom

Neurobiol Aging· June 2020

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Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer's Disease and Brain Insulin Resistance, and Its Relation to Cancer.
Mehmet Murat Koseoglu, Andrés Norambuena, Elizabeth R Sharlow, John S Lazo, George S Bloom

J Alzheimers Dis· March 2020

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A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers.
Andrés Norambuena, Horst Wallrabe, Rui Cao, Dora Bigler Wang, Antonia Silva, George S Bloom

EMBO J· November 2018

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Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.
Shahzad S Khan, Michael LaCroix, Gabriel Boyle, Mathew A Sherman, Jennifer L Brown, George S Bloom

Acta Neuropathol· October 2018

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N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease.
Erin J Kodis, Sophie Choi, Eric Swanson, Gonzalo Ferreira, George S Bloom

Alzheimers Dement· October 2018

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