Publications by authors named "George D Demetri"

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Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity.
Erica M Pimenta, Amanda E Garza, Sabrina Y Camp, Jihye Park, Samantha E Hoffman, George D Demetri

bioRxiv· January 2025

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Improving Collection and Analysis of Overall Survival Data.
Lisa R Rodriguez, Nicole J Gormley, Ruixiao Lu, Anup K Amatya, George D Demetri

Clin Cancer Res· September 2024

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Safety and Efficacy of the Combination Lurbinectedin plus Doxorubicin from a Phase 1b Trial in Patients with Advanced/Metastatic Soft-Tissue Sarcoma.
Gregory M Cote, Candace L Haddox, Edwin Choy, Priscilla A Merriam, Emanuele Mazzola, George D Demetri

Clin Cancer Res· July 2024

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Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial.
Sandra P D'Angelo, Dejka M Araujo, Albiruni R Abdul Razak, Mark Agulnik, Steven Attia, George D Demetri

Lancet· April 2024

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Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas.
Shivaani Kummar, Lin Shen, David S Hong, Ray McDermott, Vicki L Keedy, George D Demetri

Cancer· December 2023

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Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor.
Michael C Heinrich, Christopher L Corless, George D Demetri, Charles D Blanke, Margaret von Mehren

J Clin Oncol· November 2023

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Impact of supraphysiologic MDM2 expression on chromatin networks and therapeutic responses in sarcoma.
Samantha M Bevill, Salvador Casaní-Galdón, Chadi A El Farran, Eli G Cytrynbaum, Kevin A Macias, George D Demetri

Cell Genom· July 2023

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Derivation and validation of a risk classification tree for patients with synovial sarcoma.
Dylan V Neel, Clement Ma, Natalie B Collins, Jason L Hornick, George D Demetri

Cancer Med· January 2023

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Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments.
Silvia Stacchiotti, Anna Maria Frezza, George D Demetri, Jean-Yves Blay, Jyoti Bajpai

Cancer Treat Rev· November 2022

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Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST.
Inga-Marie Schaefer, Matthew L Hemming, Meijun Z Lundberg, Matthew P Serrata, Isabel Goldaracena, George D Demetri

Br J Cancer· November 2022

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Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma.
Alexandra Gyurdieva, Stefan Zajic, Ya-Fang Chang, E Andres Houseman, Shan Zhong, George D Demetri

Nat Commun· September 2022

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Real-world survival outcomes in patients with locally advanced or metastatic NTRK fusion-positive solid tumors receiving standard-of-care therapies other than targeted TRK inhibitors.
Derrek P Hibar, George D Demetri, Solange Peters, Jessica Davies, Olivier Humblet

PLoS One· August 2022

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Preclinical Modeling of Leiomyosarcoma Identifies Susceptibility to Transcriptional CDK Inhibitors through Antagonism of E2F-Driven Oncogenic Gene Expression.
Matthew L Hemming, Patrick Bhola, Michael A Loycano, Justin A Anderson, Madeleine L Taddei, George D Demetri

Clin Cancer Res· June 2022

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Correction: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients with NTRK Fusion-Positive Solid Tumors.
George D Demetri, Filippo De Braud, Alexander Drilon, Salvatore Siena, Manish R Patel

Clin Cancer Res· May 2022

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Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With NTRK Fusion-Positive Solid Tumors.
George D Demetri, Filippo De Braud, Alexander Drilon, Salvatore Siena, Manish R Patel

Clin Cancer Res· April 2022

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Real-World Evidence in Support of Oncology Product Registration: A Systematic Review of New Drug Application and Biologics License Application Approvals from 2015-2020.
Bhakti Arondekar, Mei Sheng Duh, Rachel H Bhak, Maral DerSarkissian, Lynn Huynh, George D Demetri

Clin Cancer Res· January 2022

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E3 ubiquitin ligase Atrogin-1 mediates adaptive resistance to KIT-targeted inhibition in gastrointestinal stromal tumor.
Alfonso García-Valverde, Jordi Rosell, Sergi Sayols, David Gómez-Peregrina, Daniel F Pilco-Janeta, George D Demetri

Oncogene· December 2021

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Real-World Evidence and Advanced Soft Tissue Sarcoma: An Unbreakable Bond (ESMO Sarcoma and GIST Symposium 2020 Industry Satellite Symposium, Milan, February 4, 2020).
George D Demetri

Oncology· September 2021

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Ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities.
Silvia Stacchiotti, Anna Maria Frezza, Jean-Yves Blay, Elizabeth H Baldini, Sylvie Bonvalot, George D Demetri

Cancer· August 2021

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Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies.
Sebastian Bauer, George D Demetri, Ensar Halilovic, Reinhard Dummer, Christophe Meille

Br J Cancer· August 2021

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First-in-Human Phase I Study of ABBV-085, an Antibody-Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors.
George D Demetri, Jason J Luke, Antoine Hollebecque, John D Powderly, Alexander I Spira

Clin Cancer Res· July 2021

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Effect of Regorafenib in Delaying Definitive Deterioration in Health-Related Quality of Life in Patients with Advanced Cancer of Three Different Tumor Types.
Ralf-Dieter Hofheinz, Jordi Bruix, George D Demetri, Axel Grothey, Marisca Marian

Cancer Manag Res· July 2021

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Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate.
Kenji Iida, Amr H Abdelhamid Ahmed, Akiko Kawano Nagatsuma, Tomoko Shibutani, Satoru Yasuda, George D Demetri

Cancer Discov· June 2021

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Cardiac safety of trabectedin monotherapy or in combination with pegylated liposomal doxorubicin in patients with sarcomas and ovarian cancer.
Robin L Jones, Thomas J Herzog, Shreyaskumar R Patel, Margaret von Mehren, Scott M Schuetze, George D Demetri

Cancer Med· June 2021

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Contributions of Real-World Evidence and Real-World Data to Decision-Making in the Management of Soft Tissue Sarcomas.
George D Demetri, Silvia Stacchiotti

Oncology· April 2021

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