Publications by authors named "George D Mcilroy"

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Hydroxysteroid 17β-dehydrogenase 13 (Hsd17b13) knockdown attenuates liver steatosis in high-fat diet obese mice.
Shehroz Mahmood, Nicola Morrice, Dawn Thompson, Sara Milanizadeh, Sophie Wilson, George D Mcilroy

Exp Physiol· August 2025

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Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee.
Jessica J McClure, George D McIlroy, Rebecca A Symons, Susan M Clark, Iain Cunningham

Osteoarthritis Cartilage· December 2024

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Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy.
Mansi Tiwari, Ahlima Roumane, Nadine Sommer, Weiping Han, Mirela Delibegović, George D Mcilroy

Gene Ther· September 2024

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Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip), Pisa, Italy, 28-29 September 2023.
Giovanni Ceccarini, Baris Akinci, David Araujo-Vilar, Marianna Beghini, Rebecca J Brown, George D McIlroy

Ann Endocrinol (Paris)· July 2024

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GLP-1 receptor agonist improves metabolic disease in a pre-clinical model of lipodystrophy.
Ahlima Roumane, George D Mcilroy, Nadine Sommer, Weiping Han, Lora K Heisler

Front Endocrinol (Lausanne)· May 2024

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From scarcity to solutions: Therapeutic strategies to restore adipose tissue functionality in rare disorders of lipodystrophy.
Mansi Tiwari, George D Mcilroy

Diabet Med· December 2023

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Gene therapy restores adipose tissue and metabolic health in a pre-clinical mouse model of lipodystrophy.
Nadine Sommer, Ahlima Roumane, Weiping Han, Mirela Delibegović, Justin J Rochford, George D Mcilroy

Mol Ther Methods Clin Dev· December 2022

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High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice - partial prevention by Fenretinide.
Kaja Plucińska, Nimesh Mody, Ruta Dekeryte, Kirsty Shearer, George D Mcilroy

Nutr Neurosci· April 2022

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Deficiency Does Not Directly Impair the Innate Immune Response in a Murine Model of Generalized Lipodystrophy.
Ahlima Roumane, George D Mcilroy, Arda Balci, Weiping Han, Mirela Delibegović

J Clin Med· January 2021

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Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.
M F Michelle Sim, Elisa Persiani, Md Mesbah Uddin Talukder, George D Mcilroy, Ahlima Roumane

Sci Rep· February 2020

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Ablation of /seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy.
George D Mcilroy, Sharon E Mitchell, Weiping Han, Mirela Delibegović, Justin J Rochford

Dis Model Mech· January 2020

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Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.
George D Mcilroy, Sharon E Mitchell, Weiping Han, Mirela Delibegović, Justin J Rochford

Sci Rep· December 2018

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Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease.
George D Mcilroy, Karla Suchacki, Anke J Roelofs, Wulin Yang, Yanyun Fu

Mol Metab· April 2018

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Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice.
Nicola Morrice, George D Mcilroy, Seshu R Tammireddy, Jennifer Reekie, Kirsty D Shearer

Sci Rep· March 2017

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Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue.
George D Mcilroy, Seshu R Tammireddy, Benjamin H Maskrey, Louise Grant, Mary K Doherty

Biochem Pharmacol· January 2016

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Fenretinide prevents obesity in aged female mice in association with increased retinoid and estrogen signaling.
Kirsty D Shearer, Nicola Morrice, Claire Henderson, Jenny Reekie, George D Mcilroy

Obesity (Silver Spring)· August 2015

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The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes.
Nimesh Mody, George D Mcilroy

Biochem Pharmacol· October 2014

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Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus.
George D Mcilroy, Mirela Delibegovic, Carl Owen, Patrick N Stoney, Kirsty D Shearer

Diabetes· March 2013

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Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
Carl Owen, Alicja Czopek, Abdelali Agouni, Louise Grant, Robert Judson, George D Mcilroy

PLoS One· July 2012

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