Publications by authors named "George Derbin"

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Role of Self-Association and Supersaturation in Oral Absorption of a Poorly Soluble Weakly Basic Drug.
Ajit S Narang, Sherif Badawy, Qingmei Ye, Dhaval Patel, Maria Vincent, George Derbin

Pharm Res· August 2015

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Food increased the bioavailability of BMS-690514, an orally active EGFR/HER2/VEGF receptor kinase inhibitor, in healthy subjects.
Blisse Vakkalagadda, Jong-Soon Park, Christoph M Ahlers, Stephanie Dorizio, Teresa Has, George M Derbin

J Clin Pharmacol· September 2012

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Acid-catalyzed hydrolysis of BMS-582664: degradation product identification and mechanism elucidation.
Fang Zhao, George Derbin, Scott Miller, Sherif Badawy, Munir Hussain

J Pharm Sci· September 2012

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Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds.
R Marcus Fancher, Hongjian Zhang, Bogdan Sleczka, George Derbin, Richard Rockar

J Pharm Sci· July 2011

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Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.
Réjean Ruel, Carl Thibeault, Alexandre L'Heureux, Alain Martel, Zhen-Wei Cai, George Derbin

Bioorg Med Chem Lett· May 2008

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Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor (BMS-540215).
Zhen-wei Cai, Yongzheng Zhang, Robert M Borzilleri, Ligang Qian, Stephanie Barbosa, George Derbin

J Med Chem· March 2008

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Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2.
Robert M Borzilleri, Rajeev S Bhide, Joel C Barrish, Celia J D'Arienzo, George M Derbin

J Med Chem· June 2006

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Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor.
Rajeev S Bhide, Zhen-Wei Cai, Yong-Zheng Zhang, Ligang Qian, Donna Wei, George Derbin

J Med Chem· April 2006

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