Publications by authors named "George Dickson"

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Systemic Intravenous Administration of Antisense Therapeutics for Combinatorial Dystrophin and Myostatin Exon Splice Modulation.
Ngoc Lu-Nguyen, George Dickson, Alberto Malerba

Methods Mol Biol· July 2025

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Improving Molecular and Histopathology in Diaphragm Muscle of the Double Transgenic ACTA1-MCM/FLExDUX4 Mouse Model of FSHD with Systemic Antisense Therapy.
Ngoc Lu-Nguyen, Alberto Malerba, Marina Antoni Pineda, George Dickson, Linda Popplewell

Hum Gene Ther· September 2022

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Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMD rat model.
Audrey Bourdon, Virginie François, Liwen Zhang, Aude Lafoux, Bodvael Fraysse, George Dickson

Gene Ther· September 2022

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Long-Term Systemic Treatment of a Mouse Model Displaying Chronic FSHD-like Pathology with Antisense Therapeutics That Inhibit Expression.
Ngoc Lu-Nguyen, George Dickson, Alberto Malerba, Linda Popplewell

Biomedicines· July 2022

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Targeted exon skipping of exon 17 as a therapeutic for neurofibromatosis type I.
André Leier, Marc Moore, Hui Liu, Michael Daniel, Alexis M Hyde, George Dickson

Mol Ther Nucleic Acids· June 2022

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Gene Therapy for Duchenne Muscular Dystrophy.
Nertiyan Elangkovan, George Dickson

J Neuromuscul Dis· January 2022

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Knockdown of Muscle-Specific Ribosomal Protein L3-Like Enhances Muscle Function in Healthy and Dystrophic Mice.
Betty R Kao, Alberto Malerba, Ngoc B Lu-Nguyen, Pradeep Harish, John J McCarthy, George Dickson

Nucleic Acid Ther· December 2021

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A new strategy to increase RNA editing at the Q/R site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2.
Helena Chaytow, Ilda Sethw Hassan, Sara Akbar, Linda Popplewell, George Dickson

J Neurosci Methods· December 2021

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Dose-Dependent Microdystrophin Expression Enhancement in Cardiac Muscle by a Cardiac-Specific Regulatory Element.
Alberto Malerba, Chiara Sidoli, Ngoc Lu-Nguyen, Shan Herath, Anita Le Heron, George Dickson

Hum Gene Ther· October 2021

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Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model.
Ngoc Lu-Nguyen, Alberto Malerba, Shan Herath, George Dickson, Linda Popplewell

Hum Mol Genet· July 2021

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BB-301: a silence and replace AAV-based vector for the treatment of oculopharyngeal muscular dystrophy.
Vanessa Strings-Ufombah, Alberto Malerba, Shih-Chu Kao, Sonal Harbaran, Fanny Roth, George Dickson

Mol Ther Nucleic Acids· June 2021

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RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways.
Victoria Gudiño, Sebastian Öther-Gee Pohl, Caroline V Billard, Patrizia Cammareri, Alfonso Bolado, George Dickson

Nat Commun· April 2021

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Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy.
Haiyan Zhou, Jinhong Meng, Alberto Malerba, Francesco Catapano, Palittiya Sintusek, George Dickson

J Cachexia Sarcopenia Muscle· June 2020

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Mutation-Directed Therapeutics for Neurofibromatosis Type I.
Andre Leier, David M Bedwell, Ann T Chen, George Dickson, Kim M Keeling

Mol Ther Nucleic Acids· June 2020

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Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy.
Diane E Frank, Frederick J Schnell, Cody Akana, Saleh H El-Husayni, Cody A Desjardins, George Dickson

Neurology· May 2020

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G-quadruplex ligands mediate downregulation of DUX4 expression.
Lukasz Ciszewski, Ngoc Lu-Nguyen, Alex Slater, Andrew Brennan, Huw E L Williams, George Dickson

Nucleic Acids Res· May 2020

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Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease.
Pradeep Harish, Leysa Forrest, Shanti Herath, George Dickson, Alberto Malerba

Front Physiol· March 2020

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Vaccination of Macaques with DNA Followed by Adenoviral Vectors Encoding Simian Immunodeficiency Virus (SIV) Gag Alone Delays Infection by Repeated Mucosal Challenge with SIV.
Neil Almond, Neil Berry, Richard Stebbings, Mark Preston, Claire Ham, George Dickson

J Virol· November 2019

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Inhibition of myostatin improves muscle atrophy in oculopharyngeal muscular dystrophy (OPMD).
Pradeep Harish, Alberto Malerba, Ngoc Lu-Nguyen, Leysa Forrest, Ornella Cappellari, George Dickson

J Cachexia Sarcopenia Muscle· October 2019

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Established PABPN1 intranuclear inclusions in OPMD muscle can be efficiently reversed by AAV-mediated knockdown and replacement of mutant expanded PABPN1.
Alberto Malerba, Pierre Klein, Ngoc Lu-Nguyen, Ornella Cappellari, Vanessa Strings-Ufombah, George Dickson

Hum Mol Genet· October 2019

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Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice.
Ngoc Lu-Nguyen, Arnaud Ferry, Frederick J Schnell, Gunnar J Hanson, Linda Popplewell, George Dickson

Hum Mol Genet· September 2019

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Pharmacological modulation of the ER stress response ameliorates oculopharyngeal muscular dystrophy.
Alberto Malerba, Fanny Roth, Pradeep Harish, Jamila Dhiab, Ngoc Lu-Nguyen, George Dickson

Hum Mol Genet· May 2019

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Systemic Intravenous Administration of Antisense Therapeutics for Combinatorial Dystrophin and Myostatin Exon Splice Modulation.
Ngoc Lu-Nguyen, George Dickson, Alberto Malerba

Methods Mol Biol· April 2019

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A multicenter comparison of quantification methods for antisense oligonucleotide-induced DMD exon 51 skipping in Duchenne muscular dystrophy cell cultures.
Monika Hiller, Maria Sofia Falzarano, Iker Garcia-Jimenez, Valentina Sardone, Ruurd C Verheul, George Dickson

PLoS One· March 2019

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Functional Rescue of Dystrophin Deficiency in Mice Caused by Frameshift Mutations Using Campylobacter jejuni Cas9.
Taeyoung Koo, Ngoc B Lu-Nguyen, Alberto Malerba, Eunji Kim, Daesik Kim, George Dickson

Mol Ther· June 2018

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