Publications by authors named "Gerald Horan"

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Phase 2, Double-Blind, Placebo-controlled Trial of a c-Jun N-Terminal Kinase Inhibitor in Idiopathic Pulmonary Fibrosis.
Waldo L L D Mattos, Nasreen Khalil, Lisa G Spencer, Francesco Bonella, Rodney J Folz, Gerald S Horan

Am J Respir Crit Care Med· August 2024

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Safety, Pharmacokinetics, and Antifibrotic Activity of CC-90001 (BMS-986360), a c-Jun N-Terminal Kinase Inhibitor, in Pulmonary Fibrosis.
Gerald Horan, Ying Ye, Mary Adams, Anastasia Parton, Dorota Cedzik

Clin Pharmacol Drug Dev· August 2023

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Safety, Pharmacokinetics, and Pharmacodynamics of CC-90001 (BMS-986360), a c-Jun N-terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants.
Ying Ye, Allison Gaudy, Michael Thomas, Josephine Reyes, Barbara Burkhardt, Gerald Horan

Clin Pharmacol Drug Dev· December 2022

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CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production.
Rajula Gaur, Kofi A Mensah, Jason Stricker, Mary Adams, Anastasia Parton, Gerald Horan

Arthritis Res Ther· August 2022

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CC-90001, a c-Jun N-terminal kinase (JNK) inhibitor, in patients with pulmonary fibrosis: design of a phase 2, randomised, placebo-controlled trial.
Zoran Popmihajlov, Donna J Sutherland, Gerald S Horan, Atalanta Ghosh, David A Lynch

BMJ Open Respir Res· January 2022

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Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice.
Peter H Schafer, Mary Adams, Gerald Horan, Francesca Truzzi, Alessandra Marconi

Drugs R D· December 2019

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Pomalidomide in Patients with Interstitial Lung Disease due to Systemic Sclerosis: A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study.
Vivien M Hsu, Christopher P Denton, Robyn T Domsic, Daniel E Furst, Maureen Rischmueller, Gerald Horan

J Rheumatol· March 2018

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JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.
Jos L J van der Velden, Ying Ye, James D Nolin, Sidra M Hoffman, David G Chapman, Gerald Horan

Clin Transl Med· December 2016

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Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex.
Peter H Schafer, Francesca Truzzi, Anastasia Parton, Lei Wu, Jolanta Kosek, Gerald Horan

Cell Signal· July 2016

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Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice.
Poshala Aluwihare, Zhenyu Mu, Zhicheng Zhao, Dawen Yu, Paul H Weinreb, Gerald S Horan

J Cell Sci· January 2009

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Role of integrin alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa.
Yuanlin Song, Jean Francois Pittet, Xiaozhu Huang, Hong He, Susan V Lynch, Gerald S Horan

Infect Immun· June 2008

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Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
Michael T Ganter, Jérémie Roux, Byron Miyazawa, Marybeth Howard, James A Frank, Gerald S Horan

Circ Res· April 2008

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Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.
Khalid Puthawala, Nicos Hadjiangelis, Steven C Jacoby, Emmanuel Bayongan, Zhicheng Zhao, Gerald S Horan

Am J Respir Crit Care Med· January 2008

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Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
Gerald S Horan, Susan Wood, Victor Ona, Dan Jun Li, Matvey E Lukashev

Am J Respir Crit Care Med· January 2008

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Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism.
Louise A Koopman Van Aarsen, Diane R Leone, Steffan Ho, Brian M Dolinski, Patricia E McCoon, Gerald S Horan

Cancer Res· January 2008

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Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.
Kyungmin Hahm, Matvey E Lukashev, Yi Luo, William J Yang, Brian M Dolinski, Gerald S Horan

Am J Pathol· January 2007

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Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model.
R Blake Pepinsky, Renee I Shapiro, Shaoshan Wang, Abhijit Chakraborty, Alan Gill, Gerald S B Horan

J Pharm Sci· February 2002

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