Publications by authors named "Gerhard Fritz"

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Epigenetic targeting of DNA damage response (DDR)-related mechanisms to overcome acquired cisplatin resistance of tumor cells.
Marlena Sekeres, Daniel Lengle, Lena Abbey, Matthias Ulrich Kassack, Fabian Fischer, Gerhard Fritz

Biochim Biophys Acta Mol Cell Res· October 2025

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Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse.
Julia Mann, Kathrin Niedermayer, Johannes Krautstrunk, Lena Abbey, Lisa Wiesmüller, Gerhard Fritz

Int J Cancer· January 2025

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Evaluation of Genotoxic Effects of N-Methyl-N-Nitroso-Urea and Etoposide on the Differentiation Potential of MSCs from Umbilical Cord Blood and Bone Marrow.
Meryem Ouzin, Sebastian Wesselborg, Gerhard Fritz, Gesine Kogler

Cells· December 2024

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Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs).
Laura Schmitt, Julia Hoppe, Pablo Cea-Medina, Peter-Martin Bruch, Karina S Krings, Gerhard Fritz

Cell Death Discov· June 2024

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Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42.
Pelin Kücük, Lena Abbey, Joachim Schmitt, Christian Henninger, Gerhard Fritz

Pharmacol Res· May 2024

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Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2.
Laura Schmitt, Ilka Lechtenberg, Daniel Drießen, Hector Flores-Romero, Margaretha A Skowron, Gerhard Fritz

Cell Death Discov· March 2024

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Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans.
Fabian Wynen, Johannes Krautstrunk, Lisa Marie Müller, Viktoria Graf, Vanessa Brinkmann, Gerhard Fritz

Biochim Biophys Acta Mol Cell Res· January 2024

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Nuclear RAC1 is a modulator of the doxorubicin-induced DNA damage response.
Rebekka Kitzinger, Gerhard Fritz, Christian Henninger

Biochim Biophys Acta Mol Cell Res· October 2022

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Prevention of anticancer therapy-induced neurotoxicity: Putting DNA damage in perspective.
Vanessa Brinkmann, Gerhard Fritz

Neurotoxicology· July 2022

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Targeting Mechanisms of the DNA Damage Response (DDR) and DNA Repair by Natural Compounds to Improve cAT-Triggered Tumor Cell Death.
Jana Aengenvoort, Marlena Sekeres, Peter Proksch, Gerhard Fritz

Molecules· June 2022

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Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression.
Daniela Hanisch, Andrea Krumm, Tamara Diehl, Carla M Stork, Mario Dejung, Gerhard Fritz

Cell Death Dis· April 2022

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Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission.
Anna Wellenberg, Vanessa Brinkmann, Julia Bornhorst, Natascia Ventura, Sebastian Honnen, Gerhard Fritz

Pharmacol Res· December 2021

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Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways.
Leonie Schürmann, Lena Schumacher, Katharina Roquette, Anamaria Brozovic, Gerhard Fritz

Cancer Lett· November 2021

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Effects of Manganese on Genomic Integrity in the Multicellular Model Organism .
Merle M Nicolai, Ann-Kathrin Weishaupt, Jessica Baesler, Vanessa Brinkmann, Anna Wellenberg, Gerhard Fritz

Int J Mol Sci· October 2021

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Use of C. elegans as a 3R-compliant in vivo model for the chemoprevention of cisplatin-induced neurotoxicity.
Anna Wellenberg, Lea Weides, Jennifer Kurzke, Till Hennecke, Julia Bornhorst, Gerhard Fritz

Exp Neurol· July 2021

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Distinct influence of the anthracycline derivative doxorubicin on the differentiation efficacy of mESC-derived endothelial progenitor cells.
Sarah K Jahn, Tatiana Hennicke, Matthias U Kassack, Leonie Drews, Andreas S Reichert, Gerhard Fritz

Biochim Biophys Acta Mol Cell Res· July 2020

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In Vitro Assessment of the Genotoxic Hazard of Novel Hydroxamic Acid- and Benzamide-Type Histone Deacetylase Inhibitors (HDACi).
Annabelle Friedrich, Ann-Sophie Assmann, Lena Schumacher, Jana V Stuijvenberg, Matthias U Kassack, Gerhard Fritz

Int J Mol Sci· July 2020

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Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer.
Verena Ziegler, Marco Deußen, Lena Schumacher, Wynand P Roos, Gerhard Fritz

Biochim Biophys Acta Mol Cell Res· June 2020

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Targeting the DNA damage response (DDR) by natural compounds.
Jana van Stuijvenberg, Peter Proksch, Gerhard Fritz

Bioorg Med Chem· February 2020

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Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in .
Andreas Jahn, Bo Scherer, Gerhard Fritz, Sebastian Honnen

Aging Dis· February 2020

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Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y receptor antagonist.
Nicole Brockmann, Parichat Sureechatchaiyan, David Müller, Tatiana Hennicke, Ralf Hausmann, Gerhard Fritz

Purinergic Signal· September 2019

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Human primary endothelial cells are impaired in nucleotide excision repair and sensitive to benzo[a]pyrene compared with smooth muscle cells and pericytes.
Joana M Kress, Lorella Di Dio, Larissa Heck, Alessandra Pulliero, Alberto Izzotti, Gerhard Fritz

Sci Rep· September 2019

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Distinct contribution of Rac1 expression in cardiomyocytes to anthracycline-induced cardiac injury.
Christian Henninger, Stephanie Pohlmann, Verena Ziegler, Jan Ohlig, Joachim Schmitt, Gerhard Fritz

Biochem Pharmacol· June 2019

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Werner syndrome (WRN) DNA helicase and base excision repair (BER) factors maintain endothelial homeostasis.
Kathrin Laarmann, Joana M Kress, Bernd Kaina, Gerhard Fritz

DNA Repair (Amst)· January 2019

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Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia.
Stephanie Pohlmann, Stefanie Scheu, Verena Ziegler, Nicole Schupp, Christian Henninger, Gerhard Fritz

Biochim Biophys Acta Mol Cell Res· September 2018

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