Publications by authors named "Gernot Polier"

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A novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1.
Masashi Numata, Noriyasu Haginoya, Machiko Shiroishi, Tsuyoshi Hirata, Aiko Sato-Otsubo, Gernot Polier

Cancer Cell Int· February 2023

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Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.
Gernot Polier, Marco Giaisi, Rebecca Köhler, Wolfgang W Müller, Christoph Lutz

Int J Cancer· February 2015

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The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.
Gernot Polier, Jennifer Neumann, Frédéric Thuaud, Nigel Ribeiro, Christoph Gelhaus

Chem Biol· September 2012

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Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression.
Jie Ding, Gernot Polier, Rebecca Köhler, Marco Giaisi, Peter H Krammer

J Biol Chem· January 2012

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High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.
Michael K Kiessling, Patrick A Oberholzer, Chandrani Mondal, Maria B Karpova, Marie C Zipser, Gernot Polier

Blood· February 2011

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