Publications by authors named "Gesi Wen"

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Targeting the hydrophobic region of pyroglutamate-modified amyloid-β by tyrocidine A prevents its nucleation-aggregation process and its "catalytic effect" on the Aβs aggregation.
Wenjing Qin, Daoyuan Chen, Youqiao Wang, Ziyi Liu, Binhua Zhou, Gesi Wen

J Biochem Mol Toxicol· August 2024

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Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy.
Xin Yue, Tingyu Liu, Xuecen Wang, Weijian Wu, Gesi Wen, Wenyan Qiu

Acta Pharm Sin B· August 2023

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Stabilization of DEPTOR sensitizes hypopharyngeal cancer to radiotherapy via targeting degradation.
Xuecen Wang, Zhirui Cao, Xin Yue, Tingyu Liu, Gesi Wen

Mol Ther Oncolytics· September 2022

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Dissociation of haemolytic and oligomer-preventing activities of gramicidin S derivatives targeting the amyloid-β N-terminus.
Daoyuan Chen, Wenjing Qin, Gesi Wen, Bihua Shi, Ziyi Liu

Chem Commun (Camb)· December 2017

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Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.
Xin Yue, Yinglin Zuo, Hongpeng Ke, Jiaming Luo, Lanlan Lou, Wenjing Qin, Gesi Wen

Biochem Pharmacol· August 2017

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Stabilizing amyloid-β peptide by the N-terminus capture is capable of preventing and eliminating amyloid-β oligomers.
Gesi Wen, Daoyuan Chen, Wenjing Qin, Binhua Zhou, Youqiao Wang

Chem Commun (Camb)· July 2017

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Stabilizing the monomeric amyloid-β peptide by tyrocidine A prevents and reverses amyloidogenesis without the accumulation of oligomers.
Gesi Wen, Wenjing Qin, Daoyuan Chen, Youqiao Wang, Xin Yue

Chem Commun (Camb)· March 2017

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MC37, a new mono-carbonyl curcumin analog, induces G2/M cell cycle arrest and mitochondria-mediated apoptosis in human colorectal cancer cells.
Baoxia Liang, Ziyi Liu, Yingnan Cao, Cuige Zhu, Yinglin Zuo, Gesi Wen

Eur J Pharmacol· February 2017

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Mitochondria-Targeted Approach: Remarkably Enhanced Cellular Bioactivities of TPP2a as Selective Inhibitor and Probe toward TrxR.
Baoxia Liang, Weiyan Shao, Cuige Zhu, Gesi Wen, Xin Yue

ACS Chem Biol· February 2016

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Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe.
Cuige Zhu, Yinglin Zuo, Baoxia Liang, Hong Yue, Xin Yue, Gesi Wen

Chem Commun (Camb)· September 2015

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Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.
Cuige Zhu, Yinglin Zuo, Ruimin Wang, Baoxia Liang, Xin Yue, Gesi Wen

J Med Chem· August 2014

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A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off-on fluorescent probe for covalent labelling of thioredoxin reductase.
Lei Huang, Yu Chen, Baoxia Liang, Bengang Xing, Gesi Wen

Chem Commun (Camb)· July 2014

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Synthesis and identification of new flavonoids targeting liver X receptor β involved pathway as potential facilitators of Aβ clearance with reduced lipid accumulation.
Yun Hu, Yaqi Yang, Yanjun Yu, Gesi Wen, Nana Shang

J Med Chem· August 2013

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Synthesis, cytotoxicity of new 4-arylidene curcumin analogues and their multi-functions in inhibition of both NF-κB and Akt signalling.
Yinglin Zuo, Jianing Huang, Binhua Zhou, Shuni Wang, Weiyan Shao, Gesi Wen

Eur J Med Chem· September 2012

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