Publications by authors named "Gethin Thomas"

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In vitro comparison of CD20xCD3 bispecific antibodies against diffuse large B-cell lymphoma (DLBCL) cell lines with different levels of expression of CD20.
Joshua S Bray, Gethin R Thomas, Victoria M Smith, Adam Wright, Sandrine Jayne

Br J Haematol· May 2025

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A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageing.
Vinesh Dhokia, Amal Albati, Hannah Smith, Gethin Thomas, Salvador Macip

Biochem Soc Trans· August 2024

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MiNDAUS partnership: a roadmap for the cure and management of motor Neurone disease.
Steve Vucic, Naomi Wray, Anjali Henders, Robert D Henderson, Paul Talman, Gethin Thomas, Geoff Thomas

Amyotroph Lateral Scler Frontotemporal Degener· August 2022

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Interleukin-1 Is Overexpressed in Injured Muscles Following Spinal Cord Injury and Promotes Neurogenic Heterotopic Ossification.
Hsu-Wen Tseng, Irina Kulina, Dorothée Girard, Jules Gueguen, Cedryck Vaquette, Gethin Thomas

J Bone Miner Res· March 2022

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An -Ethyl--Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion.
Christopher T Esapa, Sian E Piret, M Andrew Nesbit, Gethin P Thomas, Leslie A Coulton

JBMR Plus· May 2018

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Genetic Variants in ERAP1 and ERAP2 Associated With Immune-Mediated Diseases Influence Protein Expression and the Isoform Profile.
Aimee L Hanson, Thomas Cuddihy, Katelin Haynes, Dorothy Loo, Craig J Morton, Gethin P Thomas

Arthritis Rheumatol· February 2018

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Mice with an N-Ethyl-N-Nitrosourea (ENU) Induced Tyr209Asn Mutation in Natriuretic Peptide Receptor 3 (NPR3) Provide a Model for Kyphosis Associated with Activation of the MAPK Signaling Pathway.
Christopher T Esapa, Sian E Piret, M Andrew Nesbit, Nellie Y Loh, Gethin Thomas

PLoS One· June 2017

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Early anti-inflammatory intervention ameliorates axial disease in the proteoglycan-induced spondylitis mouse model of ankylosing spondylitis.
Hsu-Wen Tseng, Tibor T Glant, Matthew A Brown, Tony J Kenna, Gethin P Thomas

BMC Musculoskelet Disord· May 2017

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Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis.
Max C Lau, Patricia Keith, Mary-Ellen Costello, Linda A Bradbury, Kelly A Hollis, Ranjeny Thomas, Gethin P Thomas

Ann Rheum Dis· January 2017

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Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.
Zewen Kelvin Tuong, Rebecca Fitzsimmons, Shu-Ching Mary Wang, Tae Gyu Oh, Patrick Lau, Gethin Thomas

EBioMedicine· September 2016

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N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.
Christopher T Esapa, Fadil M Hannan, Valerie N Babinsky, Paul Potter, Gethin P Thomas

PLoS One· March 2016

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Inflammation-driven bone formation in a mouse model of ankylosing spondylitis: sequential not parallel processes.
Hsu-Wen Tseng, Miranda E Pitt, Tibor T Glant, Allan F McRae, Tony J Kenna, Gethin P Thomas

Arthritis Res Ther· January 2016

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ERAP2 functional knockout in humans does not alter surface heavy chains or HLA-B27, inflammatory cytokines or endoplasmic reticulum stress markers.
Philip C Robinson, Eugene Lau, Patricia Keith, Max C Lau, Gethin P Thomas

Ann Rheum Dis· November 2015

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Treatment of a mouse model of ankylosing spondylitis with exogenous sclerostin has no effect on disease progression.
Katelin R Haynes, Hsu-Wen Tseng, Michaela Kneissel, Tibor T Glant, Matthew A Brown, Gethin P Thomas

BMC Musculoskelet Disord· November 2015

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Confluence-Induced Squamous Differentiation Is Not Accompanied by Changes in H3K27me3 Repressive Epigenetic Mark.
Orla M Gannon, Lilia Merida de Long, Mehlika Hazar-Rethinam, Eleni Topkas, Liliana B Endo-Munoz, Gethin P Thomas

J Invest Dermatol· October 2015

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Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing.
Michael B Clark, Tim R Mercer, Giovanni Bussotti, Tommaso Leonardi, Katelin R Haynes, Gethin P Thomas

Nat Methods· April 2015

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Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.
Patrick Lau, Zewen K Tuong, Shu-Ching Wang, Rebecca L Fitzsimmons, Joel M Goode, Gethin P Thomas

Am J Physiol Endocrinol Metab· January 2015

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Resveratrol does not benefit patients with nonalcoholic fatty liver disease.
Veronique S Chachay, Graeme A Macdonald, Jennifer H Martin, Jonathan P Whitehead, Trisha M O'Moore-Sullivan, Gethin P Thomas

Clin Gastroenterol Hepatol· December 2014

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Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.
Glen A Kennedy, Antiopi Varelias, Slavica Vuckovic, Laetitia Le Texier, Kate H Gartlan, Gethin Thomas

Lancet Oncol· December 2014

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Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration.
Katharine M Irvine, Richard Skoien, Nilesh J Bokil, Michelle Melino, Gethin P Thomas

World J Gastroenterol· December 2014

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Detailed surface morphology of the 'lobster louse' copepod, Nicothoë astaci, a haematophagous gill parasite of the European lobster, Homarus gammarus.
Charlotte E Davies, Gethin R Thomas, Thierry G G Maffeis, Emma C Wootton, Mark W Penny

J Invertebr Pathol· October 2014

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Interleukin-23 mediates the intestinal response to microbial β-1,3-glucan and the development of spondyloarthritis pathology in SKG mice.
Helen Benham, Linda M Rehaume, Sumaira Z Hasnain, Jared Velasco, Athan C Baillet, Gethin P Thomas, Ranjeny Thomas

Arthritis Rheumatol· July 2014

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The IFITM5 mutation c.-14C > T results in an elongated transcript expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta type V.
Syndia Lazarus, Aideen M McInerney-Leo, Fiona A McKenzie, Gareth Baynam, Stephanie Broley, Gethin Thomas

BMC Musculoskelet Disord· March 2014

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Expression profiling in spondyloarthropathy synovial biopsies highlights changes in expression of inflammatory genes in conjunction with tissue remodelling genes.
Gethin P Thomas, Ran Duan, Allison R Pettit, Helen Weedon, Simranpreet Kaur

BMC Musculoskelet Disord· December 2013

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Transgenic muscle-specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism, and endurance.
Michael A Pearen, Joel M Goode, Rebecca L Fitzsimmons, Natalie A Eriksson, Gethin P Thomas

Mol Endocrinol· November 2013

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