Publications by authors named "Giorgio Senaldi"

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Anti-human TLR7 antibody for therapeutic intervention in systemic lupus erythematosus.
Ryutaro Fukui, Yusuke Murakami, Atsuo Kanno, Yuji Motoi, Atsushi Manno, Giorgio Senaldi

Int Immunol· September 2025

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First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of DS-7011a, an Anti-TLR7 Antagonistic Monoclonal Antibody for the Treatment of Systemic Lupus Erythematosus.
Giorgio Senaldi, Aparna Mohan, Li Zhang, Jun Tanaka, Yong Lin

J Clin Pharmacol· August 2024

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A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers.
Hui K Gan, Sagun Parakh, F T Lee, Niall C Tebbutt, Malaka Ameratunga, Giorgio Senaldi

Invest New Drugs· August 2022

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U.S. Phase I First-in-human Study of Taletrectinib (DS-6051b/AB-106), a ROS1/TRK Inhibitor, in Patients with Advanced Solid Tumors.
Kyriakos P Papadopoulos, Erkut Borazanci, Alice T Shaw, Ryohei Katayama, Yuki Shimizu, Giorgio Senaldi

Clin Cancer Res· September 2020

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Molecular imaging of T cell co-regulator factor B7-H3 with Zr-DS-5573a.
Ingrid Julienne Georgette Burvenich, Sagun Parakh, Fook-Thean Lee, Nancy Guo, Zhanqi Liu, Giorgio Senaldi

Theranostics· September 2019

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First-in-human study of the anti-HB-EGF antibody U3-1565 in subjects with advanced solid tumors.
Kathleen N Moore, Johanna C Bendell, Patricia M LoRusso, Anthony J Olszanski, Esther Zwick-Wallasch, Giorgio Senaldi

Invest New Drugs· February 2019

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A Phase I, Single-Ascending-Dose Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DS-2969b, a Novel GyrB Inhibitor.
Justin Dennie, Alexander G Vandell, Satoshi Inoue, Roohi Gajee, Joseph Pav, Giorgio Senaldi

J Clin Pharmacol· December 2018

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Open-Label Single-Dose Study to Assess the Effect of Mild and Moderate Hepatic Impairment on the Pharmacokinetics of Mirogabalin.
Kenneth Duchin, Giorgio Senaldi, Vance Warren, Thomas Marbury, Kenneth Lasseter

Clin Drug Investig· November 2018

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Phase 1 Study To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Oral Doses of DS-2969b, a Novel GyrB Inhibitor, in Healthy Subjects.
Alexander G Vandell, Satoshi Inoue, Justin Dennie, Yasuo Nagasawa, Roohi Gajee, Giorgio Senaldi

Antimicrob Agents Chemother· May 2018

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and Evaluation of Zr-DS-8273a as a Theranostic for Anti-Death Receptor 5 Therapy.
Ingrid J G Burvenich, Fook-Thean Lee, Nancy Guo, Hui K Gan, Angela Rigopoulos, Giorgio Senaldi

Theranostics· October 2017

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A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of DS-3801b, a Motilin Receptor Agonist, in Healthy Subjects.
Justin Dennie, George Atiee, Vance Warren, Ben Tao, Kiyoshi Morimoto, Giorgio Senaldi

J Clin Pharmacol· September 2017

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First-in-human study of the antibody DR5 agonist DS-8273a in patients with advanced solid tumors.
Andres Forero, Johanna C Bendell, Prasanna Kumar, Linda Janisch, Michael Rosen, Giorgio Senaldi

Invest New Drugs· June 2017

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Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a.
Ingrid J G Burvenich, Sagun Parakh, Hui K Gan, Fook-Thean Lee, Nancy Guo, Giorgio Senaldi

J Nucl Med· June 2016

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Granulocyte colony-stimulating factor decreases tumor necrosis factor production in whole blood: role of interleukin-10 and prostaglandin E(2).
Davide Agnello, Patrizia Mascagni, Riccardo Bertini, Pia Villa, Giorgio Senaldi

Eur Cytokine Netw· July 2005

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Comparative study of gp130 cytokine effects on corticotroph AtT-20 cells--redundancy or specificity of neuroimmunoendocrine modulators?
Christoph J Auernhammer, Florian B Kopp, George Vlotides, Franziska Dorn, Nicola B Isele, Giorgio Senaldi

Neuroimmunomodulation· October 2004

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Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein.
Britta Siegmund, Joseph A Sennello, Hans A Lehr, Giorgio Senaldi, Charles A Dinarello

Eur J Immunol· September 2004

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TNFalpha in experimental diseases of the CNS.
Roberto Furlan, Pia Villa, Giorgio Senaldi, Gianvito Martino

Methods Mol Med· April 2004

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Pretreatment with granulocyte-colony stimulating factor decreases lipopolysaccharide-induced interferon-gamma production in mice in association with the production of interleukin-18.
Christine L Shaklee, Jane Guo, Raffaella Faggioni, Giamila Fantuzzi, Giorgio Senaldi

Cytokine· February 2004

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Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.
Renate Burger, Frank Bakker, Andreas Guenther, Wolfgang Baum, Dirk Schmidt-Arras, Giorgio Senaldi

Br J Haematol· December 2003

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Regulatory effects of osteoprotegerin on cellular and humoral immune responses.
Marina Stolina, Jane Guo, Raffaella Faggioni, Heather Brown, Giorgio Senaldi

Clin Immunol· December 2003

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Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3.
Christoph J Auernhammer, Nicola B Isele, Florian B Kopp, Gerald Spoettl, Neziha Cengic, Giorgio Senaldi

Endocrinology· April 2003

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Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein.
Nirmal K Banda, Andrea Vondracek, Damian Kraus, Charles A Dinarello, Soo-Hyun Kim, Giorgio Senaldi

J Immunol· February 2003

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Transgenic overexpression of human IL-17E results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production.
Mee Rhan Kim, Raffi Manoukian, Richard Yeh, Scott M Silbiger, Dimitry M Danilenko, Giorgio Senaldi

Blood· October 2002

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Regulatory effects of novel neurotrophin-1/b cell-stimulating factor-3 (cardiotrophin-like cytokine) on B cell function.
Giorgio Senaldi, Marina Stolina, Jane Guo, Raffaella Faggioni, Susan McCabe

J Immunol· June 2002

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rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease.
Fergus R Byrne, Catherine L Farrell, Richard Aranda, Karen L Rex, Sheila Scully, Giorgio Senaldi

Am J Physiol Gastrointest Liver Physiol· April 2002

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