Publications by authors named "Giusy Laudati"

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MiR-140-3p regulates axonal motor protein KIF5A and contributes to axonal transport degeneration in SMA.
Markella Baklou, Valeria Valsecchi, Giusy Laudati, Xhesika Kolici, Paola Brancaccio

Cell Death Discov· October 2025

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Modulation of ZnT-1 by Let7a unveils a therapeutic potential in amyotrophic lateral sclerosis.
Serenella Anzilotti, Cristina Franco, Valeria Valsecchi, Ornella Cuomo, Giovanna Lombardi, Giusy Laudati

Neurotherapeutics· April 2025

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SMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy.
Valeria Valsecchi, Francesco Errico, Valentina Bassareo, Carmen Marino, Tommaso Nuzzo, Giusy Laudati

Commun Biol· November 2023

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Correction: The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
Valeria Valsecchi, Giusy Laudati, Ornella Cuomo, Rossana Sirabella, Annalisa Del Prete

Cell Death Dis· July 2023

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IN BRAIN POST-ISCHEMIC PLASTICITY, Na/Ca EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE.
Antonella Casamassa, Ornella Cuomo, Anna Pannaccione, Pasquale Cepparulo, Giusy Laudati

Cell Calcium· July 2022

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Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model.
Serenella Anzilotti, Valeria Valsecchi, Paola Brancaccio, Natascia Guida, Giusy Laudati

Neurobiol Dis· November 2021

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The hypoxia sensitive metal transcription factor MTF-1 activates NCX1 brain promoter and participates in remote postconditioning neuroprotection in stroke.
Valeria Valsecchi, Giusy Laudati, Ornella Cuomo, Rossana Sirabella, Annalisa Del Prete

Cell Death Dis· April 2021

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HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage.
Luigi Formisano, Giusy Laudati, Natascia Guida, Luigi Mascolo, Angelo Serani

J Cereb Blood Flow Metab· October 2020

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Transcriptional and epigenetic regulation of ncx1 and ncx3 in the brain.
Luigi Formisano, Natascia Guida, Luigi Mascolo, Angelo Serani, Giusy Laudati

Cell Calcium· May 2020

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Sumoylation of sodium/calcium exchanger in brain ischemia and ischemic preconditioning.
Ornella Cuomo, Antonella Casamassa, Paola Brancaccio, Giusy Laudati, Valeria Valsecchi

Cell Calcium· May 2020

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miR-206 Reduces the Severity of Motor Neuron Degeneration in the Facial Nuclei of the Brainstem in a Mouse Model of SMA.
Valeria Valsecchi, Serenella Anzilotti, Angelo Serani, Giusy Laudati, Paola Brancaccio

Mol Ther· April 2020

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A novel homozygous KCNQ3 loss-of-function variant causes non-syndromic intellectual disability and neonatal-onset pharmacodependent epilepsy.
Anna Lauritano, Sebastien Moutton, Elena Longobardi, Frédéric Tran Mau-Them, Giusy Laudati

Epilepsia Open· September 2019

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Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway.
Giusy Laudati, Luigi Mascolo, Natascia Guida, Rossana Sirabella, Vincenzo Pizzorusso

Neurotoxicology· March 2019

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The miR206-JunD Circuit Mediates the Neurotoxic Effect of Methylmercury in Cortical Neurons.
Natascia Guida, Valeria Valsecchi, Giusy Laudati, Angelo Serani, Luigi Mascolo

Toxicol Sci· June 2018

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The neurotoxicant PCB-95 by increasing the neuronal transcriptional repressor REST down-regulates caspase-8 and increases Ripk1, Ripk3 and MLKL expression determining necroptotic neuronal death.
Natascia Guida, Giusy Laudati, Angelo Serani, Luigi Mascolo, Pasquale Molinaro

Biochem Pharmacol· October 2017

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p38/Sp1/Sp4/HDAC4/BDNF Axis Is a Novel Molecular Pathway of the Neurotoxic Effect of the Methylmercury.
Natascia Guida, Giusy Laudati, Luigi Mascolo, Valeria Valsecchi, Rossana Sirabella

Front Neurosci· January 2017

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MC1568 Inhibits Thimerosal-Induced Apoptotic Cell Death by Preventing HDAC4 Up-Regulation in Neuronal Cells and in Rat Prefrontal Cortex.
Natascia Guida, Giusy Laudati, Luigi Mascolo, Ornella Cuomo, Serenella Anzilotti

Toxicol Sci· December 2016

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Methylmercury upregulates RE-1 silencing transcription factor (REST) in SH-SY5Y cells and mouse cerebellum.
Natascia Guida, Giusy Laudati, Serenella Anzilotti, Rossana Sirabella, Ornella Cuomo

Neurotoxicology· January 2016

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Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death.
Natascia Guida, Giusy Laudati, Serenella Anzilotti, Agnese Secondo, Paolo Montuori

Toxicol Appl Pharmacol· November 2015

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Sp3/REST/HDAC1/HDAC2 Complex Represses and Sp1/HIF-1/p300 Complex Activates ncx1 Gene Transcription, in Brain Ischemia and in Ischemic Brain Preconditioning, by Epigenetic Mechanism.
Luigi Formisano, Natascia Guida, Valeria Valsecchi, Maria Cantile, Ornella Cuomo, Giusy Laudati

J Neurosci· May 2015

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MS-275 inhibits aroclor 1254-induced SH-SY5Y neuronal cell toxicity by preventing the formation of the HDAC3/REST complex on the synapsin-1 promoter.
Luigi Formisano, Natascia Guida, Giusy Laudati, Luigi Mascolo, Gianfranco Di Renzo

J Pharmacol Exp Ther· February 2015

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Extracellular signal-related kinase 2/specificity protein 1/specificity protein 3/repressor element-1 silencing transcription factor pathway is involved in Aroclor 1254-induced toxicity in SH-SY5Y neuronal cells.
Luigi Formisano, Natascia Guida, Giusy Laudati, Francesca Boscia, Alba Esposito

J Neurosci Res· January 2015

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Histone deacetylase 4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di(2-ethylhexyl)phthalate (DEHP), determining neuronal death.
Natascia Guida, Giusy Laudati, Mario Galgani, Marianna Santopaolo, Paolo Montuori

Toxicol Appl Pharmacol· October 2014

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