Publications by authors named "GraZyna Chlon-Rzepa"

Claim this Profile
P
Purine-2,6-dione-based multitarget-directed ligands inhibiting PDE/TRPA1/CHIT1 as a new approach for the treatment of COPD.
Grażyna Chłoń-Rzepa, Katarzyna Wójcik-Pszczoła, Marietta Ślusarczyk, Alicja Gawalska, Adam Bucki

Bioorg Chem· December 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Airway and cardiovascular remodeling in chronic obstructive pulmonary disease (COPD) as a target for transient receptor potential ankyrin 1 (TRPA1) channel modulators.
Natalia Kocot, Elżbieta Pękala, Paulina Koczurkiewicz-Adamczyk, Grażyna Chłoń-Rzepa, Aleksandra Łapa

Bioorg Chem· May 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Advanced pharmacological and pharmacokinetic evaluation of 1,3 dimethylpurine-2,6-dione derivative (GR-14) with prominent mood-modulating activity in rats.
Agnieszka Cios, Grażyna Chłoń-Rzepa, Magdalena Jastrzębska-Więsek, Krzysztof Pociecha, Katarzyna Wójcik-Pszczoła

Pharmacol Rep· February 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacokinetics and Quantitative Structure-Pharmacokinetics Relationship Study of Xanthine Derivatives with Antidepressant, Anti-Inflammatory, and Analgesic Activity in Rats.
Artur Świerczek, Małgorzata Szafarz, Agnieszka Cios, Jan Kobierski, Krzysztof Pociecha

Pharmaceutics· November 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antiplatelet Effects of Selected Xanthine-Based Adenosine A and A Receptor Antagonists Determined in Rat Blood.
Monika Kubacka, Szczepan Mogilski, Marek Bednarski, Krzysztof Pociecha, Artur Świerczek

Int J Mol Sci· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inhaled pan-phosphodiesterase inhibitors ameliorate ovalbumin-induced airway inflammation and remodeling in murine model of allergic asthma.
Katarzyna Wójcik-Pszczoła, Krzysztof Pociecha, Grażyna Chłoń-Rzepa, Monika Zadrożna, Barbara Nowak

Int Immunopharmacol· June 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
In silico and in vitro ADME-Tox analysis and in vivo pharmacokinetic study of representative pan-PDE inhibitors from the group of 7,8-disubstituted derivatives of 1,3-dimethyl-7H-purine-2,6-dione.
Katarzyna Wójcik-Pszczoła, Małgorzata Szafarz, Krzysztof Pociecha, Karolina Słoczyńska, Kamil Piska

Toxicol Appl Pharmacol· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity.
Małgorzata Zygmunt, Marietta Ślusarczyk, Agnieszka Jankowska, Artur Świerczek, Adrian Bryła

Pharmacol Rep· October 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacokinetic/Pharmacodynamic Evaluation of a New Purine-2,6-Dione Derivative in Rodents with Experimental Autoimmune Diseases.
Artur Świerczek, Krzysztof Pociecha, Hanna Plutecka, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa

Pharmaceutics· May 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation.
Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Bruno Ferreira, Paulina Koczurkiewicz-Adamczyk

Pharmaceuticals (Basel)· March 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents.
Katarzyna Wójcik-Pszczoła, Agnieszka Jankowska, Marietta Ślusarczyk, Bogdan Jakieła, Hanna Plutecka

Bioorg Chem· December 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity.
Monika Dąbrowska, Małgorzata Starek, Grażyna Chłoń-Rzepa, Agnieszka Zagórska, Łukasz Komsta

Bioorg Med Chem Lett· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer's Disease.
Agnieszka Jankowska, Grzegorz Satała, Gniewomir Latacz, Anna Partyka, Annamaria Lubelska

Curr Med Chem· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A new class of 5-HT receptor antagonists with procognitive and antidepressant properties.
Agnieszka Jankowska, Grzegorz Satała, Artur Świerczek, Krzysztof Pociecha, Anna Partyka

Future Med Chem· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Diabetic Theory in Anti-Alzheimer's Drug Research and Development. Part 2: Therapeutic Potential of cAMP-Specific Phosphodiesterase Inhibitors.
Agnieszka Jankowska, Maciej Pawłowski, Grażyna Chłoń-Rzepa

Curr Med Chem· June 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Multifunctional Ligands with Glycogen Synthase Kinase 3 Inhibitory Activity as a New Direction in Drug Research for Alzheimer's Disease.
Agnieszka Jankowska, Grzegorz Satała, Andrzej J Bojarski, Maciej Pawłowski, GraŻyna Chłoń-Rzepa

Curr Med Chem· May 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PK/PD Modeling of the PDE7 Inhibitor-GRMS-55 in a Mouse Model of Autoimmune Hepatitis.
Artur Świerczek, Hanna Plutecka, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Elżbieta Wyska

Pharmaceutics· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Diabetic Theory in Anti-Alzheimer's Drug Research and Development - Part 1: Therapeutic Potential of Antidiabetic Agents.
Agnieszka Jankowska, Anna Wesołowska, Maciej Pawłowski, Grażyna Chłoń-Rzepa

Curr Med Chem· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.
Veronika Ručilová, Artur Świerczek, David Vanda, Petr Funk, Barbora Lemrová

Eur J Med Chem· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Advances in the Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 2: Focus on Schizophrenia.
Artur Świerczek, Agnieszka Jankowska, Grażyna Chłoń-Rzepa, Maciej Pawłowski, Elżbieta Wyska

Curr Drug Targets· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT/5-HT receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity.
Agnieszka Jankowska, Grzegorz Satała, Marcin Kołaczkowski, Adam Bucki, Monika Głuch-Lutwin

Eur J Med Chem· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling.
Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk, Paweł E Ferdek

Int J Mol Sci· June 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach.
Artur Świerczek, Krzysztof Pociecha, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Sebastian Baś

Pharm Res· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to: Comparative Assessment of the New PDE7 Inhibitor - GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach.
Artur Świerczek, Krzysztof Pociecha, Marietta Ślusarczyk, Grażyna Chłoń-Rzepa, Sebastian Baś

Pharm Res· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling.
Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Eugenie Ellen, Artur Świerczek

Eur J Pharmacol· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis