Publications by authors named "Graham Macleod"

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CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability.
Jonathan Boucher, Thibault Houles, Elsa Berliocchi, Geneviève Lavoie, Graham MacLeod

Cell Rep· November 2025

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Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils.
Benoît Vanderperre, Amitha Muraleedharan, Marie-France Dorion, Frédérique Larroquette, Esther Del Cid Pellitero, Graham MacLeod

Commun Biol· October 2025

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Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma.
Alexandria DeCarlo, Graham MacLeod, Carolina Fernandes da Silva, Li Qing Shen, Julija Povilaikaite

Cell Rep Med· July 2025

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Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.
Islam E Elkholi, Amélie Robert, Camille Malouf, Joshua L Wu, Hellen Kuasne, Graham Macleod

Cancer Res· June 2025

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PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites.
Manisha Yadav, Mona A AlQazzaz, Felipe E Ciamponi, Jolene C Ho, Maxim I Maron, Graham MacLeod

Nucleic Acids Res· April 2025

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Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation.
Rony Chidiac, Andy Yang, Elli Kubarakos, Nicholas Mikolajewicz, Hong Han, Graham MacLeod

Stem Cell Reports· February 2025

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Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities.
Graham MacLeod, Fatemeh Molaei, Shahan Haider, Maira P Almeida, Sichun Lin

Cancer Res· December 2024

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Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation.
Islam E Elkholi, Amélie Robert, Camille Malouf, Hellen Kuasne, Stanislav Drapela, Graham Macleod

bioRxiv· August 2024

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The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma.
Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin

Cell Death Discov· December 2023

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Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes.
Xian Wang, Zheyuan Gong, Tiancong Wang, Junhui Law, Xin Chen, Graham MacLeod

Sci Adv· March 2023

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Identification of Drug Resistance Mechanisms Using Genome-Wide CRISPR-Cas9 Screens.
Graham MacLeod, Nishani Rajakulendran, Stephane Angers

Methods Mol Biol· July 2022

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A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.
Rony Chidiac, Md Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault

EMBO Mol Med· July 2021

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Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity.
Laura M Richards, Owen K N Whitley, Graham MacLeod, Florence M G Cavalli, Fiona J Coutinho

Nat Cancer· February 2021

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Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival.
Paul Guilhamon, Charles Chesnelong, Michelle M Kushida, Ana Nikolic, Divya Singhal, Graham MacLeod

Elife· January 2021

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Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.
Léo Aubert, Neethi Nandagopal, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Graham Macleod

Nat Commun· July 2020

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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.
Kulandaimanuvel Antony Michealraj, Sachin A Kumar, Leo J Y Kim, Florence M G Cavalli, David Przelicki, Graham MacLeod

Cell· June 2020

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Functional Enhancers Shape Extrachromosomal Oncogene Amplifications.
Andrew R Morton, Nergiz Dogan-Artun, Zachary J Faber, Graham MacLeod, Cynthia F Bartels

Cell· November 2019

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Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.
Nishani Rajakulendran, Katherine J Rowland, Hayden J Selvadurai, Moloud Ahmadi, Nicole I Park, Graham MacLeod

Genes Dev· May 2019

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Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.
Graham MacLeod, Danielle A Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi

Cell Rep· April 2019

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High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.
Ji-Young Youn, Wade H Dunham, Seo Jung Hong, James D R Knight, Mikhail Bashkurov, Graham MacLeod

Mol Cell· February 2018

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SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.
Catherine W N Chiu, Carine Monat, Mélanie Robitaille, Marine Lacomme, Avais M Daulat, Graham Macleod

Dev Cell· January 2016

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High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.
Traver Hart, Megha Chandrashekhar, Michael Aregger, Zachary Steinhart, Kevin R Brown, Graham MacLeod

Cell· December 2015

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Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.
Amanda M Opaluch, Monika Schneider, Chih-yuan Chiang, Quy T Nguyen, Ana M Maestre, Graham MacLeod

PLoS One· January 2015

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PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.
Graham MacLeod, Peng Shang, Gregory T Booth, Lucas A Mastropaolo, Niloufar Manafpoursakha

Reproduction· January 2014

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The application of proteomic approaches to the study of mammalian spermatogenesis and sperm function.
Graham Macleod, Susannah Varmuza

FEBS J· November 2013

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