Publications by authors named "Graham R Moran"

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Electron Pushing: Variants That Alter the Catalytic Distribution of Electrons in Dihydroorotate Dehydrogenase 1B from .
Corine O Smith, Richa Khatiwada, Pengfei Li, Graham R Moran

Biochemistry· September 2025

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The binding modes of quinones in flavoprotein oxidoreductases.
Tyler B Alt, Graham R Moran

Arch Biochem Biophys· August 2025

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Dihydropyrimidine Dehydrogenase from : Evidence for the Catalytic Sequence.
Tyler B Alt, Aj K Croney, Graham R Moran

Biochemistry· August 2025

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Not Once, not Twice, but Thrice: Structure and Catalytic Mechanisms of the Dihydroorotate Dehydrogenases.
Corine O Smith, Graham R Moran

Biochemistry· June 2025

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More Pieces of the Puzzle: Transient State Analysis of Dihydroorotate Dehydrogenase B from .
Corine O Smith, Graham R Moran

Biochemistry· December 2024

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Probing the site of glutathione reduction by thioredoxin/glutathione reductase from Schistosoma mansoni under anaerobic conditions.
Tyler B Alt, Madison M Smith, Graham R Moran

Arch Biochem Biophys· November 2024

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Corrigendum to "Building on a theme: The redox hierarchy of pyridine nucleotide-disulfide oxidoreductases" [Arch. Biochem. Biophys. 755 (2024) 109966].
Madison M Smith, Graham R Moran

Arch Biochem Biophys· September 2024

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Correction to "Design, Synthesis, and Mechanistic Studies of ()-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase".
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Graham R Moran

ACS Chem Biol· August 2024

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Corrigendum: Assigning function to active site residues of thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme.
Madison M Smith, Graham R Moran

Front Mol Biosci· July 2024

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Building on a theme: The redox hierarchy of pyridine nucleotide-disulfide oxidoreductases.
Madison M Smith, Graham R Moran

Arch Biochem Biophys· May 2024

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Design, Synthesis, and Mechanistic Studies of ()-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase.
Allison N Devitt, Abigail L Vargas, Wei Zhu, Benjamin James Des Soye, Fatma Ayaloglu Butun, Graham R Moran

ACS Chem Biol· May 2024

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Elucidation of the Catalytic Sequence of Dihydroorotate Dehydrogenase B from : Evidence for Accumulation of a Flavin Bisemiquinone State in Catalysis.
Corine O Smith, Graham R Moran

Biochemistry· May 2024

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Dihydropyrmidine dehydrogenase from Escherichia coli: Transient state analysis reveals both reductive activation prior to turnover and diminished substrate effector roles relative to the mammalian form.
Tyler B Alt, Matthew R Hoag, Graham R Moran

Arch Biochem Biophys· October 2023

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Assigning function to active site residues of thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme.
Madison M Smith, Graham R Moran

Front Mol Biosci· September 2023

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Descriptive Analysis of Transient-State Observations for Thioredoxin/Glutathione Reductase (Sec597Cys) from .
Madison M Smith, Tyler B Alt, David L Williams, Graham R Moran

Biochemistry· May 2023

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Correction to "Rational Design, Synthesis, and Mechanism of (3,4)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase".
Wei Zhu, Arseniy Butrin, Rafael D Melani, Peter F Doubleday, Glaucio Monteiro Ferreira, Graham R Moran

J Am Chem Soc· May 2023

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The unusual chemical sequences of mammalian dihydropyrimidine dehydrogenase revealed by transient-state analysis.
Madison M Smith, Graham R Moran

Methods Enzymol· May 2023

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Preface.
John P Richard, Graham R Moran

Methods Enzymol· May 2023

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Mammalian dihydropyrimidine dehydrogenase: Added mechanistic details from transient-state analysis of charge transfer complexes.
Madison M Smith, Dariush C Forouzesh, Nicholas E Kaley, Dali Liu, Graham R Moran

Arch Biochem Biophys· March 2023

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Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3,4)-3-Amino-4-fluorocyclopentenecarboxylic Acid.
Sida Shen, Arseniy Butrin, Brett A Beaupre, Glaucio M Ferreira, Peter F Doubleday, Graham R Moran

Molecules· January 2023

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Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis.
Nikola Kenjić, Kathleen M Meneely, Daniel J Wherritt, Melissa C Denler, Timothy A Jackson, Graham R Moran

J Am Chem Soc· July 2022

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Determination of the pH dependence, substrate specificity, and turnovers of alternative substrates for human ornithine aminotransferase.
Arseniy Butrin, Anastassiya Butrin, Zdzislaw Wawrzak, Graham R Moran, Dali Liu

J Biol Chem· June 2022

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Rational Design, Synthesis, and Mechanism of (3,4)-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase.
Wei Zhu, Arseniy Butrin, Rafael D Melani, Peter F Doubleday, Glaucio Monteiro Ferreira, Graham R Moran

J Am Chem Soc· March 2022

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Mammalian dihydropyrimidine dehydrogenase.
Dariush C Forouzesh, Graham R Moran

Arch Biochem Biophys· December 2021

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Finding Ways to Relax: A Revisionistic Analysis of the Chemistry of GTP Cyclohydrolase II.
Madison M Smith, Brett A Beaupre, Dariush C Fourozesh, Kathleen M Meneely, Audrey L Lamb, Graham R Moran

Biochemistry· October 2021

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