Publications by authors named "Greg Markby"

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Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.
Qiyu Tang, Keyi Tang, Greg R Markby, Maciej Parys, Kanchan Phadwal

Autophagy· July 2025

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TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease.
Andrew J McNair, Greg R Markby, Qiyu Tang, Vicky E MacRae, Brendan M Corcoran

Front Vet Sci· October 2023

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TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Qiyu Tang, Greg R Markby, Andrew J MacNair, Keyi Tang, Michal Tkacz

Cell Prolif· June 2023

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New Insights into Molecular Mechanisms Mediating Adaptation to Exercise; A Review Focusing on Mitochondrial Biogenesis, Mitochondrial Function, Mitophagy and Autophagy.
Fiona Louise Roberts, Greg Robert Markby

Cells· October 2021

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Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965.
Danial Ahwazi, Katyayanee Neopane, Greg R Markby, Franziska Kopietz, Ashley J Ovens

Biochem J· August 2021

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Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice.
Fiona L Roberts, Nabil A Rashdan, Kanchan Phadwal, Greg R Markby, Scott Dillon

J Cell Physiol· June 2021

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Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?
Greg Robert Markby, Kei Sakamoto

Am J Physiol Endocrinol Metab· October 2020

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Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep ().
Hiu-Gwen Tsang, Emily L Clark, Greg R Markby, Stephen J Bush, David A Hume

Front Genet· September 2020

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Beyond mineralisation: metabolic functions for matrix mineralisation regulators.
Fiona Roberts, Greg Markby, Scott Dillon, Colin Farquharson, Vicky E MacRae

J Endocrinol· May 2020

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Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling.
Greg R Markby, Vicky E Macrae, Kim M Summers, Brendan M Corcoran

Front Genet· April 2020

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Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration.
Karen Tan, Greg Markby, Rhona Muirhead, Rachel Blake, Lisa Bergeron

PLoS One· March 2020

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Survival of activated myofibroblasts in canine myxomatous mitral valve disease and the role of apoptosis.
Rachel R Blake, Greg R Markby, Geoff J Culshaw, Yolanda Martinez-Pereira, Chi-Chien Lu

Res Vet Sci· February 2020

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Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification.
Cui Lin, Dongxing Zhu, Greg Markby, Brendan M Corcoran, Colin Farquharson

J Vis Exp· November 2017

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Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human.
Greg R Markby, Kim M Summers, Vicky E MacRae, Brendan M Corcoran

Vet Sci· July 2017

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