Publications by authors named "Gregory Amidon"

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Comparative Evaluation of Dissolution Performance in a USP 2 Setup and Alternative Stirrers and Vessel Designs: A Systematic Computational Investigation.
Niloufar Salehi, Jozef Al-Gousous, Bart Hens, Gordon L Amidon, Robert M Ziff, Gregory E Amidon

Mol Pharm· May 2024

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Particle Size, Dose, and Confinement Affect Passive Diffusion Flux through the Membrane Concentration Boundary Layer.
Patrick D Sinko, Niloufar Salehi, Troy Halseth, Pamela J Meyer, Gordon L Amidon, Gregory E Amidon

Mol Pharm· January 2024

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Use of Gastrointestinal Simulator, Mass Transport Analysis, and Absorption Simulation to Investigate the Impact of pH Modifiers in Mitigating Weakly Basic Drugs' Performance Issues Related to Gastric pH: Palbociclib Case Study.
Gislaine Kuminek, Niloufar Salehi, Nicholas M Waltz, David C Sperry, Dale E Greenwood, Gregory E Amidon

Mol Pharm· January 2023

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Evaluating the IVIVC by Combining Tiny-tim Outputs and Compartmental PK Model to Predict Oral Exposure for Different Formulations of Ibuprofen.
Po-Chang Chiang, Jia Liu, Karthik Nagapudi, Ricky Wu, Michael J Dolton, Gregory Amidon

J Pharm Sci· July 2022

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Dissolution Challenges Associated with the Surface pH of Drug Particles: Integration into Mechanistic Oral Absorption Modeling.
Bart Hens, Nidhi Seegobin, Marival Bermejo, Yasuhiro Tsume, Nicola Clear, Gregory E Amidon, Gordon L Amidon

AAPS J· January 2022

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In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior.
Makoto Kataoka, Keiko Minami, Toshihide Takagi, Gregory E Amidon, Shinji Yamashita

Mol Pharm· November 2021

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Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transport Analysis.
Niloufar Salehi, Gislaine Kuminek, Jozef Al-Gousous, David C Sperry, Dale E Greenwood, Gordon L Amidon, Gregory E Amidon

Mol Pharm· September 2021

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Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). , 2020, , 566.
Bart Hens, Marival Bermejo, Patrick Augustijns, Rodrigo Cristofoletti, Gregory E Amidon, Gordon L Amidon

Pharmaceutics· November 2020

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Hierarchical Mass Transfer Analysis of Drug Particle Dissolution, Highlighting the Hydrodynamics, pH, Particle Size, and Buffer Effects for the Dissolution of Ionizable and Nonionizable Drugs in a Compendial Dissolution Vessel.
Niloufar Salehi, Jozef Al-Gousous, Deanna M Mudie, Gordon L Amidon, Robert M Ziff, Gregory E Amidon

Mol Pharm· October 2020

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Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies.
Patrick D Sinko, Sarah Harris, Niloufar Salehi, Pamela J Meyer, Gordon L Amidon, Gregory E Amidon

Mol Pharm· July 2020

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Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b).
Bart Hens, Marival Bermejo, Rodrigo Cristofoletti, Gregory E Amidon, Gordon L Amidon

Pharmaceutics· June 2020

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Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties.
Deanna M Mudie, Nasim Samiei, Derrick J Marshall, Gregory E Amidon, Christel A S Bergström

AAPS J· January 2020

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Mass Transport Analysis of Bicarbonate Buffer: Effect of the CO-HCO Hydration-Dehydration Kinetics in the Fluid Boundary Layer and the Apparent Effective p K Controlling Dissolution of Acids and Bases.
Jozef Al-Gousous, Niloufar Salehi, Gregory E Amidon, Robert M Ziff, Peter Langguth, Gordon L Amidon

Mol Pharm· June 2019

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Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses.
Marival Bermejo, Gislaine Kuminek, Jozef Al-Gousous, Alejandro Ruiz-Picazo, Yasuhiro Tsume, Gregory E Amidon, Gordon L Amidon

Pharmaceutics· March 2019

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Mechanistic Analysis of Cocrystal Dissolution, Surface pH, and Dissolution Advantage as a Guide for Rational Selection.
Fengjuan Cao, Nair Rodriguez-Hornedo, Gregory E Amidon

J Pharm Sci· January 2019

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Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling.
Gregory E Amidon, Bradley D Anderson, Joseph P Balthasar, Christel A S Bergstrom, Shiew-Mei Huang

J Pharm Sci· January 2019

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Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions.
Marival Bermejo, Paulo Paixão, Bart Hens, Yasuhiro Tsume, Mark J Koenigsknecht, Gregory E Amidon, Gordon L Amidon

Mol Pharm· December 2018

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Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.
Paulo Paixão, Marival Bermejo, Bart Hens, Yasuhiro Tsume, Joseph Dickens, Gregory E Amidon, Gordon L Amidon

Mol Pharm· December 2018

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Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate-CO Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance.
Jozef Al-Gousous, Kathy X Sun, Daniel P McNamara, Bart Hens, Niloufar Salehi, Gregory E Amidon, Gordon L Amidon

Mol Pharm· November 2018

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Formulation predictive dissolution (fPD) testing to advance oral drug product development: An introduction to the US FDA funded '21st Century BA/BE' project.
Bart Hens, Patrick D Sinko, Nicholas Job, Meagan Dean, Jozef Al-Gousous, Gregory E Amidon, Gordon L Amidon

Int J Pharm· September 2018

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In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance.
Yasuhiro Tsume, Sanjaykumar Patel, Nikoletta Fotaki, Christel Bergstrӧm, Gordon L Amidon, Gregory E Amidon

AAPS J· September 2018

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Gastric emptying and intestinal appearance of nonabsorbable drugs phenol red and paromomycin in human subjects: A multi-compartment stomach approach.
Paulo Paixão, Marival Bermejo, Bart Hens, Yasuhiro Tsume, Joseph Dickens, Gregory E Amidon, Gordon L Amidon

Eur J Pharm Biopharm· August 2018

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Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.
Bart Hens, Marival Bermejo, Yasuhiro Tsume, Isabel Gonzalez-Alvarez, Hao Ruan, Gregory E Amidon, Gordon L Amidon

Eur J Pharm Sci· March 2018

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Mechanistic Basis of Cocrystal Dissolution Advantage.
Fengjuan Cao, Gordon L Amidon, Naír Rodríguez-Hornedo, Gregory E Amidon

J Pharm Sci· January 2018

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In Vitro Characterization of the Biomimetic Properties of Poly(dimethylsiloxane) To Simulate Oral Drug Absorption.
Patrick D Sinko, David Gidley, Richard Vallery, Aaron Lamoureux, Gordon L Amidon, Gregory E Amidon

Mol Pharm· December 2017

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