Publications by authors named "Gregory D Jay"

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The Actin Cytoskeleton as a Regulator of Proteoglycan 4.
Sofia Gonzalez-Nolde, Cameron J Schweiger, Elizabeth E R Davis, Thomas J Manzoni, Samer M I Hussein, Gregory D Jay

Cartilage· September 2025

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Mesenchymal progenitor-derived proteoglycan 4 regulates the transdifferentiation of chondrocytes into osteoblasts during fracture healing.
Nicoletta Ninkovic, Jessica May Corpuz, Alana Stahl, Alexandra Olsen, Colton M Unger, Gregory D Jay

Stem Cells Transl Med· September 2025

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Proteoglycan-4 (PRG4) serum concentration is lower in aged mice, and genetic deficiency impacts survival probability, blood parameters, and bone during aging.
Adam P Tanguay, Nikhil G Menon, Emma Slavin, Mikayla Moody, Erin McEwen, Gregory D Jay

Geroscience· June 2025

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Lubricin's Mucin Domain Has Strong Polyproline Type-II Helical Character.
Bibo 'Noah' Feng, Ava J Marks, Faith Kim, Mandar Naik, Tannin A Schmidt, Gregory D Jay

bioRxiv· June 2025

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Glycoproteoforms of Osteoarthritis-associated Lubricin in Plasma and Synovial Fluid.
Ali Reza Afshari, Vincent Chang, Kristina A Thomsson, Jennifer Höglund, Elizabeth N Browne, Gregory D Jay

Mol Cell Proteomics· March 2025

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Proteoglycan 4 (Lubricin) and regulation of xanthine oxidase in synovial macrophage as a mechanism of controlling synovitis.
Khaled A Elsaid, Ling X Zhang, Thomas Zhao, Ava Marks, Derek Jenkins, Gregory D Jay

Arthritis Res Ther· December 2024

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Proteoglycan 4 (Lubricin) and Regulation of Xanthine Oxidase in Synovial Macrophage as A Mechanism of Controlling Synovitis.
Khaled A Elsaid, Ling X Zhang, Thomas Zhao, Ava Marks, Derek Jenkins, Gregory D Jay

Res Sq· September 2024

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PRG4 deficiency in mice alters skeletal structure, mechanics, and calvarial osteoclastogenesis, and rhPRG4 inhibits in vitro osteoclastogenesis.
Adam P Tanguay, Nikhil G Menon, Margaret H Boudreau, Sandra Jastrzebski, Paige S Woods, Gregory D Jay

J Orthop Res· June 2024

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Dissolvable Immunomodulatory Microneedles for Treatment of Skin Wounds.
Pejman Ghelich, Mohamadmahdi Samandari, Alireza Hassani Najafabadi, Adam Tanguay, Jacob Quint, Gregory D Jay

Adv Healthc Mater· June 2024

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Scale-Dependent Rheology of Synovial Fluid Lubricating Macromolecules.
Leonardo Martin-Alarcon, Aleksandra Govedarica, Randy H Ewoldt, Steven L Bryant, Gregory D Jay

Small· May 2024

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Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice.
Menno Hoekstra, Olga S C Snip, Philip Janusz, Mireia N A Bernabé Kleijn, Edward R Truitt, Gregory D Jay

J Physiol· May 2024

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Prediction of anemia in real-time using a smartphone camera processing conjunctival images.
Leon Zhao, Alisa Vidwans, Courtney J Bearnot, James Rayner, Timmy Lin, Gregory D Jay

PLoS One· May 2024

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A structural and functional comparison between two recombinant human lubricin proteins: Recombinant human proteoglycan-4 (rhPRG4) vs ECF843.
Nikhil G Menon, Adam P Tanguay, Libo Zhou, Ling X Zhang, Cedric E Bobst, Gregory D Jay

Exp Eye Res· October 2023

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Plasma proteoglycan 4: a novel biomarker for acute lung injury after pediatric cardiac surgery.
Ahmed Asfari, Erica A Doyle, Gregory D Jay, Natalia Aristizabal, Ananya Manchikalapati

Transl Pediatr· September 2023

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Evaluation of microMend wound closure device in repairing skin lacerations.
Tarek Nizami, Francesca Beaudoin, Selim Suner, Adam Aluisio, Reena A Bhatt, Gregory D Jay

Emerg Med J· August 2023

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Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia.
Khaled Elsaid, Tony R Merriman, Leigh-Ana Rossitto, Ru Liu-Bryan, Jacob Karsh, Gregory D Jay

Arthritis Rheumatol· May 2023

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Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis.
Nabangshu Das, Luiz G N de Almeida, Afshin Derakhshani, Daniel Young, Kobra Mehdinejadiani, Gregory D Jay

Nat Commun· April 2023

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Noncovalent hyaluronan crosslinking by TSG-6: Modulation by heparin, heparan sulfate, and PRG4.
Yun Jin Ashley Sin, Rebecca MacLeod, Adam P Tanguay, Andrew Wang, Olivia Braender-Carr, Gregory D Jay

Front Mol Biosci· October 2022

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Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells.
Nikhil G Menon, Yasir Suhail, Ruchi Goyal, Wenqiang Du, Adam P Tanguay, Gregory D Jay

Int J Mol Sci· October 2022

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Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1: Interplay between -linked glycosylation and inflammatory cytokines.
Shan Huang, Kristina A Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, Gregory D Jay

Front Mol Biosci· September 2022

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Quadruped Gait and Regulation of Apoptotic Factors in Tibiofemoral Joints following Intra-Articular rhPRG4 Injection in Null Mice.
Daniel S Yang, Edward E Dickerson, Ling X Zhang, Holly Richendrfer, Padmini N Karamchedu, Gregory D Jay

Int J Mol Sci· April 2022

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Recombinant Human Proteoglycan 4 Regulates Phagocytic Activation of Monocytes and Reduces IL-1β Secretion by Urate Crystal Stimulated Gout PBMCs.
Sandy ElSayed, Gregory D Jay, Ralph Cabezas, Marwa Qadri, Tannin A Schmidt

Front Immunol· February 2022

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Efficient Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from Exhaled Breath.
Chaorui Duan, Luke Buerer, Jing Wang, Samuel Kaplan, Gavin Sabalewski, Gregory D Jay

J Mol Diagn· December 2021

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Proteomics Analysis of Tears and Saliva From Sjogren's Syndrome Patients.
Nabangshu Das, Nikhil G Menon, Luiz G N de Almeida, Paige S Woods, Miriam L Heynen, Gregory D Jay

Front Pharmacol· December 2021

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Correction to: Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration.
Marwa Qadri, Gregory D Jay, Ling X Zhang, Tannin A Schmidt, Jennifer Totonchy

Arthritis Res Ther· October 2021

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