Publications by authors named "Gregory J Digby"

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G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Masoud Ghamari-Langroudi, Gregory J Digby, Julien A Sebag, Glenn L Millhauser, Rafael Palomino

Nature· April 2015

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The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
Brandon L Panaro, Iain R Tough, Maja S Engelstoft, Robert T Matthews, Gregory J Digby

Cell Metab· December 2014

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Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.
Douglas J Sheffler, Christian Sevel, Uyen Le, Kimberly M Lovell, James C Tarr, Gregory J Digby

Bioorg Med Chem Lett· January 2013

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Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.
Gregory J Digby, Thomas J Utley, Atin Lamsal, Christian Sevel, Douglas J Sheffler

ACS Chem Neurosci· December 2012

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Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Gregory J Digby, Meredith J Noetzel, Michael Bubser, Thomas J Utley, Adam G Walker

J Neurosci· June 2012

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Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.
Evan P Lebois, Gregory J Digby, Douglas J Sheffler, Bruce J Melancon, James C Tarr

Bioorg Med Chem Lett· November 2011

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Orthosteric- and allosteric-induced ligand-directed trafficking at GPCRs.
Gregory J Digby, P Jeffrey Conn, Craig W Lindsley

Curr Opin Drug Discov Devel· September 2010

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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.
Gregory J Digby, Jana K Shirey, P Jeffrey Conn

Mol Biosyst· August 2010

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The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers.
Bettye Hollins, Sudhakiranmayi Kuravi, Gregory J Digby, Nevin A Lambert

Cell Signal· June 2009

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GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.
Muthusamy Thangaraju, Gail A Cresci, Kebin Liu, Sudha Ananth, Jaya P Gnanaprakasam, Gregory J Digby

Cancer Res· April 2009

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A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
Francis S Willard, Zhen Zheng, Juan Guo, Gregory J Digby, Adam J Kimple

J Biol Chem· December 2008

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Differential dissociation of G protein heterotrimers.
Gregory J Digby, Pooja R Sethi, Nevin A Lambert

J Physiol· July 2008

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Some G protein heterotrimers physically dissociate in living cells.
Gregory J Digby, Robert M Lober, Pooja R Sethi, Nevin A Lambert

Proc Natl Acad Sci U S A· November 2006

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