Publications by authors named "Gregory L Moore"

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A B7-H3-Targeted CD28 Bispecific Antibody Enhances the Activity of Anti-PD-1 and CD3 T-cell Engager Immunotherapies.
Gregory L Moore, Veronica G Zeng, Juan E Diaz, Christine Bonzon, Kendra N Avery

Mol Cancer Ther· March 2025

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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer.
Olivier Nolan-Stevaux, Cong Li, Lingming Liang, Jinghui Zhan, Juan Estrada, Gregory L Moore

Cancer Discov· January 2024

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Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release.
Christina L Zuch de Zafra, Flordeliza Fajardo, Wendy Zhong, Matthew J Bernett, Umesh S Muchhal, Gregory L Moore

Clin Cancer Res· July 2019

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A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats.
Gregory L Moore, Matthew J Bernett, Rumana Rashid, Erik W Pong, Duc-Hanh T Nguyen

Methods· February 2019

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Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn.
Matthew J Bernett, Seung Y Chu, Irene Leung, Gregory L Moore, Sung-Hyung Lee

MAbs· April 2015

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A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens.
Gregory L Moore, Cristina Bautista, Erik Pong, Duc-Hanh T Nguyen, Jonathan Jacinto

MAbs· June 2012

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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody.
Seung Y Chu, Holly M Horton, Erik Pong, Irene W L Leung, Hsing Chen, Gregory L Moore

J Allergy Clin Immunol· April 2012

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Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb.
Saso Cemerski, Seung Y Chu, Gregory L Moore, Umesh S Muchhal, John R Desjarlais

Immunol Lett· March 2012

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Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions.
Gregory L Moore, Hsing Chen, Sher Karki, Greg A Lazar

MAbs· July 2011

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Engineering fully human monoclonal antibodies from murine variable regions.
Matthew J Bernett, Sher Karki, Gregory L Moore, Irene W L Leung, Hsing Chen

J Mol Biol· March 2010

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Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies.
Seung Y Chu, Igor Vostiar, Sher Karki, Gregory L Moore, Greg A Lazar

Mol Immunol· September 2008

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IPRO: an iterative computational protein library redesign and optimization procedure.
Manish C Saraf, Gregory L Moore, Nina M Goodey, Vania Y Cao, Stephen J Benkovic

Biophys J· June 2006

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Using multiple sequence correlation analysis to characterize functionally important protein regions.
Manish C Saraf, Gregory L Moore, Costas D Maranas

Protein Eng· June 2003

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Identifying residue-residue clashes in protein hybrids by using a second-order mean-field approach.
Gregory L Moore, Costas D Maranas

Proc Natl Acad Sci U S A· April 2003

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Predicting out-of-sequence reassembly in DNA shuffling.
Gregory L Moore, Costas D Maranas

J Theor Biol· November 2002

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eCodonOpt: a systematic computational framework for optimizing codon usage in directed evolution experiments.
Gregory L Moore, Costas D Maranas

Nucleic Acids Res· June 2002

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