Publications by authors named "Guanghao Zhu"

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Isoliquiritigenin attenuates cisplatin-induced hearing loss and ototoxicity by activating the Keap1-Nrf2-ARE pathway.
Ying Chen, Xiaoyang Luo, Yanyan Deng, Guanghao Zhu, Xiayan Chu, Jingjing Zhu

Free Radic Biol Med· December 2025

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The Identification and Synthesis of New Sea Cucumber Peptides Leveraging Peptidomics Technology, along with their Anti-Parkinson's Disease Efficacy.
Jiawei Liu, Yusheng Shi, Lingling Jin, Baixue Sun, Ruonan Wang, Guanghao Zhu

J Neuroimmune Pharmacol· October 2025

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Discovery of orally active and serine-targeting covalent inhibitors against hCES2A for ameliorating irinotecan-triggered gut toxicity.
Ya Zhang, Yufan Fan, Yunqing Song, Guanghao Zhu, Xinjuan Li

Acta Pharm Sin B· October 2025

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Madecassoside exerts anti-neurodegeneration effects in protein l-isoaspartyl methyltransferase deficient mice via targeting PRDX2-mediated oxidative stress and inflammation.
Wanyu Zhong, Guanghao Zhu, Dingzhuo Lu, Linmei Wang, Binyuan Zhang

Biochem Pharmacol· September 2025

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Thiazole-fused thiazoliniums with ketone warheads as covalent inhibitors targeting Cys44 of SARS-CoV-2 3CL.
Qizhen Cao, Zhaoqin Zhang, Guanghao Zhu, Sanfeng Dong, Xue Sun, Weiliang Zhu

Chem Biol Interact· September 2025

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Discovery of a novel chalcone-derived covalent Keap1 binder for mitigating cisplatin-induced mitochondrial dysfunction and nephrotoxicity.
Yanyan Deng, Leizhi Xu, Zhengtao Jiang, Lin Chen, Guanghao Zhu

Redox Biol· September 2025

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Bioassay-guided evaluation of a potent dual inhibitor of host and gut microbial α-glucosidases from Galla chinensis: mechanism insights and in silico studies.
Hao-Fan Sun, Tong Yang, Yu-Tong Liu, Dong-Ning Kang, Guang-Hao Zhu

Fitoterapia· September 2025

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Discovery of baicalein derivatives as novel covalent inhibitors of SARS CoV-2 M: Structure-activity relationships and inhibitory mechanisms.
Zhao-Qin Zhang, Guang-Hao Zhu, Rong Zhu, Jing-Xuan Lei, Shu-Yan Liu, Dong-Zhu Tu, Xiao-Yu Zhuang

Bioorg Chem· July 2025

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Pectolinarigenin mitigates 5-FU-induced intestinal mucositis via suppressing ferroptosis through activating PPARγ/GPX4 signaling.
Xin Ge, Yi-Zhe Fan, Yanyan Deng, Yutao Chen, Jian Gao, Guanghao Zhu

Phytomedicine· July 2025

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Channel attention pyramid network for remote physiological measurement.
Jing Zhang, Haixin Sun, Yuhao Hu, Guanghao Zhu, Fang Liu

Sci Rep· July 2025

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Locoregional Immune Checkpoint Blockade and Remodeling of Lymph Nodes by Engineered Dendritic Cell-Derived Exosomes for Suppressing Tumor Progression and Metastasis.
Yizhen Wang, Xiaomin Guo, Jingya Qin, Yifan Xue, Peng Zhang, Guanghao Zhu

Adv Sci (Weinh)· June 2025

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An optimized CYP3A4-activatable fluorogenic sensor for functional imaging and multi-dimensional inhibitor assessment.
Feng Zhang, Yufan Fan, Mei Luo, Jian Huang, Bei Zhao, Guanghao Zhu

Chem Sci· June 2025

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Rational engineering of isoform-specific hSULT1E1 fluorogenic substrates for functional analysis and inhibitor screening.
Xiaoting Niu, Yufan Fan, Guanghao Zhu, Hairong Zeng, Bei Zhao

Biosens Bioelectron· May 2025

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Manipulations of a transmon qubit with a null-biased electro-optic fiber link.
Wenqu Xu, Tingting Guo, Kaixuan Zhang, Zishuo Li, Tianshi Zhou, Jiyuan Zhu, Guanghao Zhu, Guozhu Sun

Nat Commun· March 2025

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Uncovering the naturally occurring covalent inhibitors of SARS-CoV-2 M from the Chinese medicine sappanwood and deciphering their synergistic anti-M effects.
Qing Hu, Yi-Wen Zhang, Ya-Ni Zhang, Guang-Hao Zhu, Peng-Cheng Chen

J Ethnopharmacol· February 2025

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Hinokiflavone from Platycladi cacumen as a potent broad-spectrum inhibitor of gut microbial Loop-1 β-glucuronidases: Inhibition kinetics and molecular simulation.
Yue Han, Yu-Tong Liu, Lu Chen, Hao-Fan Sun, Guang-Hao Zhu

Chem Biol Interact· December 2024

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Discovery of Tetrahydro Tanshinone I as a Naturally Occurring Covalent -Inhibitor Against Gut Microbial Bile Salt Hydrolases.
Xue-Zhang, Chun-Yu Li, Guang-Hao Zhu, Li-Lin Song, Yi-Wen Zhao

J Agric Food Chem· October 2024

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Therapeutic effect of E-Lip-siRNA-sFlt1 on pre-eclampsia: targeted gene silencing and improved pregnancy outcomes.
Jinhua Dong, Yingying Zhang, Jingsheng Zhou, Shuhui Mao, Jianfen Tang, Guanghao Zhu

Nanomedicine (Lond)· September 2024

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Role of tympanocentesis in the prevention of middle ear barotrauma induced by fast buoyant ascent escape from 200 m underwater.
Xu Liu, Hengrong Yuan, Jieying Peng, Guanghao Zhu, Nan Wang

Diving Hyperb Med· September 2024

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Discovery and characterization of naturally occurring covalent inhibitors of SARS-CoV-2 M from the antiviral herb Ephedra.
Qing Hu, Yiwen Zhang, Pengcheng Chen, Yani Zhang, Guanghao Zhu

Chin J Nat Med· September 2024

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Discovery of baicalein derivatives as novel inhibitors against human pancreatic lipase: Structure-activity relationships and inhibitory mechanisms.
Xiao-Ya Qin, Rong Zhu, Xu-Dong Hou, Guang-Hao Zhu, Min Zhang

Int J Biol Macromol· August 2024

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Long noncoding RNA MALAT1 as a ceRNA drives mouse fibroblast activation via the miR-335-3p/P2ry2 axis.
Mengjie Chen, Jieying Peng, Guanghao Zhu, Cunhui Qian, Zhi Xiao

PLoS One· August 2024

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Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1CD206 pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis.
Jing Zhou, Qing Song, Haoze Li, Yicun Han, Yunzhou Pu, Guanghao Zhu, Huirong Zhu

Mol Cancer· August 2024

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Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB.
Chun-Lan Xie, Hong-Xiu Xiao, Pei-Fang Song, Qing-Mei Liu, Haoxiang Wei, Guang-Hao Zhu

J Med Chem· May 2024

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New strategy for intraoperative phonosurgical management of recurrent laryngeal nerve infiltrated by thyroid carcinoma.
Jieying Peng, Guanghao Zhu, Yingna Gao, Xianmin Song, Haojun Yu

Langenbecks Arch Surg· April 2024

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