Publications by authors named "Guillermo Leon"

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Design, development and preclinical assessment of MENAVip-ICP, a new snake antivenom with potential coverage of species in the Middle East and North Africa regions.
Álvaro Segura, Edwin Moscoso, Deibid Umaña, Mariángela Vargas, Andrés Sánchez

Toxicon X· December 2024

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Stress levels, hematological condition, and productivity of plasma-producing horses used for snake antivenom manufacture: A comparison of two industrial bleeding methods.
Ana Margarita Arias-Esquivel, Edwin Moscoso, Deibid Umaña, Mauricio Arguedas, Daniela Solano

Toxicon X· December 2024

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A polygeneric immunogen composed of 22 venoms from sub-Saharan African snakes to expand the neutralization scope of the EchiTAb-plus-ICP antivenom.
Andrés Sánchez, Gina Durán, Maykel Cerdas, Jairo Gutiérrez, Álvaro Segura

Toxicon X· December 2024

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Pilot-scale evaluation of a dynamic body-feed filtration system for primary clarification of snake antivenoms produced by the caprylic acid method.
Andrés Sánchez, Maykel Cerdas, Jairo Gutiérrez, Mariángela Vargas, Álvaro Segura

Toxicon X· September 2024

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Assessment of the toxicity assay as a substitute of the mouse lethality assay in the determination of venom-induced toxicity and preclinical efficacy of antivenom.
Xavier Araya, Mitchel Okumu, Gina Durán, Aarón Gómez, José María Gutiérrez

Toxicon X· June 2024

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Comparison of the intrageneric neutralization scope of monospecific, bispecific/monogeneric and polyspecific/monogeneric antisera raised in horses immunized with sub-Saharan African snake venoms.
Andrés Sánchez, Gina Durán, Álvaro Segura, María Herrera, Mariángela Vargas

PLoS Negl Trop Dis· May 2024

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Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of mamba (Elapidae: spp.) snakes.
Aarón Gómez, Andrés Sánchez, Gina Durán, Mauren Villalta, Álvaro Segura

Toxicon X· March 2024

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Analysis of commercially available snake antivenoms reveals high contents of endotoxins in some products.
Gabriela Solano, Stuart Ainsworth, Adriana Sánchez, Mauren Villalta, Paola Sánchez

Toxicon X· March 2024

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African polyvalent antivenom can maintain pharmacological stability and ability to neutralise murine venom lethality for decades post-expiry: evidence for increasing antivenom shelf life to aid in alleviating chronic shortages.
Gabriela Solano, Sinead Cunningham, Rebecca J Edge, Gina Duran, Adriana Sanchez

BMJ Glob Health· March 2024

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Physicochemical and immunological effects of adjuvant formulations with snake venom antigens for immunization of horses for antivenom production.
Christopher B Fox, Amit P Khandhar, Lisa Khuu, Tony Phan, Robert Kinsey

Toxicon· August 2023

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Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Naja spp. African snakes.
Aarón Gómez, Andrés Sánchez, Gina Durán, Mauren Villalta, Álvaro Segura

PLoS Negl Trop Dis· August 2023

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Clinical effects of immunization, bleeding, and albumin-based fluid therapy in horses used as immunoglobulin source to produce a polyspecific antivenom (Echitab-plus-ICP) towards venoms of African snakes.
Rose Mary Huertas, Mauricio Arguedas, Juan Manuel Estrada, Edwin Moscoso, Deibid Umaña

Toxicon X· June 2023

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Comparison of adjuvant emulsions for their safety and ability to enhance the antibody response in horses immunized with African snake venoms.
Mauricio Arguedas, Deibid Umaña, Edwin Moscoso, Armando García, Carolina Pereira

Vaccine X· December 2022

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Incidence and Prognostic Significance of High-Risk Cytogenetically Abnormalities in Multiple Myeloma Patients in Colombia.
Juan Felipe Combariza, Rocío Ordúz, Claudia Agudelo, Sonia Hernandez, Ana María Madera, Leonardo Bautista

Clin Lymphoma Myeloma Leuk· August 2022

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Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. and Echis spp. African snakes.
Aarón Gómez, Andrés Sánchez, Gina Durán, Daniel Cordero, Álvaro Segura

PLoS Negl Trop Dis· August 2022

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Characterization of Anti-SARS-CoV-2 Intravenous Immunoglobulins (IVIg) Produced From Plasma of Donors Immunized With the BNT162b2 Vaccine and Its Comparison With a Similar Formulation Produced From Plasma of COVID-19 Convalescent Donors.
Gabriel Rojas-Jiménez, Daniela Solano, Álvaro Segura, Andrés Sánchez, Stephanie Chaves-Araya

Front Med Technol· January 2022

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Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms.
Gina Durán, Gabriela Solano, Aarón Gómez, Daniel Cordero, Adriana Sánchez

Toxicon X· November 2021

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Intraspecific variability of the Central American rattlesnake (Crotalus simus) venom and its usefulness to obtain a representative standard venom.
Aarón Gómez, Gabriela Solano, Arturo Chang-Castillo, Danilo Chacón, Greivin Corrales

Toxicon· October 2021

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High Efficacy of Therapeutic Equine Hyperimmune Antibodies Against SARS-CoV-2 Variants of Concern.
Andres Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján, Eugenia Corrales-Aguilar

Front Med (Lausanne)· September 2021

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Heterologous Hyperimmune Polyclonal Antibodies Against SARS-CoV-2: A Broad Coverage, Affordable, and Scalable Potential Immunotherapy for COVID-19.
Alberto Alape-Girón, Andrés Moreira-Soto, Mauricio Arguedas, Hebleen Brenes, Willem Buján

Front Med (Lausanne)· September 2021

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Expanding the neutralization scope of the Central American antivenom (PoliVal-ICP) to include the venom of Crotalus durissus pifanorum.
Adriana Alfaro-Chinchilla, Álvaro Segura, Aarón Gómez, Cecilia Díaz, Greivin Corrales

J Proteomics· August 2021

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Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles.
José María Gutiérrez, Mariángela Vargas, Álvaro Segura, María Herrera, Mauren Villalta

Front Immunol· June 2021

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Comparative venomics and preclinical efficacy evaluation of a monospecific Hemachatus antivenom towards sub-Saharan Africa cobra venoms.
Andrés Sánchez, Álvaro Segura, Davinia Pla, José Munuera, Mauren Villalta

J Proteomics· May 2021

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Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19.
Guillermo León, María Herrera, Mariángela Vargas, Mauricio Arguedas, Andrés Sánchez

Sci Rep· May 2021

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Measurable Residual Disease Assessment and Allogeneic Transplantation as Consolidation Therapy in Adult Acute Lymphoblastic Leukemia in Colombia.
Juan Felipe Combariza, Marcos Arango, Laura Díaz, Claudia Agudelo, Sonia Hernandez, Leonardo Bautista

Clin Lymphoma Myeloma Leuk· April 2021

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