Publications by authors named "Guohuang Fan"

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MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression.
Sijia Liu, Binle Tian, Na Wang, Zhilong Wang, Wen Zhang, Guo-Huang Fan

Cell Death Discov· July 2025

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CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype.
Binle Tian, Zhilong Wang, Mei Cao, Na Wang, Xuebing Jia, Guo-Huang Fan

J Exp Clin Cancer Res· April 2025

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Correction: The JAK-STAT pathway: from structural biology to cytokine engineering.
You Lv, Jianxun Qi, Jeffrey J Babon, Longxing Cao, Guohuang Fan

Signal Transduct Target Ther· October 2024

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Cryo-EM Structure and Biochemical Analysis of the Human Chemokine Receptor CCR8.
Qi Peng, Haihai Jiang, Xinyu Cheng, Na Wang, Sili Zhou, Guo-Huang Fan

Biochemistry· August 2024

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The JAK-STAT pathway: from structural biology to cytokine engineering.
You Lv, Jianxun Qi, Jeffrey J Babon, Longxing Cao, Guohuang Fan

Signal Transduct Target Ther· August 2024

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Small molecule drug discovery targeting the JAK-STAT pathway.
You Lv, Pengbing Mi, Jeffrey J Babon, Guohuang Fan, Jianxun Qi

Pharmacol Res· June 2024

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The Tautomerase Activity of Tumor Exosomal MIF Promotes Pancreatic Cancer Progression by Modulating MDSC Differentiation.
Xuebing Jia, Jianbei Xi, Binle Tian, Yuanyuan Zhang, Zhilong Wang, Fan Wang, Guo-Huang Fan

Cancer Immunol Res· January 2024

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Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis.
Jianbei Xi, Hongliang Gong, Zheng Li, Yue Li, Yong Wu, Guo-Huang Fan

J Med Chem· December 2023

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Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy.
Yue Li, Yuanyuan Liu, Yong Zhang, Yong Wu, Zili Xing, Guo-Huang Fan

J Med Chem· September 2023

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Discovery of a Potent and Selective CCR8 Small Molecular Antagonist IPG7236 for the Treatment of Cancer.
Yong Wu, Jianbei Xi, Yue Li, Zheng Li, Yong Zhang, Guo-Huang Fan

J Med Chem· April 2023

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Lentiviral-mediated knock-down of GD3 synthase protects against MPTP-induced motor deficits and neurodegeneration.
Anandh Dhanushkodi, Yi Xue, Emily E Roguski, Yun Ding, Shannon G Matta, Guo-Huang Fan

Neurosci Lett· January 2019

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AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism.
Chun Song, Han Yan, Hanming Wang, Yan Zhang, Huiqing Cao, Guohuang Fan

J Genet Genomics· February 2018

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RTL1 promotes melanoma proliferation by regulating Wnt/β-catenin signalling.
Guobiao Fan, Dan Ye, Songcheng Zhu, Jiajie Xi, Xudong Guo, Guohuang Fan

Oncotarget· December 2017

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Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes.
Weihua Zhao, David R Beers, Kristopher G Hooten, Douglas H Sieglaff, Aijun Zhang, Guo-Huang Fan

JAMA Neurol· June 2017

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CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease.
Xiao-Fang Zhang, Yan-Feng Zhao, Shun-Wei Zhu, Wei-Jie Huang, Yan Luo, Guo-Huang Fan

J Alzheimers Dis· July 2016

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Deficiency of macrophage migration inhibitory factor attenuates tau hyperphosphorylation in mouse models of Alzheimer's disease.
Shu-Qin Li, Yang Yu, Jin-Zhao Han, Ding Wang, Jin Liu, Guo-Huang Fan

J Neuroinflammation· September 2015

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Roles of resolvins in the resolution of acute inflammation.
Qing Qu, Wenjuan Xuan, Guo-Huang Fan

Cell Biol Int· January 2015

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The chemotaxis of M1 and M2 macrophages is regulated by different chemokines.
Wenjuan Xuan, Qing Qu, Biao Zheng, Sidong Xiong, Guo-Huang Fan

J Leukoc Biol· January 2015

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Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.
Dean Y Maeda, Angela M Peck, Aaron D Schuler, Mark T Quinn, Liliya N Kirpotina, Guo-Huang Fan

J Med Chem· October 2014

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Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events.
Xiaohong Xu, Ying Lei, Jie Luo, Jamie Wang, Shu Zhang, Guohuang Fan

Stem Cell Res· March 2013

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Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1α, suppress amyloid β-induced neurotoxicity.
Dayanidhi Raman, Snjezana-Zaja Milatovic, Dejan Milatovic, Ryan Splittgerber, Guo-Huang Fan

Toxicol Appl Pharmacol· November 2011

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Apolipoprotein E-Deficient Lipoproteins Induce Foam Cell Formation by Activation of PERK-EIF-2α Signaling Cascade.
Yanfeng Zhao, Zhongmao Guo, Xinghua Lin, Lichun Zhou, Emmanuel U Okoro, Guohuang Fan

J Bioanal Biomed· October 2010

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Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's disease.
Yun Ding, Aimin Qiao, Guo-Huang Fan

Neurobiol Dis· August 2010

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Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation.
Marjelo A Mines, J Shawn Goodwin, Lee E Limbird, Fei-Fei Cui, Guo-Huang Fan

J Biol Chem· February 2009

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Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.
Yun Ding, Aimin Qiao, Ziqing Wang, J Shawn Goodwin, Eun-Sook Lee, Guo-Huang Fan

J Neurosci· November 2008

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