Publications by authors named "Guy Werlen"

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Food for thought: Nutrient metabolism controlling early T cell development.
Guy Werlen, Tatiana Hernandez, Estela Jacinto

Bioessays· January 2025

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Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis.
Oak Z Chi, Xia Liu, Harvey Fortus, Guy Werlen, Estela Jacinto

Neuromolecular Med· April 2024

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The Hexosamine Biosynthesis Pathway: Regulation and Function.
Alysta Paneque, Harvey Fortus, Julia Zheng, Guy Werlen, Estela Jacinto

Genes (Basel)· April 2023

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Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis.
Guy Werlen, Mei-Ling Li, Luca Tottone, Victoria da Silva-Diz, Xiaoyang Su

Nat Commun· December 2022

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The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane.
Mei-Ling Li, Aparna Ragupathi, Nikhil Patel, Tatiana Hernandez, Jedrick Magsino, Guy Werlen

J Biol Chem· October 2022

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MTOR Signaling and Metabolism in Early T Cell Development.
Guy Werlen, Ritika Jain, Estela Jacinto

Genes (Basel)· May 2021

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mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation.
Po-Chien Chou, Swati Rajput, Xiaoyun Zhao, Chadni Patel, Danielle Albaciete, Guy Werlen

Cells· June 2020

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mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation.
Joseph G Moloughney, Nicole M Vega-Cotto, Sharon Liu, Chadni Patel, Peter K Kim, Guy Werlen

J Biol Chem· October 2018

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mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1.
Joseph G Moloughney, Peter K Kim, Nicole M Vega-Cotto, Chang-Chih Wu, Sisi Zhang, Guy Werlen

Mol Cell· September 2016

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Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development.
Po-Chien Chou, Won Jun Oh, Chang-Chih Wu, Joseph Moloughney, Markus A Rüegg, Guy Werlen

J Immunol· August 2014

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Fascin1 promotes cell migration of mature dendritic cells.
Yoshihiko Yamakita, Fumio Matsumura, Michael W Lipscomb, Po-chien Chou, Guy Werlen

J Immunol· March 2011

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The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
Sandra Pastorino, Hemamalini Renganathan, Maisel J Caliva, Erin L Filbert, John Opoku-Ansah, Guy Werlen

FASEB J· August 2010

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A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction.
Raedun L Clarke, Sandra Thiemann, Yosef Refaeli, Guy Werlen, Terry A Potter

Eur J Immunol· June 2009

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Thymocyte-fate decisions: bittersweet new flavor.
Guy Werlen

Blood· July 2008

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling.
Mark A Daniels, Emma Teixeiro, Jason Gill, Barbara Hausmann, Dominique Roubaty, Guy Werlen

Nature· December 2006

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Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.
Matthew Lovatt, Andrew Filby, Valentino Parravicini, Guy Werlen, Ed Palmer

Mol Cell Biol· November 2006

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Signaling life and death in the thymus: timing is everything.
Guy Werlen, Barbara Hausmann, Dieter Naeher, Ed Palmer

Science· March 2003

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The T-cell receptor signalosome: a dynamic structure with expanding complexity.
Guy Werlen, Ed Palmer

Curr Opin Immunol· June 2002

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