Publications by authors named "Haibing Zhou"

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The novel SIRT2-targeted PROTAC degraders as the efficient agents for the treatment of ovarian cancer.
Dandan Wang, Yihe Wu, Yijin Zhao, Xiaoyu Ma, Jiahao Shi, Hai-Bing Zhou

Eur J Med Chem· January 2026

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Targeted degradation of estrogen receptor β to overcome Osimertinib resistance in non-small cell lung carcinoma.
Yunchong Meng, Xiaofei Deng, Baohua Xie, Wei Lin, Na Wang, Hai-Bing Zhou

Bioorg Chem· December 2025

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Kill Two Birds with One Stone: An Efficient and Potent AR CBS-Targeted Degrader Reverses Breast Cancer Resistance via Concurrent AR Degradation and ERα Transcriptional Suppression.
Yihe Wu, Baohua Xie, Jinsen Liang, Dongmei Wei, Yubo Wang, Hai-Bing Zhou

J Med Chem· November 2025

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KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML.
Junhui Lv, Zhinang Yin, Conghui Li, Honglin Wen, Jian Ni, Ying Zhou, Hai-Bing Zhou

Genome Biol· August 2025

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Targeted Degradation of the Estrogen Receptor α through Unconventional Coactivator Binding Site (CBS).
Yubo Wang, Baohua Xie, Xiaofei Deng, Chune Dong, Hai-Bing Zhou

J Med Chem· July 2025

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Intercepting the Downstream of the Estrogen Receptor Signaling Pathway: Discovery of a Potent and Efficient SRC-3 PROTAC Degrader for Overcoming Endocrine Resistance Breast Cancer.
Jinsen Liang, Dandan Wang, Yihe Wu, Jiahao Shi, Baohua Xie, Hai-Bing Zhou

J Med Chem· June 2025

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Discovery of ERα-targeting PROTACs with intrinsic fluorescence for precision theranostics of breast cancer.
Yihe Wu, Junhong Dai, Xiaofei Deng, Pei He, Jinsen Liang, Hai-Bing Zhou

RSC Med Chem· May 2025

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Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation.
Zemin Song, Yali Cui, Lilan Xin, Ruijing Xiao, Jingjing Feng, Ying Zhou, Fuling Zhou, Hai-Bing Zhou

Cell Stem Cell· April 2025

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An estrogen receptor β-targeted near-infrared probe for theranostic imaging of prostate cancer.
Junhong Dai, Yihe Wu, Xiaofei Deng, Hai-Bing Zhou, Chune Dong

RSC Med Chem· March 2025

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Pegylated NIR Fluorophore-Conjugated OBHSA Prodrug for ERα-Targeted Theranostics with Enhanced Imaging and Long-Term Retention.
Xiaohua Wang, Xiaofei Deng, Lilan Xin, Chune Dong, Guoyuan Hu, Hai-Bing Zhou

Molecules· January 2025

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Target protein identification in live cells and organisms with a non-diffusive proximity tagging system.
Yingjie Sun, Changheng Li, Xiaofei Deng, Wenjie Li, Xiaoyi Deng, Hai-Bing Zhou

Elife· December 2024

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OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Rong Shen, Jiawei Zhou, Lilan Xin, Hai-Bing Zhou, Jian Huang

J Steroid Biochem Mol Biol· November 2024

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Corrigendum to "Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer" [Eur. J. Med. Chem. 253 (2023) 115328].
Lilan Xin, Jian Min, Hebing Hu, Yuanyuan Li, Chuanqian Du, Hai-Bing Zhou

Eur J Med Chem· October 2024

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Novel Hsp90-Targeting PROTACs: Enhanced synergy with cisplatin in combination therapy of cervical cancer.
Jinsen Liang, Dandan Wang, Yijin Zhao, Yihe Wu, Xuelian Liu, Hai-Bing Zhou

Eur J Med Chem· September 2024

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FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia.
Yuxin Tan, Lilan Xin, Qian Wang, Rong Xu, Xiqin Tong, Haibing Zhou, Fuling Zhou

Cancer Lett· June 2024

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Novel Acyl Thiourea-Based Hydrophobic Tagging Degraders Exert Potent Anti-Influenza Activity through Two Distinct Endonuclease Polymerase Acidic-Targeted Degradation Pathways.
Xiaoyu Ma, Xueyun Wang, Feifei Chen, Wenting Zou, Junrui Ren, Hai-Bing Zhou

J Med Chem· June 2024

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Discovery of Novel ERα and Aromatase Dual-Targeting PROTAC Degraders to Overcome Endocrine-Resistant Breast Cancer.
Lilan Xin, Chao Wang, Yan Cheng, Hongli Wang, Xinyi Guo, Hai-Bing Zhou

J Med Chem· June 2024

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Fluorescence theranostic PROTACs for real-time visualization of ERα degradation.
Xiaohua Wang, Lilan Xin, Xiaofei Deng, Chune Dong, Guoyuan Hu, Hai-Bing Zhou

Eur J Med Chem· March 2024

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Novel estrogen receptor β/histone deacetylase dual-targeted near-infrared fluorescent probes as theranostic agents for imaging and treatment of prostate cancer.
Pei He, Huiguang Yu, Xiaofei Deng, Lilan Xin, Bin Xu, Hai-Bing Zhou

Eur J Med Chem· March 2024

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A Drug Molecule-Modified Graphene Field-Effect Transistor Nanosensor for Rapid, Label-Free, and Ultrasensitive Detection of Estrogen Receptor α Protein.
Pinghong Ming, Jiahao Li, Lu Yang, Yi Yu, Lina Tang, Haibing Zhou

Anal Chem· February 2024

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Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer.
Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, Hebing Hu, Hai-Bing Zhou

Acta Pharm Sin B· December 2023

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Rational design and optimization of acylthioureas as novel potent influenza virus non-nucleoside polymerase inhibitors.
Xinjin Liu, Zhichao Xu, Jinsen Liang, Ting Xu, Wenting Zou, Hai-Bing Zhou

Eur J Med Chem· November 2023

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Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer.
Xiangping Deng, Xiaofei Deng, Wentao Ning, Lilan Xin, Qiuzi Li, Hai-Bing Zhou

J Med Chem· August 2023

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Antiviral PROTACs: Opportunity borne with challenge.
Jinsen Liang, Yihe Wu, Ke Lan, Chune Dong, Shuwen Wu, Hai-Bing Zhou

Cell Insight· June 2023

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CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.
Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Hai-Bing Zhou

Sci Adv· May 2023

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