Publications by authors named "Haigen Fu"

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Biocatalytic Atroposelective Synthesis of Axially Chiral Styrenes via Dynamic Kinetic Resolution.
Pengpeng Zhang, Zhuangfei Tian, Congcong Li, Runze Meng, Bowen Zhang, Haigen Fu

Angew Chem Int Ed Engl· December 2025

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Asymmetric Conjugate Hydrocyanation of α,β-Unsaturated Aldehydes Catalyzed by Engineered 2-Deoxy-D-ribose-5-phosphate Aldolase.
Hangyu Zhou, Peter Fodran, Haigen Fu, Gerrit J Poelarends

Chemistry· December 2025

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Targeting HDAC8 sensitizes tyrosine kinase inhibitors in the elimination of B-cell acute lymphoblastic leukemia cells through degradation of HIF-1α.
Guilin Xu, Feng Wang, Ming Chen, Wenhui Gao, Ying Liu, Haigen Fu

Leukemia· November 2025

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Engineering an Imine Reductase for Enantioselective Synthesis of Atropisomeric Amides.
Zhouchang Yao, Runze Meng, Zitian Zhou, Luyao Yu, Zhiyun Wu, Haigen Fu

J Am Chem Soc· November 2025

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Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins.
Huimin Jiang, Yongjian Wang, Churan Wang, Lu Yang, Shujuan Wang, Haigen Fu

Cell Death Dis· August 2025

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Imine Reductase-Catalyzed Remote Stereocontrol for Enantiodivergent Synthesis of Cyclohexylidene-Based Axially Chiral Amines.
Keting Li, Zhen Liu, Bin Wang, Ling Huang, Luyao Yu, Haigen Fu

Angew Chem Int Ed Engl· July 2025

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Atroposelective Synthesis of Axial Biaryls by Dynamic Kinetic Resolution Using Engineered Imine Reductases.
Xinyue Hao, Zhuangfei Tian, Zhouchang Yao, Tienan Zang, Shucheng Song, Haigen Fu

Angew Chem Int Ed Engl· October 2024

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From Ground-State to Excited-State Activation Modes: Flavin-Dependent "Ene"-Reductases Catalyzed Non-natural Radical Reactions.
Haigen Fu, Todd K Hyster

Acc Chem Res· May 2024

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Tailored photoenzymatic systems for selective reduction of aliphatic and aromatic nitro compounds fueled by light.
Alejandro Prats Luján, Mohammad Faizan Bhat, Sona Tsaturyan, Ronald van Merkerk, Haigen Fu

Nat Commun· September 2023

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Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs.
Zhiwen Li, Zhihao Guo, Xi Lu, Xican Ma, Xiukun Wang, Haigen Fu, Xuefu You

Acta Pharm Sin B· July 2023

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Photobiocatalytic Strategies for Organic Synthesis.
Megan A Emmanuel, Sophie G Bender, Catherine Bilodeau, Jose M Carceller, Jacob S DeHovitz, Haigen Fu

Chem Rev· May 2023

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Asymmetric -Alkylation of Nitroalkanes Enzymatic Photoredox Catalysis.
Haigen Fu, Tianzhang Qiao, Jose M Carceller, Samantha N MacMillan, Todd K Hyster

J Am Chem Soc· January 2023

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An asymmetric sp-sp cross-electrophile coupling using 'ene'-reductases.
Haigen Fu, Jingzhe Cao, Tianzhang Qiao, Yuyin Qi, Simon J Charnock

Nature· October 2022

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Activation modes in biocatalytic radical cyclization reactions.
Yuxuan Ye, Haigen Fu, Todd K Hyster

J Ind Microbiol Biotechnol· June 2021

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Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions.
Haigen Fu, Heather Lam, Megan A Emmanuel, Ji Hye Kim, Braddock A Sandoval

J Am Chem Soc· June 2021

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Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue.
Valentina Arkhipova, Haigen Fu, Mark W H Hoorens, Gianluca Trinco, Lucien N Lameijer

J Am Chem Soc· January 2021

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Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1.
Kamaleddin H M E Tehrani, Haigen Fu, Nora C Brüchle, Vida Mashayekhi, Alejandro Prats Luján

Chem Commun (Camb)· March 2020

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Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners.
Jielin Zhang, Eleonora Grandi, Haigen Fu, Thangavelu Saravanan, Laura Bothof

Angew Chem Int Ed Engl· January 2020

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Synthesis and antibacterial evaluation against resistant Gram-negative bacteria of monobactams bearing various substituents on oxime residue.
Zhi-Wen Li, Xi Lu, Yan-Xiang Wang, Xin-Xin Hu, Hai-Gen Fu, Xue-Fu You

Bioorg Chem· January 2020

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SLC1A3 contributes to L-asparaginase resistance in solid tumors.
Jianhui Sun, Remco Nagel, Esther A Zaal, Alejandro Piñeiro Ugalde, Ruiqi Han, Haigen Fu

EMBO J· October 2019

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Synthesis and Biological Evaluation of Quinoline Derivatives as a Novel Class of Broad-Spectrum Antibacterial Agents.
Hai-Gen Fu, Zhi-Wen Li, Xin-Xin Hu, Shu-Yi Si, Xue-Fu You

Molecules· February 2019

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Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors.
Haigen Fu, Jielin Zhang, Pieter G Tepper, Lennart Bunch, Anders A Jensen

J Med Chem· September 2018

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Rapid chemoenzymatic route to glutamate transporter inhibitor l-TFB-TBOA and related amino acids.
Haigen Fu, Sabry H H Younes, Mohammad Saifuddin, Pieter G Tepper, Jielin Zhang

Org Biomol Chem· March 2017

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Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria.
Hai-Gen Fu, Xin-Xin Hu, Cong-Ran Li, Ying-Hong Li, Yan-Xiang Wang, Xue-Fu You

Eur J Med Chem· March 2016

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Synthesis and biological evaluation of sophoridinol derivatives as a novel family of potential anticancer agents.
Chongwen Bi, Caixia Zhang, Yinghong Li, Sheng Tang, Shenggang Wang, Haigen Fu

ACS Med Chem Lett· November 2014

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