Publications by authors named "Hairuo Peng"

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Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity.
Tricia L May-Dracka, Robert Arduini, Andrea Bertolotti-Ciarlet, Govinda Bhisetti, Margot Brickelmaier, Hairuo Peng

Bioorg Med Chem Lett· June 2018

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BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
Robert H Scannevin, Sowmya Chollate, Melanie S Brennan, Pamela A Snodgrass-Belt, Hairuo Peng

Neuropharmacology· April 2016

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Acceleration of Petasis reactions of salicylaldehyde derivatives with molecular sieves.
Xianglin Shi, Dominique Hebrault, Michael Humora, William F Kiesman, Hairuo Peng

J Org Chem· January 2012

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Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Zhili Xin, Hairuo Peng, Andrew Zhang, Tina Talreja, Gnanasambandam Kumaravel

Bioorg Med Chem Lett· December 2011

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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
Hairuo Peng, Tina Talreja, Zhili Xin, J Hernan Cuervo, Gnanasambandam Kumaravel

ACS Med Chem Lett· October 2011

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Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.
Aslamuzzaman Kazi, Adam Carie, Michelle A Blaskovich, Cynthia Bucher, Van Thai, Hairuo Peng

Mol Cell Biol· April 2009

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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
Samuel C Falsetti, De-an Wang, Hairuo Peng, Dora Carrico, Adrienne D Cox

Mol Cell Biol· November 2007

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Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.
Hairuo Peng, Dora Carrico, Van Thai, Michelle Blaskovich, Cynthia Bucher

Org Biomol Chem· May 2006

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Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.
Hairuo Peng, Gnanasambandam Kumaravel, Gang Yao, Li Sha, Joy Wang

J Med Chem· December 2004

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Synthesis and MEK1 inhibitory activities of imido-substituted 2-chloro-1,4-naphthoquinones.
Oladapo Bakare, Curtis L Ashendel, Hairuo Peng, Leon H Zalkow, Edward M Burgess

Bioorg Med Chem· July 2003

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Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases.
Hairuo Peng, Doeg-Il Kim, Jann N Sarkaria, Yong-Seo Cho, Robert T Abraham

Bioorg Med Chem· January 2002

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