Publications by authors named "Hal Hoffman"

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Interleukin-18 in obesity and obesity-related metabolic diseases.
Christian Stoess, Janset Onyuru, Phillipp Hartmann, Hal M Hoffman, Lori Broderick

Nat Rev Endocrinol· January 2026

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Dual dysregulation of TNF/interferon signaling and classical monocytes are implicated in Reactive Infectious Mucocutaneous Eruptions.
Zhehao Tan, Gio Wu, Daniela Salgado Figueroa, Paramita Dutta, Zachary Jaeger, Hal M Hoffman

JCI Insight· November 2025

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Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.
Roni Klein, Janset Onyuru, Jessica L Centa, Estela M Viera, Christopher D Putnam, Hal M Hoffman

Nucleic Acids Res· October 2025

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Differential Diagnosis of Chronic Spontaneous Urticaria.
Dimitra Gialama, Hanna Bonnekoh, Nikolai Dario Rothermel, Reid Oldenburg, David A Khan, Hal M Hoffman

J Allergy Clin Immunol Pract· September 2025

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Development of a Mouse Model of Coccidioidomycosis Using an Inhalation Exposure System.
Jonathan Rodrigo Erlich, Priscila Rodriguez, Ka Pui Sharon Yau, Matthew Tate, Aaron F Carlin, Hal M Hoffman

J Fungi (Basel)· August 2025

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Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce T differentiation.
Hongxu Xian, Kosuke Watari, Masafumi Ohira, Jonathan S Brito, Peng He, Hal M Hoffman

Nat Immunol· July 2025

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TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950.
Angela Lackner, Lemuel Leonidas, Alijah Macapagal, Hannah Lee, Huilin Xu, Hal M Hoffman

bioRxiv· June 2025

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Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation.
Roni Klein, Janset Onyuru, Jessica L Centa, Estela M Viera, Fox J Duelli, Hal M Hoffman

bioRxiv· May 2025

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Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.
Chenyang Guan, Seungjin Ryu, Mingze Dong, Yun-Hee Youm, Subhasis Mohanty, Hal M Hoffman

bioRxiv· May 2025

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The human milk oligosaccharide 3'sialyllactose reduces low-grade inflammation and atherosclerosis development in mice.
Ariane R Pessentheiner, Nathanael J Spann, Chloe A Autran, Tae Gyu Oh, Kaare V Grunddal, Hal M Hoffman

JCI Insight· November 2024

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Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells.
Juan Yu, Elsa Meneses-Salas, Jennifer L Johnson, Susanna Manenti, Mouad Ait Kbaich, Hal Hoffman

Cell Rep· August 2024

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Publisher Correction: IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting.
Lori Broderick, Hal M Hoffman

Nat Rev Rheumatol· July 2024

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The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity.
Christopher D Putnam, Lori Broderick, Hal M Hoffman

Immunol Rev· March 2024

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Cell Death in Liver Disease and Liver Surgery.
Christian Stoess, Yeon-Kyung Choi, Janset Onyuru, Helmut Friess, Hal M Hoffman

Biomedicines· March 2024

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BRP39 Regulates Neutrophil Recruitment in NLRP3 Inflammasome-Induced Liver Inflammation.
Lin Kui, Andrea D Kim, Janset Onyuru, Hal M Hoffman, Ariel E Feldstein

Cell Mol Gastroenterol Hepatol· February 2024

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NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis.
Benedikt Kaufmann, Aleksandra Leszczynska, Agustina Reca, Laela M Booshehri, Janset Onyuru, Hal M Hoffman

EMBO Rep· January 2024

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NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils.
Yanfang Peipei Zhu, Mary Speir, ZheHao Tan, Jamie Casey Lee, Cameron J Nowell, Hal M Hoffman

Sci Adv· December 2023

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Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Hal M Hoffman

Sci Rep· November 2023

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Cold Urticaria Syndromes: Diagnosis and Management.
Vanessa L Diaz, K Bates Gribbons, Katayoun Yazdi-Nejad, Jasmin Kuemmerle-Deschner, Alan A Wanderer, Hal M Hoffman

J Allergy Clin Immunol Pract· August 2023

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Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
Davide Povero, Milos Lazic, Christopher McBride, Geza Ambrus-Aikelin, Ryan Stansfield, Hal M Hoffman

J Pharmacol Exp Ther· August 2023

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Endothelial Cell Response in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children.
Jihoon Kim, Chisato Shimizu, Ming He, Hao Wang, Hal M Hoffman

Int J Mol Sci· August 2023

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JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Hal M Hoffman

Sci Rep· August 2023

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Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice.
Benedikt Kaufmann, Marta de Los Reyes Jiménez, Laela M Booshehri, Janset Onyuru, Aleksandra Leszczynska, Hal M Hoffman

J Immunol· July 2023

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Author Correction: Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation.
Angela Cabral, Julia Elise Cabral, Angelina Wang, Yiyang Zhang, Hailin Liang, Hal M Hoffman

Commun Biol· June 2023

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Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders.
Mariasilvia Colantuoni, Raisa Jofra Hernandez, Emanuela Pettinato, Luca Basso-Ricci, Laura Magnani, Hal M Hoffman

Sci Transl Med· May 2023

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