Publications by authors named "Hamutal Engel"

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Targeting phenylalanine assemblies as a prospective disease-modifying therapy for phenylketonuria.
Shira Shaham-Niv, Assaf Ezra, Dor Zaguri, Stav Roni Shotan, Elvira Haimov, Hamutal Engel

Biophys Chem· May 2024

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Allosteric inhibitors targeting the calmodulin-PIP2 interface of SK4 K channels for atrial fibrillation treatment.
Shira Burg, Shir Shapiro, Asher Peretz, Elvira Haimov, Boris Redko, Hamutal Engel

Proc Natl Acad Sci U S A· August 2022

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The contribution of individual residues of an aggregative hexapeptide derived from the human γD-crystallin to its amyloidogenicity.
Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Luba Simhaev, Ashim Paul, Hamutal Engel

Int J Biol Macromol· March 2022

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Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism.
Or Kakhlon, Hilla Vaknin, Kumudesh Mishra, Jeevitha D'Souza, Monzer Marisat, Hamutal Engel

EMBO Mol Med· October 2021

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Chemical Chaperones Modulate the Formation of Metabolite Assemblies.
Hanaa Adsi, Shon A Levkovich, Elvira Haimov, Topaz Kreiser, Massimiliano Meli, Hamutal Engel

Int J Mol Sci· August 2021

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Inhibition of tau amyloid formation and disruption of its preformed fibrils by Naphthoquinone-Dopamine hybrid.
Ashim Paul, Guru KrishnaKumar Viswanathan, Adi Huber, Elad Arad, Hamutal Engel

FEBS J· July 2021

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Inhibition of amyloid fibrillation of γD-crystallin model peptide by the cochineal Carmine.
Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Lia Borisover, Michael Mimouni, Hamutal Engel

Int J Biol Macromol· February 2021

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TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.
Emese Pataki, Luba Simhaev, Hamutal Engel, Adiel Cohen, Martin Kupiec

PLoS Genet· November 2020

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Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex.
Michal Lisnyansky Bar-El, Pavla Vaňková, Adva Yeheskel, Luba Simhaev, Hamutal Engel

Nat Commun· October 2020

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Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model.
Guru Krishnakumar Viswanathan, Dana Shwartz, Yelena Losev, Elad Arad, Chen Shemesh, Hamutal Engel

Cell Mol Life Sci· July 2020

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A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models.
Javier Ganz, Talya Shacham, Maria Kramer, Marina Shenkman, Hagit Eiger, Hamutal Engel

Sci Rep· April 2020

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Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics.
Sivan Louzoun Zada, Bar Ben Baruch, Luba Simhaev, Hamutal Engel, Micha Fridman

J Am Chem Soc· February 2020

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Mechanisms of Metabolite Amyloid Formation: Computational Studies for Drug Design against Metabolic Disorders.
Massimiliano Meli, Hamutal Engel, Dana Laor, Ehud Gazit, Giorgio Colombo

ACS Med Chem Lett· April 2019

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Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation.
Dana Laor, Dorin Sade, Shira Shaham-Niv, Dor Zaguri, Myra Gartner, Hamutal Engel

Nat Commun· January 2019

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Integrating in vitro and in silico approaches to evaluate the "dual functionality" of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils.
Esraa Haj, Yelena Losev, V Guru KrishnaKumar, Edward Pichinuk, Hamutal Engel

Biochim Biophys Acta Gen Subj· July 2018

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Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells.
Raphael I Benhamou, Maayan Bibi, Kfir B Steinbuch, Hamutal Engel, Maayan Levin

ACS Chem Biol· July 2017

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Hybrid Quantum and Classical Simulations of the Formate Dehydrogenase Catalyzed Hydride Transfer Reaction on an Accurate Semiempirical Potential Energy Surface.
Alexandra Vardi-Kilshtain, Dan Thomas Major, Amnon Kohen, Hamutal Engel, Dvir Doron

J Chem Theory Comput· November 2012

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Momentum Distribution as a Fingerprint of Quantum Delocalization in Enzymatic Reactions: Open-Chain Path-Integral Simulations of Model Systems and the Hydride Transfer in Dihydrofolate Reductase.
Hamutal Engel, Dvir Doron, Amnon Kohen, Dan Thomas Major

J Chem Theory Comput· April 2012

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Path-Integral Calculations of Nuclear Quantum Effects in Model Systems, Small Molecules, and Enzymes via Gradient-Based Forward Corrector Algorithms.
Asaf Azuri, Hamutal Engel, Dvir Doron, Dan Thomas Major

J Chem Theory Comput· May 2011

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Global uniform semiclassical approximation for Clebsch-Gordan coefficients.
Hamutal Engel, Kenneth G Kay

J Chem Phys· March 2008

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