Publications by authors named "Handule Lee"

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Integrated in silico and in vitro assessment of estrogen and androgen receptor activity of 10 selected PFAS within an Integrated Approach to Testing and Assessment (IATA).
Darlene Mae D Ortiz, Handule Lee, Ngoc Minh-Hong Hoang, Hyun Jun Lee, Jinhee Choi

Toxicol Appl Pharmacol· January 2026

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Comprehensive estrogenicity assessment of 4-methylbenzophenone via in vivo, in vitro, and in silico approaches within an integrated testing strategy framework.
Darlene Mae D Ortiz, Ngoc Minh-Hong Hoang, Handule Lee, Kwangsik Park

Toxicol Lett· December 2025

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Diethyl-hexyl-cyclohexane (Eco-DEHCH) is a safer phthalate alternative that does not elicit neuroendocrine disrupting effects.
Jiyun Kang, Cong Minh Tran, Handule Lee, Seong Soon Kim, Sung-Hee Cho

J Hazard Mater· July 2025

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Repeated dose toxicity of 4-methylbenzophenone: hepatotoxic and nephrotoxic effects in female Sprague-Dawley rats.
Darlene Mae D Ortiz, Ngoc Minh-Hong Hoang, Handule Lee, Juyoung Park, Kwangsik Park

Toxicol Res· July 2025

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Application of the Integrated Approach to Testing and Assessment (IATA) for evaluating endocrine disruption potential of selected pyrethroids by H295R steroidogenesis and ER/AR transcriptional activation.
Darlene Mae D Ortiz, Handule Lee, Kwangsik Park

Chemosphere· March 2025

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Estrogen receptor/androgen receptor transcriptional activation of benzophenone derivatives and integrated approaches to testing and assessment (IATA) for estrogenic effects.
Handule Lee, Juyoung Park, Darlene M Ortiz, Kwangsik Park

Toxicol In Vitro· October 2024

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Integrated Assessment for the Estrogenic Effects of Pyrethroid Compounds: Defining the Molecular Initiating Events and Key Events for the Adverse Outcome Pathway.
Darlene Mae D Ortiz, Juyoung Park, Handule Lee, Kwangsik Park

Toxics· March 2024

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Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation.
Handule Lee, Juyoung Park, Kwangsik Park

Toxics· December 2023

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Potency classification of isothiazolinone compounds based on defined approaches of skin sensitization in OECD GL 497.
Hyejin Kim, Juyoung Park, Handule Lee, Jinseon Son, Yeonjung Park, Sang Hee Lee

Environ Anal Health Toxicol· December 2023

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The mixture effect of propyl paraben and bisphenol A on the uterotrophic response in the ovariectomized rats after oral administration.
Juyoung Park, Handule Lee, Dal-Woong Choi, Kwangsik Park

Environ Anal Health Toxicol· March 2023

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Effects of consumer products chemicals ingredients and their mixtures on the estrogen receptor/androgen receptor transcriptional activation.
Handule Lee, Juyoung Park, Kwangsik Park

Chemosphere· September 2022

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Assessment of agonistic and antagonistic properties of humidifier disinfectants to the estrogenic and androgenic receptors by transactivation assay.
Handule Lee, Juyoung Park, Kwangsik Park

Toxicol Res· January 2022

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Gastrointestinal tract and skin permeability of chemicals in consumer products using parallel artificial membrane permeability assay (PAMPA).
Juyoung Park, Handule Lee, Kwangsik Park

Environ Anal Health Toxicol· September 2021

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Fibrosis as a result of polyhexamethylene guanide exposure in cultured Statens Seruminstitut Rabbit Cornea (SIRC) cells.
Handule Lee, Juyoung Park, Kwangsik Park

Environ Anal Health Toxicol· June 2021

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Acute toxicity of benzalkonium chloride in Balb/c mice following intratracheal instillation and oral administration.
Handule Lee, Kwangsik Park

Environ Anal Health Toxicol· September 2019

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Cytotoxicity of Zinc Oxide Nanoparticles in Cultured Statens Seruminstitut Rabbit Cornea Cells.
Handule Lee, Kwangsik Park

Toxicol Res· July 2019

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Eye irritation tests of polyhexamethylene guanidine phosphate (PHMG) and chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a tissue model of reconstructed human cornea-like epithelium.
Juyoung Park, Handule Lee, Kwangsik Park

Environ Health Toxicol· June 2019

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Toxicity and tissue distribution of cerium oxide nanoparticles in rats by two different routes: single intravenous injection and single oral administration.
Kwangsik Park, Juyoung Park, Handule Lee, Jonghye Choi, Wook-Joon Yu, Jinsoo Lee

Arch Pharm Res· November 2018

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Mixture Toxicity of Methylisothiazolinone and Propylene Glycol at a Maximum Concentration for Personal Care Products.
Juyoung Park, Handule Lee, Kwangsik Park

Toxicol Res· October 2018

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Developmental toxicity of intravenously injected zinc oxide nanoparticles in rats.
Jinsoo Lee, Wook-Joon Yu, Jeongah Song, Changhyun Sung, Eun Ju Jeong, Handule Lee

Arch Pharm Res· December 2016

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Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm.
Hyejin Kim, Jonghye Choi, Handule Lee, Juyoung Park, Byung-Il Yoon

Toxicol Res· October 2016

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