Publications by authors named "Hangchen Hu"

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Structure-Based Development of Ultra-Broad-Spectrum 3C-Like Protease Inhibitors.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Hangchen Hu, Yechun Xu

Adv Sci (Weinh)· December 2025

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De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS.
Wenfeng Zhao, Guofeng Chen, Jian He, Xiaofang Shen, Muya Xiong, Huixia Dou, Hangchen Hu, Yechun Xu

Nat Commun· June 2025

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Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro.
Haixia Su, Guofeng Chen, Hang Xie, Wanchen Li, Muya Xiong, Hangchen Hu, Yechun Xu

Nat Commun· May 2025

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Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors.
Xudong Wang, Liwei Xiong, Ying Zhu, Sixiu Liu, Wenfeng Zhao, Yechun Xu, Hangchen Hu

J Am Chem Soc· December 2024

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Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations.
Muya Xiong, Tianqing Nie, Zhewen Li, Meiyi Hu, Haixia Su, Hangchen Hu, Yechun Xu

J Chem Inf Model· December 2024

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Chemical Space Profiling of SARS-CoV-2 PL Using DNA-Encoded Focused Libraries.
Xudong Wang, Ying Zhu, Qingyi Zhao, Weiwei Lu, Yechun Xu, Hangchen Hu

ACS Med Chem Lett· April 2024

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Discovery, SAR Study of GST Inhibitors from a Novel Quinazolin-4(1)-one Focused DNA-Encoded Library.
Xin Wen, Minmin Zhang, Zhiqiang Duan, Yanrui Suo, Weiwei Lu, Linghua Meng, Hangchen Hu, Jian Zhu

J Med Chem· August 2023

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Unraveling the catalytic mechanism of SARS-CoV-2 papain-like protease with allosteric modulation of C270 mutation using multiscale computational approaches.
Qiang Shao, Muya Xiong, Jiameng Li, Hangchen Hu, Haixia Su, Yechun Xu

Chem Sci· May 2023

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Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease.
Qian Wang, Guofeng Chen, Jian He, Jiameng Li, Muya Xiong, Hangchen Hu, Yechun Xu

Int J Mol Sci· May 2023

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Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease.
Hangchen Hu, Qian Wang, Haixia Su, Qiang Shao, Wenfeng Zhao, Yechun Xu

Angew Chem Int Ed Engl· December 2022

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Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease.
Yanchao Xiong, Fei Cheng, Junyi Zhang, Haixia Su, Hangchen Hu, Yechun Xu

Bioorg Chem· November 2022

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Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients.
Hai-Xia Su, Sheng Yao, Wen-Feng Zhao, Min-Jun Li, Jia Liu, Hang-Chen Hu, Hua-Liang Jiang, Ye-Chun Xu

Acta Pharmacol Sin· September 2020

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Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach.
Fubao Huang, Hangchen Hu, Kai Wang, Chengyuan Peng, Wenwei Xu, Hu Zhou, Ruimin Huang, Jianhua Shen, Yechun Xu

J Med Chem· July 2020

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Structure-Based Survey of the Binding Modes of BACE1 Inhibitors.
Hangchen Hu, Zhaoqiang Chen, Xiang Xu, Yechun Xu

ACS Chem Neurosci· February 2019

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