Publications by authors named "Harold Sims"

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High-fat diet activates liver iPLAγ generating eicosanoids that mediate metabolic stress.
Sung Ho Moon, Beverly Gibson Dilthey, Xinping Liu, Shaoping Guan, Harold F Sims

J Lipid Res· July 2024

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Genetic deletion of skeletal muscle iPLAγ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism.
Sung Ho Moon, Beverly Gibson Dilthey, Shaoping Guan, Harold F Sims, Sara K Pittman

iScience· June 2023

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A functional role for eicosanoid-lysophospholipids in activating monocyte signaling.
Gao-Yuan Liu, Sung Ho Moon, Christopher M Jenkins, Harold F Sims, Shaoping Guan

J Biol Chem· August 2020

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12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLAγ knockout.
Xinping Liu, Harold F Sims, Christopher M Jenkins, Shaoping Guan, Beverly G Dilthey

J Biol Chem· April 2020

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Synthesis of oxidized phospholipids by -1 acyltransferase using 2-15-HETE lysophospholipids.
Gao-Yuan Liu, Sung Ho Moon, Christopher M Jenkins, Harold F Sims, Shaoping Guan

J Biol Chem· June 2019

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The phospholipase iPLAγ is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.
Gao-Yuan Liu, Sung Ho Moon, Christopher M Jenkins, Maoyin Li, Harold F Sims

J Biol Chem· June 2017

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Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways.
Xinping Liu, Sung Ho Moon, Christopher M Jenkins, Harold F Sims, Richard W Gross

Cell Chem Biol· October 2016

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Cardiac Myocyte-specific Knock-out of Calcium-independent Phospholipase A2γ (iPLA2γ) Decreases Oxidized Fatty Acids during Ischemia/Reperfusion and Reduces Infarct Size.
Sung Ho Moon, David J Mancuso, Harold F Sims, Xinping Liu, Annie L Nguyen

J Biol Chem· September 2016

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Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation.
Xinping Liu, Sung Ho Moon, David J Mancuso, Christopher M Jenkins, Shaoping Guan, Harold F Sims

Anal Biochem· November 2013

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Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome.
Michael A Kiebish, Kui Yang, Xinping Liu, David J Mancuso, Shaoping Guan, Harold F Sims

J Lipid Res· May 2013

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Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release.
Sung Ho Moon, Christopher M Jenkins, Michael A Kiebish, Harold F Sims, David J Mancuso

J Biol Chem· August 2012

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Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.
Michael A Kiebish, Kui Yang, Harold F Sims, Christopher M Jenkins, Xinping Liu

J Biol Chem· July 2012

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Activation of group VI phospholipase A2 isoforms in cardiac endothelial cells.
Janhavi Sharma, John Turk, David J Mancuso, Harold F Sims, Richard W Gross

Am J Physiol Cell Physiol· April 2011

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Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism.
Christopher M Jenkins, Jingyue Yang, Harold F Sims, Richard W Gross

J Biol Chem· April 2011

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Genetic ablation of calcium-independent phospholipase A2gamma prevents obesity and insulin resistance during high fat feeding by mitochondrial uncoupling and increased adipocyte fatty acid oxidation.
David J Mancuso, Harold F Sims, Kui Yang, Michael A Kiebish, Xiong Su

J Biol Chem· November 2010

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Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.
David J Mancuso, Paul Kotzbauer, David F Wozniak, Harold F Sims, Christopher M Jenkins

J Biol Chem· December 2009

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Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.
David J Mancuso, Harold F Sims, Xianlin Han, Christopher M Jenkins, Shao Ping Guan

J Biol Chem· November 2007

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Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.
David J Mancuso, Xianlin Han, Christopher M Jenkins, John J Lehman, Nandakumar Sambandam, Harold F Sims

J Biol Chem· March 2007

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Abnormal mitochondrial bioenergetics and heart rate dysfunction in mice lacking very-long-chain acyl-CoA dehydrogenase.
Vernat J Exil, Carla D Gardner, Jeffrey N Rottman, Harold Sims, Beatrijs Bartelds

Am J Physiol Heart Circ Physiol· March 2006

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The highly selective production of 2-arachidonoyl lysophosphatidylcholine catalyzed by purified calcium-independent phospholipase A2gamma: identification of a novel enzymatic mediator for the generation of a key branch point intermediate in eicosanoid signaling.
Wei Yan, Christopher M Jenkins, Xianlin Han, David J Mancuso, Harold F Sims

J Biol Chem· July 2005

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Complex transcriptional and translational regulation of iPLAgamma resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization.
David J Mancuso, Christopher M Jenkins, Harold F Sims, Joshua M Cohen, Jingyue Yang

Eur J Biochem· December 2004

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Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.
Christopher M Jenkins, David J Mancuso, Wei Yan, Harold F Sims, Beverly Gibson

J Biol Chem· November 2004

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Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOF-TOF analysis.
Christopher M Jenkins, Xianlin Han, Jingyue Yang, David J Mancuso, Harold F Sims

Biochemistry· October 2003

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Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice.
Vernat J Exil, Richard L Roberts, Harold Sims, Jacquelin E McLaughlin, Robert A Malkin

Circ Res· September 2003

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