Publications by authors named "Harold Weller"

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Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay.
Xianmei Cai, Shivani Patel, Chunli Huang, Anthony Paiva, Yongnian Sun, Harold Weller

Xenobiotica· July 2022

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Microscale purification in support of high-throughput medicinal chemistry.
Chandan L Barhate, Andrew F Donnell, Merrill Davies, Ling Li, Yong Zhang, Harold N Weller

Chem Commun (Camb)· October 2021

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Acoustic Ejection/Full-Scan Mass Spectrometry Analysis for High-Throughput Compound Quality Control.
Jun Zhang, Yong Zhang, Chang Liu, Tom Covey, Julia Nielsen, Harold Weller

SLAS Technol· April 2021

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Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging.
Wilson Z Shou, Samuel W Gerritz, David Harden, R Michael Lawrence, Peter Chase, Harold N Weller

SLAS Discov· February 2021

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Enabling direct and definitive free fraction determination for highly-bound compounds in protein binding assay.
Jun Zhang, Gabriela Pikul, John Horch, Daniel Konovalov, Shu Li, Harold Weller

J Pharm Biomed Anal· February 2021

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Ultrahigh-Throughput and Chromatography-Free Bioanalysis of Polar Analytes with Acoustic Ejection Mass Spectrometry.
Andrew Wagner, Jun Zhang, Chang Liu, Thomas R Covey, Timothy V Olah, Harold Bud N Weller

Anal Chem· October 2020

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Addition of Optimized Bovine Serum Albumin Level in a High-Throughput Caco-2 Assay Enabled Accurate Permeability Assessment for Lipophilic Compounds.
Xianmei Cai, Shilpa Madari, Aaron Walker, Anthony Paiva, Ying Li, Harold Weller

SLAS Discov· August 2019

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Optimization of microflow LC-MS/MS and its utility in quantitative discovery bioanalysis.
Jun Zhang, Wilson Shou, Tairo Ogura, Shu Li, Harold Weller

Bioanalysis· June 2019

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HPLC biogram analysis: a powerful tool used for hit confirmation in early drug discovery.
John E Leet, James V Belcastro, Craig J Dowling, Gregory A Nemeth, Harold N Weller

J Biomol Screen· June 2015

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Development of an LC-MS/MS method for high throughput quantification of metformin uptake in transporter inhibition assays.
Marianne Vath, Lizbeth Gallagher, Wilson Shou, Harold Weller, Lisa Elkin

J Chromatogr B Analyt Technol Biomed Life Sci· September 2014

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Comparative assessment of achiral stationary phases for high throughput analysis in supercritical fluid chromatography.
Katalin Ebinger, Harold N Weller

J Chromatogr A· March 2014

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A high-speed liquid chromatography/tandem mass spectrometry platform using multiplexed multiple-injection chromatography controlled by single software and its application in discovery ADME screening.
Jun Zhang, Marianne Vath, Cheryl Ferraro, Ying Li, Keeley Murphy, Harold Weller

Rapid Commun Mass Spectrom· April 2013

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Comparison of chromatographic techniques for diastereomer separation of a diverse set of drug-like compounds.
Katalin Ebinger, Harold N Weller

J Chromatogr A· January 2013

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Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification.
Harold N Weller, David S Nirschl, James L Paulson, Steven L Hoffman, William H Bullock

ACS Comb Sci· September 2012

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Approach to improve compound recovery in a high-throughput Caco-2 permeability assay supported by liquid chromatography-tandem mass spectrometry.
Xianmei Cai, Aaron Walker, Charles Cheng, Anthony Paiva, Ying Li, Harold Weller

J Pharm Sci· August 2012

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Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.
Jun Zhang, Jennifer Maloney, Dieter M Drexler, Xianmei Cai, Jeremy Stewart, Harold Weller

Bioanalysis· March 2012

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Evaluation of a new preparative supercritical fluid chromatography system for compound library purification: the TharSFC SFC-MS Prep-100 system.
Katalin Ebinger, Harold N Weller, Jeffrey Kiplinger, Paul Lefebvre

J Lab Autom· June 2011

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Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen.
Andrew D Wagner, Janet M Kolb, Can C Ozbal, John J Herbst, Timothy V Olah, Harold N Weller

Rapid Commun Mass Spectrom· May 2011

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An integrated bioanalytical platform for supporting high-throughput serum protein binding screening.
Jun Zhang, Wilson Z Shou, Marianne Vath, Kasia Kieltyka, Jennifer Maloney, Harold N Weller

Rapid Commun Mass Spectrom· December 2010

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Orthogonality of SFC versus HPLC for small molecule library separation.
Harold N Weller, Katalin Ebinger, William Bullock, Kurt J Edinger, Mark A Hermsmeier

J Comb Chem· November 2010

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A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen.
Kasia Kieltyka, Jun Zhang, Shu Li, Marianne Vath, Chris Baglieri, Harold N Weller

Rapid Commun Mass Spectrom· June 2009

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Application of lean manufacturing concepts to drug discovery: rapid analogue library synthesis.
Harold N Weller, David S Nirschl, Edward W Petrillo, Michael A Poss, Charles J Andres

J Comb Chem· November 2006

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