Publications by authors named "Harshani Lawrence"

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Melanin-Driven Delayed CPD Formation Is Independent of Melanin Biosynthesis Pathway.
Vipin K Yadav, Jyoti Srivastava, Avanthika Venkatachalam, Mukund P Tantak, Nicholas J Lawrence, Harshani R Lawrence

J Invest Dermatol· September 2025

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Unc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma.
Marilena Tauro, Tao Li, Praneeth R Sudalagunta, Mark Meads, Rafael Renatino Canevarolo, Harshani R Lawrence, Nicholas N J Lawrence

Res Sq· August 2025

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Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function.
Shengyan Xiang, Kendall C Craig, Xingju Luo, Darcy L Welch, Renan B Ferreira, Harshani R Lawrence, Nicholas J Lawrence

Mol Cancer Ther· November 2024

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Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC-Alarmin Axis.
Nicole D Vincelette, Xiaoqing Yu, Andrew T Kuykendall, Jungwon Moon, Siyuan Su, Harshani R Lawrence

Blood Cancer Discov· July 2024

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CDK7 and CDK9 inhibition interferes with transcription, translation, and stemness, and induces cytotoxicity in GBM irrespective of temozolomide sensitivity.
Isha Bhutada, Fatema Khambati, Shi-Yuan Cheng, Deanna M Tiek, Derek Duckett, Harshani Lawrence

Neuro Oncol· January 2024

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Delving into the reducing effects of the GABA positive allosteric modulator, KK-92A, on alcohol-related behaviors in rats.
Paola Maccioni, Katarzyna Kaczanowska, Carla Lobina, Laura Regonini Somenzi, Valentina Bassareo, Harshani R Lawrence

Alcohol· November 2023

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Differential Chemoproteomics Reveals MARK2/3 as Cell Migration-Relevant Targets of the ALK Inhibitor Brigatinib.
Qianqian Hu, Yi Liao, Jessica Cao, Bin Fang, Sang Y Yun, Harshani R Lawrence

Chembiochem· June 2023

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Integrated proteomics identifies PARP inhibitor-induced prosurvival signaling changes as potential vulnerabilities in ovarian cancer.
Ou Deng, Sweta Dash, Thales C Nepomuceno, Bin Fang, Sang Y Yun, Harshani R Lawrence

J Biol Chem· November 2022

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TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate.
Rebecca S Hesterberg, Min Liu, Aya G Elmarsafawi, John M Koomen, Eric A Welsh, Harshani R Lawrence

Cancer Immunol Res· October 2022

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Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting.
Mithila Sawant, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Jingqin Luo, Nicholas J Lawrence, Harshani R Lawrence

Sci Transl Med· June 2022

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Deubiquitinase Vulnerabilities Identified through Activity-Based Protein Profiling in Non-Small Cell Lung Cancer.
Shikha Mahajan, Anurima Majumder, Paul A Stewart, Yian Ann Chen, Emma Adhikari, Harshani Lawrence

ACS Chem Biol· April 2022

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Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair.
Kelly Walton, Kirsti Walker, Megan Riddle, Brent H Koehn, Jordan Reff, Harshani R Lawrence, Nicholas J Lawrence

Am J Transplant· March 2022

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The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors.
Vinayak Palve, Claire E Knezevic, Daniel S Bejan, Yunting Luo, Xueli Li, Harshani R Lawrence

Cell Chem Biol· February 2022

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The Novel Positive Allosteric Modulator of the GABA Receptor, KK-92A, Suppresses Alcohol Self-Administration and Cue-Induced Reinstatement of Alcohol Seeking in Rats.
Paola Maccioni, Katarzyna Kaczanowska, Harshani Lawrence, Sang Yun, Jessica Bratzu

Front Cell Dev Biol· October 2021

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Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results.
Joseph Pidala, Kelly Walton, Hany Elmariah, Jongphil Kim, Asmita Mishra, Nicholas J Lawrence, Harshani R Lawrence

Clin Cancer Res· May 2021

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Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer.
Jeremy J McGuire, Jeremy S Frieling, Chen Hao Lo, Tao Li, Ayaz Muhammad, Harshani R Lawrence, Nicholas J Lawrence

Nat Commun· February 2021

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Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.
Ryan R Davis, Baoli Li, Sang Y Yun, Alice Chan, Pradeep Nareddy, Harshani R Lawrence, Nicholas J Lawrence

J Med Chem· February 2021

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Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes.
Rebecca S Hesterberg, Matthew S Beatty, Ying Han, Mario R Fernandez, Afua A Akuffo, Nicholas J Lawrence, Harshani R Lawrence

Blood· August 2020

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Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity.
Qingliang Li, Rezaul M Karim, Mo Cheng, Mousumi Das, Lihong Chen, Harshani R Lawrence

Oncogene· July 2020

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Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity.
Kelly Walton, Mario R Fernandez, Elizabeth M Sagatys, Jordan Reff, Jongphil Kim, Nicholas J Lawrence, Harshani R Lawrence

JCI Insight· May 2020

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Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Liwei Chen, Perry Kennedy, Harshani R Lawrence

Clin Cancer Res· October 2019

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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets.
Natalia J Sumi, Claudia Ctortecka, Qianqian Hu, Annamarie T Bryant, Bin Fang, Harshani R Lawrence

Cell Chem Biol· September 2019

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Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC.
Marwa Alhothali, Mevin Mathew, Geeta Iyer, Harshani R Lawrence, Shengyu Yang

Int J Mol Sci· May 2019

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Targeting the BRD4-HOXB13 Coregulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer.
Niveditha Nerlakanti, Jiqiang Yao, Duy T Nguyen, Ami K Patel, Alexey M Eroshkin, Harshani R Lawrence, Nicholas J Lawrence

Mol Cancer Ther· December 2018

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GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors.
Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Daniel Delitto, José Trevino, Harshani R Lawrence

Nat Commun· December 2018

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