Publications by authors named "Hasan Simsek"

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Ameliorative effects of hesperidin against iohexol-induced acute kidney injury: Modulating the levels of NF-κB/TNF-α/IL-1β, JAK2/STAT3, and Wnt3a/Dvl-2 signaling pathways.
Fatih Mutlu, Hüseyin Mutlu, Özge Kandemir, Nurhan Akaras, Hasan Şimşek

Tissue Cell· February 2026

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Protective role of catechin hydrate against aluminum chloride-induced nephrotoxicity via oxidative stress, NF-κB, Bax/Bcl-2, and PERK-CHOP pathways.
Halil Yavuz, Hasan Şimşek, Nurhan Akaras, Özge Kandemir, Sibel Çiğdem Tuncer

Eur J Pharmacol· December 2025

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Catechin hydrate alleviates tramadol-induced ovarian and uterine injury through regulation of oxidative and ER stress, apoptosis, steroidogenesis, and hormonal imbalance.
Ramazan Bülbül, Hasan Şimşek, Nurhan Akaras, Özge Kandemir, Fatih Mehmet Kandemir

Reprod Toxicol· December 2025

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Hesperidin ameliorates vancomycin-induced kidney injury via multipathway modulation: Nrf-2/HO-1, Caspase-3/Bax/Bcl-2, ATF-4, KIM-1 and improved renal tissue function.
Selman Gencer, Hasan Şimşek, Nurhan Akaras, Mustafa İleritürk, Cihan Gür

Biochem Pharmacol· October 2025

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Zingerone ameliorates sodium arsenite-induced cardiotoxicity in rats by suppressing oxidative stress and inflammation via Nrf2 /GCLM\GCLC signaling pathways.
Özge Kandemir, Fatih Mehmet Kandemir, Nurhan Akaras, Sefa Küçükler, Cihan Gür

J Trace Elem Med Biol· October 2025

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Carvacrol mitigates Mercury chloride induced neurotoxicity by regulation of NRF-2/HO-1/NF-κB expression.
Nurhan Akaras, Hasan Şimşek, Mustafa İleritürk, Sefa Küçükler, Cihan Gür

J Trace Elem Med Biol· October 2025

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Potent Ameliorative Effects of Rosmarinic Acid on Tramadol-Induced Neurotoxicity in the Brain and Hippocampus; by Suppressing Oxidative stress, Apoptosis, ER stress, and Regulating Cognitive Functions.
Onur Karaca, Hasan Şimşek, Nurhan Akaras, Cihan Gür, Mustafa İleritürk

Mol Neurobiol· August 2025

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Nephroprotective effects of hesperidin on ifosfamide-induced acute nephrotoxicity in rats: Role of NF-κB/TNF-α/ IL-1β, p53/caspase-3/Bax/Bcl-2, and ATF6/IRE1/PERK/GRP78 signaling pathways.
Özge Kandemir, Nurhan Akaras, Hasan Şimşek, Cihan Gür, Mustafa İleritürk

Arch Biochem Biophys· August 2025

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Morin Attenuates Diclofenac-Induced Hepatocellular Death Injury via Nrf2/Ho-1/NQO1, Beclin-1/LC3A/LC3B and p53/Bax/Caspase Signalling Pathways.
Nurhan Akaras, Hasan Şimşek, Cihan Gür, Sefa Küçükler, Mustafa İleritürk

J Biochem Mol Toxicol· July 2025

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Carvacrol Coadministration Ameliorates Lambda-Cyhalothrin-Induced Peripheral Neuropathy in Rats: Behavioral and Molecular Evidence.
Özge Kandemir, Mustafa İleritürk, Cihan Gür, Nurhan Akaras, Hasan Şimşek

J Biochem Mol Toxicol· July 2025

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Acute Neurochemical, Psychophysiological, and Cognitive Responses to Small-Sided Games vs. Running-Based HIIT in Young, Male Soccer Players.
Yakup Zühtü Birinci, Serkan Pancar, Yusuf Soylu, Hüseyin Topçu, Aygül Koçyiğit

Healthcare (Basel)· July 2025

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The Protective Effects of Chrysin on Acrylamide-Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats.
Selman Gencer, Nurhan Akaras, Hasan Şimşek, Cihan Gür, Mustafa İleritürk

J Biochem Mol Toxicol· June 2025

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Therapeutic potential of rosmarinic acid in tramadol-induced hepatorenal toxicity: Modulation of oxidative stress, inflammation, RAGE/NLRP3, ER stress, apoptosis, and tissue functions parameters.
Onur Karaca, Nurhan Akaras, Hasan Şimşek, Cihan Gür, Mustafa İleritürk

Food Chem Toxicol· March 2025

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Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf-2/HO-1/NQO1, Ki-67 and Wnt Signaling Pathways.
Ayşe Betül Öztürk, Nurhan Akaras, Hasan Şimşek, Fatih Mehmet Kandemir

J Biochem Mol Toxicol· January 2025

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Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways.
Hasan Şimşek, Nurhan Akaras, Cihan Gür, Sefa Küçükler, Mustafa İleritürk

Iran J Basic Med Sci· January 2025

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Carvacrol Reduces Mercuric Chloride-Induced Testicular Toxicity by Regulating Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histopathological Changes.
Hasan Şimşek, Cihan Gür, Sefa Küçükler, Mustafa İleritürk, Nurhan Akaras

Biol Trace Elem Res· October 2024

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The ameliorative effect of carvacrol on sodium arsenite-induced hepatotoxicity in rats: Possible role of Nrf2/HO-1, RAGE/NLRP3, Bax/Bcl-2/Caspase-3, and Beclin-1 pathways.
Selman Gencer, Cihan Gür, Mustafa İleritürk, Sefa Küçükler, Nurhan Akaras

J Biochem Mol Toxicol· October 2024

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The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death.
Nazım Abdülkadir Kankılıç, Hasan Şimşek, Nurhan Akaras, Cihan Gür, Sefa Küçükler

Food Chem Toxicol· August 2024

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Naringin protects against paclitaxel-induced toxicity in rat testicular tissues by regulating genes in pro-inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways.
Nazım Abdülkadir Kankılıç, Sefa Küçükler, Cihan Gür, Serkan Ali Akarsu, Nurhan Akaras

J Biochem Mol Toxicol· July 2024

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Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats.
Filiz Ozyigit, Ayse Nur Deger, Fatma Emel Kocak, Mehmet Fatih Ekici, Hasan Simsek

Acta Cir Bras· March 2024

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Protective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2/HO-1, AKT-2/FOXO1A, Bax/Bcl2/Caspase-3, and Beclin-1/LC3A/LC3B signaling pathways.
Nazım Abdülkadir Kankılıç, Hasan Şimşek, Nurhan Akaras, Cihan Gür, Mustafa İleritürk

J Biochem Mol Toxicol· February 2024

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Naringin attenuates oxaliplatin-induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model.
Mustafa Ileriturk, Duygu Ileriturk, Ozge Kandemir, Nurhan Akaras, Hasan Simsek

J Biochem Mol Toxicol· January 2024

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Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach.
Hasan Şimşek, Sefa Küçükler, Cihan Gür, Nurhan Akaras, Fatih Mehmet Kandemir

Environ Sci Pollut Res Int· September 2023

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Beneficial effects of Chrysin on Cadmium-induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO-1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways.
Hasan Şimşek, Nurhan Akaras, Cihan Gür, Sefa Küçükler, Fatih Mehmet Kandemir

Gene· July 2023

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Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach.
Hasan Şimşek, Sefa Küçükler, Cihan Gür, Mustafa İleritürk, Serpil Aygörmez

Iran J Basic Med Sci· January 2023

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