Publications by authors named "Hashan Jayarathne"

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Canagliflozin Reprograms the Aging Hippocampus in Genetically Diverse UM-HET3 Mice and Attenuates Alzheimer's-Like Pathology.
Hashan Jayarathne, Dulmalika Herath Manchanayake, Ryan Sullivan, Nina Chimienti, Omar Kadri

Aging Cell· December 2025

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Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice.
Mariah F Calubag, Ismail Ademi, Cara L Green, Hashan S M Jayarathne, Dulmalika N H Manchanayake

bioRxiv· September 2025

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The impact of inactivation of the GH/IGF axis during aging on healthspan.
Sher Bahadur Poudel, Ryan R Ruff, Zhiming He, Manisha Dixit, Godze Yildirim, Hashan Jayarathne

Geroscience· June 2025

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Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice.
José V V Isola, Subhasri Biswas, Hashan Jayarathne, Chase R Hubbart, Jessica D Hense

Geroscience· June 2025

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Canagliflozin reprograms the aging hippocampus in genetically diverse UM-HET3 mice and attenuates Alzheimer's-like pathology.
Hashan Jayarathne, Dulmalika Herath Manchanayake, Nina Chimienti, Omar Kadri, Katherine Gurdziel

bioRxiv· June 2025

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Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling.
Lucas K Debarba, Hashan S M Jayarathne, Lukas Stilgenbauer, Ana L Terra Dos Santos, Lisa Koshko

Diabetes· December 2024

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Hypothalamic sex-specific metabolic shift by canagliflozin during aging.
Hashan S M Jayarathne, Ryan Sullivan, Lukas Stilgenbauer, Lucas K Debarba, Artur Kuchumov

Geroscience· October 2024

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Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life.
Lisa Koshko, Sydney Scofield, Lucas Debarba, Lukas Stilgenbauer, Patrick Fakhoury, Hashan Jayarathne

Chemosphere· July 2023

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Repurposing Canagliflozin to target brain aging.
Hashan Jayarathne, Wanqing Liu, Marianna Sadagurski

Aging (Albany NY)· March 2023

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Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice.
Jessica M Snyder, Kerriann M Casey, Andrzej Galecki, David E Harrison, Hashan Jayarathne

Geroscience· February 2023

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Prenatal benzene exposure alters offspring hypothalamic development predisposing to metabolic disease in later life.
Lisa Koshko, Sydney Scofield, Lucas Debarba, Lukas Stilgenbauer, Mikaela Sacla, Hashan Jayarathne

bioRxiv· January 2023

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Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice.
Hashan S M Jayarathne, Lucas K Debarba, Jacob J Jaboro, Brett C Ginsburg, Richard A Miller

Aging Cell· July 2022

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17-α-Estradiol Has Sex-Specific Effects on Neuroinflammation That Are Partly Reversed by Gonadectomy.
Lucas K Debarba, Hashan S M Jayarathne, Richard A Miller, Michael Garratt, Marianna Sadagurski

J Gerontol A Biol Sci Med Sci· January 2022

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Canagliflozin extends life span in genetically heterogeneous male but not female mice.
Richard A Miller, David E Harrison, David B Allison, Molly Bogue, Lucas Debarba, Hashan Jayarathne

JCI Insight· November 2020

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Assessment of the applicability of wood anatomy and DNA barcoding to detect the timber adulterations in Sri Lanka.
Sachithrani Kannangara, Sachinthani Karunarathne, Lahiru Ranaweera, Kalpani Ananda, Disnie Ranathunga, Hashan Jayarathne

Sci Rep· March 2020

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Characterization of the FMDV-serotype-O isolates collected during 1962 and 1997 discloses new topotypes, CEY-1 and WCSA-1, and six new lineages.
Lahiru Thilanka Ranaweera, Upendra Kumari Wijesundara, Hashan Sri-Madhubashana Jayarathne, Nick Knowles, Jemma Wadsworth

Sci Rep· October 2019

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