Publications by authors named "Hazel Hunt"

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Evaluation of the Pharmacokinetics, Disposition, and Metabolism of Miricorilant, a Novel Glucocorticoid Receptor Modulator for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis in Nonclinical and Clinical Studies.
Hazel J Hunt, Kirsteen M Donaldson, Jeevan R Kunta, Joseph M Custodio

J Clin Pharmacol· January 2026

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The Selective Glucocorticoid Receptor Modulator Cort125329 Decreases Neuroinflammation and Gliosis and Enhances Myelination in the Wobbler Model of Amyotrophic Lateral Sclerosis.
Iván Esperante, Carolina Banzan, Jimena Zahn Munuera, Analía Lima, Hazel Hunt

Mol Neurobiol· September 2025

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Advancing Alzheimer's disease pharmacotherapy: efficacy of glucocorticoid modulation with dazucorilant (CORT113176) in preclinical mouse models.
Geoffrey Canet, Charleine Zussy, Mathieu Vitalis, Françoise Morin, Nathalie Chevallier, Hazel Hunt

Br J Pharmacol· May 2025

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confers resistance to antiandrogens: mechanism and therapeutic implications.
Arunachalam Sekar, Rishita Chatterjee, Boobash Raj Selvadurai, Lipika R Pal, Aakanksha Verma, Hazel Hunt

bioRxiv· January 2025

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Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice.
Max Gentenaar, Fleur L Meulmeester, Ximaine R van der Burg, Anna T Hoekstra, Hazel Hunt

Exp Neurol· April 2024

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Stress-induced Neuroinflammation of the Spinal Cord is Restrained by Cort113176 (Dazucorilant), A Specific Glucocorticoid Receptor Modulator.
Maria Meyer, Onno Meijer, Hazel Hunt, Joseph Belanoff, Analia Lima

Mol Neurobiol· January 2024

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Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice.
Jan Kroon, Max Gentenaar, Tijmen J A Moll, Hazel Hunt, Onno C Meijer

Eur J Pharmacol· October 2023

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The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol.
Andrew E Greenstein, Hazel J Hunt

Int Immunopharmacol· July 2023

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Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition.
Eva M G Viho, Jan Kroon, Richard A Feelders, René Houtman, Elisabeth S R van den Dungen, Hazel J Hunt

J Endocrinol· February 2023

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Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects: A Proof-of-Concept Study.
Hazel J Hunt, Kirsteen Donaldson, Mark Strem, Iulia Cristina Tudor, Suzanne Sweet-Smith

J Clin Psychopharmacol· February 2022

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Glucocorticoid Receptor Antagonist Alters Corticosterone and Receptor-sensitive mRNAs in the Hypoxic Neonatal Rat.
Ashley L Gehrand, Jonathan Phillips, Kyle D Welhouse, Hana Siddiqui, Matthew Schulgit, Hazel Hunt

Endocrinology· January 2022

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The development of novel glucocorticoid receptor antagonists: From rational chemical design to therapeutic efficacy in metabolic disease models.
Jan Kroon, Eva M G Viho, Max Gentenaar, Lisa L Koorneef, Cees van Kooten, Hazel Hunt

Pharmacol Res· June 2021

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An integrated framework for quantifying immune-tumour interactions in a 3D co-culture model.
Gheed Al-Hity, FengWei Yang, Eduard Campillo-Funollet, Andrew E Greenstein, Hazel Hunt

Commun Biol· June 2021

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Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells.
Andrew E Greenstein, Hazel J Hunt

Oncotarget· June 2021

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Glucocorticoid receptor modulators decrease alcohol self-administration in male rats.
M Adrienne McGinn, Brendan J Tunstall, Joel E Schlosburg, Adriana Gregory-Flores, Olivier George, Hazel J Hunt

Neuropharmacology· May 2021

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An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes.
Joseph M Custodio, Kirsteen M Donaldson, Hazel J Hunt

J Clin Pharmacol· February 2021

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Mifepristone Decreases Chronic Voluntary Ethanol Consumption in Rhesus Macaques.
Vanessa A Jimenez, Nicole A R Walter, Tatiana A Shnitko, Natali Newman, Kaya Diem, Hazel Hunt

J Pharmacol Exp Ther· November 2020

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The selective glucocorticoid receptor antagonist CORT125281 has tissue-specific activity.
Lisa L Koorneef, Jan Kroon, Eva M G Viho, Lucas F Wahl, Kim M L Heckmans, Hazel Hunt

J Endocrinol· July 2020

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Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation.
Eva M G Viho, Jacobus C Buurstede, Ahmed Mahfouz, Lisa L Koorneef, Lisa T C M van Weert, Hazel J Hunt

Neuroendocrinology· June 2020

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Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice.
Antonia M Savarese, Angela R Ozburn, Pamela Metten, Jason P Schlumbohm, Wyatt R Hack, Hazel Hunt

Alcohol Clin Exp Res· May 2020

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Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases.
Alejandro F De Nicola, Maria Meyer, Rachida Guennoun, Michael Schumacher, Hazel Hunt

Int J Mol Sci· March 2020

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Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration.
Maria Meyer, Maria Sol Kruse, Laura Garay, Analia Lima, Paulina Roig, Hazel Hunt

Brain Res· January 2020

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Glucocorticoid receptors signaling impairment potentiates amyloid-β oligomers-induced pathology in an acute model of Alzheimer's disease.
Geoffrey Canet, Fanny Pineau, Charleine Zussy, Célia Hernandez, Hazel Hunt

FASEB J· January 2020

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Selective Glucocorticoid Receptor Modulation Prevents and Reverses Nonalcoholic Fatty Liver Disease in Male Mice.
Lisa L Koorneef, José K van den Heuvel, Jan Kroon, Mariëtte R Boon, Peter A C 't Hoen, Hazel Hunt

Endocrinology· December 2018

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Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses.
Scherazad Kootar, Marie-Lise Frandemiche, Gihen Dhib, Xavier Mouska, Thomas Lorivel, Hazel Hunt

Neurobiol Dis· October 2018

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