Publications by authors named "Hebing Chen"

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Dual-Phase deep learning Enhances detection of incidental small pancreatic cystic lesion (0.5-3 cm) on Contrast-Enhanced CT.
Wenyi Deng, Fuze Cong, Feiyang Xie, Hebing Chen, Xiheng Wang

Eur J Radiol· January 2026

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Excessive DNA Double-Strand Breaks-Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xiaochen Bo, Hebing Chen

Adv Sci (Weinh)· December 2025

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SCOPE-C reveals long-range enhancer networks emerging as key regulators during human cortical neurogenesis.
Lumeng Jia, Yingping Hou, Zejia Cui, Xin Luo, Jiali Duan, Hebing Chen, Cheng Li

Neuron· December 2025

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Human pluripotent stem cell-derived skin organoids enabled pathophysiological model of Mycobacterium tuberculosis infection.
Liang Yue, Yating Liang, Pengfei Zhong, Leiming Fang, Zhimin Yun, Chengjun Wu, Hebing Chen, Xiaochen Qiu, Xiaochen Bo

Nat Commun· December 2025

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Targeting the origins of multiple myeloma along hematopoietic stem cell lymphoid lineage differentiation.
Jiaojiao Guo, Yaru Li, Zhiling Yan, Qing Li, Zhenhao Liu, Xun Chen, Xiaochen Bo, Tao Cheng, Hebing Chen

Sci Transl Med· November 2025

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ChromInSight: Revealing DNA Double-Strand Breaks Through Chromatin Structural Insights With an Interpretable Graph Neural Network Framework.
Kang Xu, Zongyuan Yu, Canzhuang Sun, Conglin Gou, Jiangyue Zhu, Xiaochen Bo, Hebing Chen

Adv Sci (Weinh)· September 2025

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TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesis.
Qiaowei Liu, Shuai Jiang, Xiang Xu, Kang Xu, Yawen Luo, Xiaochen Bo, Hebing Chen, Xiaohua Chen

Nat Commun· September 2025

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ANP32E expression in pancreatic cancer is associated with impaired gemcitabine efficacy and poor patient prognosis.
Xiaohong Liu, Yelin Zhao, Li Zhang, Junting Wang, Liaoxin Luo, Yuchen Shi, Chenyu Yuan, Hebing Chen

Mol Cell Probes· August 2025

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The hierarchical folding dynamics of topologically associating domains during early embryo development.
Xuemei Bai, Xiaohan Tang, Yuyang Wang, Shutong Yue, Xiang Xu, Bijia Chen, Xiaochen Bo, Hebing Chen

BMC Biol· July 2025

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Fragment dispersity index analysis of cfDNA fragments reveals chromatin accessibility and enables early cancer detection.
Yunze Wang, Yuying Hou, Zhankun Xiong, Libo Lu, Zhanxiang Zong, Hebing Chen

Cell Rep Methods· July 2025

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Explosive tumor growth in a patient with colon cancer is associated with reduced neoantigen levels and decreased interferon-gamma (IFN-γ) signaling.
Yaqi Wang, Jiahua Lu, Dandan Huang, Pengju Chen, Jingyi Shi, Jie Cheng, Hebing Chen, Cheng Li

BMC Cancer· June 2025

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3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression.
Xiang Xu, Jingbo Gan, Zhaoya Gao, Ruifeng Li, Dandan Huang, Xiaochen Bo, Hebing Chen, Cheng Li

Commun Biol· March 2025

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Author Correction: 3D genome landscape of primary and metastatic colorectal carcinoma reveals the regulatory mechanism of tumorigenic and metastatic gene expression.
Xiang Xu, Jingbo Gan, Zhaoya Gao, Ruifeng Li, Dandan Huang, Xiaochen Bo, Hebing Chen, Cheng Li

Commun Biol· March 2025

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Identifying associations between short tandem repeat sequences and gene expression in yeast reveals specific repeated motifs encoding transcriptional regulatory proteins.
Zongyuan Yu, Yating Liang, Meida Xiang, Kang Xu, Xiang Xu, Bijia Chen, Xiaochen Bo, Hebing Chen

Comput Struct Biotechnol J· February 2025

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Long-range transcription factor binding sites clustered regions may mediate transcriptional regulation through phase-separation interactions in early human embryo.
Mengge Tian, Xiaohan Tang, Zhangyi Ouyang, Yaru Li, Xuemei Bai, Bijia Chen, Xiaochen Bo, Hebing Chen

Comput Struct Biotechnol J· December 2024

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mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer.
Guoqing Lv, Qian Wang, Lin Lin, Qiao Ye, Xi Li, Hebing Chen

Nat Cell Biol· September 2024

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The developmental and evolutionary characteristics of transcription factor binding site clustered regions based on an explainable machine learning model.
Zhangyi Ouyang, Feng Liu, Wanying Li, Junting Wang, Bijia Chen, Cheng Li, Xiaochen Bo, Hebing Chen

Nucleic Acids Res· July 2024

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CGMega: explainable graph neural network framework with attention mechanisms for cancer gene module dissection.
Hao Li, Zebei Han, Yu Sun, Fu Wang, Pengzhen Hu, Hebing Chen, Xiaochen Bo

Nat Commun· July 2024

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A comprehensive benchmarking with interpretation and operational guidance for the hierarchy of topologically associating domains.
Jingxuan Xu, Xiang Xu, Dandan Huang, Yawen Luo, Lin Lin, Yu Cheng, Xiaochen Bo, Hebing Chen

Nat Commun· May 2024

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Guiding post-pancreaticoduodenectomy interventions for pancreatic cancer patients utilizing decision tree models.
Haixin Wang, Bo Shen, Peiheng Jia, Hao Li, Xuemei Bai, Hebing Chen

Front Oncol· May 2024

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Stratifying TAD boundaries pinpoints focal genomic regions of regulation, damage, and repair.
Bijia Chen, Chao Ren, Zhangyi Ouyang, Jingxuan Xu, Kang Xu, Xiaochen Bo, Hebing Chen

Brief Bioinform· May 2024

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The PTM profiling of CTCF reveals the regulation of 3D chromatin structure by O-GlcNAcylation.
Xiuxiao Tang, Pengguihang Zeng, Kezhi Liu, Li Qing, Yifei Sun, Hebing Chen, Chengfang Xu

Nat Commun· April 2024

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SEPDB: a database of secreted proteins.
Ruiqing Wang, Chao Ren, Tian Gao, Hao Li, Xiaochen Bo, Hebing Chen

Database (Oxford)· February 2024

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Ablation alone is noninferior to radiotherapy plus ablation in the patients with early-stage hepatocellular carcinoma: a population-based study.
Yusheng Guo, Hebing Chen, Jiayu Wan, Yanqiao Ren, Feihong Wu, Lei Chen

Sci Rep· January 2024

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Dual-Layer Spectral Detector Computed Tomography Quantitative Parameters: A Potential Tool for Lymph Node Activity Determination in Lymphoma Patients.
Hebing Chen, Yuxiang Fang, Jin Gu, Peng Sun, Lian Yang

Diagnostics (Basel)· January 2024

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