Publications by authors named "Helen C Steel"

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A Pilot Study on the Potential Pathological Link Between Oxidative Stress Markers and Renal Function in People Living with HIV.
Joel Choshi, Haskly Mokoena, Helen C Steel, Brian T Flepisi, Kabelo Mokgalaboni

Int J Mol Sci· November 2025

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Sustained Activation of Myeloperoxidase Is Associated with Oxidative Stress and Inflammation in People Living with the Human Immunodeficiency Virus at Risk of Cardiovascular Disease.
Haskly Mokoena, Joel Choshi, Sidney Hanser, Sihle E Mabhida, Helen C Steel

Int J Mol Sci· October 2025

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Immunopathogenesis and Therapeutic Implications in Basal Cell Carcinoma: Current Concepts and Future Directions.
Helen C Steel, Theresa M Rossouw, Ronald Anderson, Lindsay Anderson, Daniel van Tonder

Medicina (Kaunas)· October 2025

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Vascular endothelial growth factor A: friend or foe in the pathogenesis of HIV and SARS-CoV-2 infections?
Mieke A van der Mescht, Helen C Steel, Ronald Anderson, Theresa M Rossouw

Front Cell Infect Microbiol· May 2025

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Current and Emerging Insights into the Causes, Immunopathogenesis, and Treatment of Cutaneous Squamous Cell Carcinoma.
Ronald Anderson, Nomzamo M Mkhize, Mahlatse M C Kgokolo, Helen C Steel, Theresa M Rossouw

Cancers (Basel)· May 2025

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T-Cell Phenotypes and Systemic Cytokine Profiles of People Living with HIV Admitted to Hospital with COVID-19.
Mieke A van der Mescht, Helen C Steel, Zelda de Beer, Andries Masenge, Fareed Abdullah

Microorganisms· October 2024

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Aberrant innate immune profile associated with COVID-19 mortality in Pretoria, South Africa.
Mieke A van der Mescht, Zelda de Beer, Helen C Steel, Ronald Anderson, Andries Masenge

Clin Immunol· September 2024

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Comparative Effects of Efavirenz and Dolutegravir on Metabolomic and Inflammatory Profiles, and Platelet Activation of People Living with HIV: A Pilot Study.
Crystal G Roux, Shayne Mason, Louise D V du Toit, Jan-Gert Nel, Theresa M Rossouw, Helen C Steel

Viruses· September 2024

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Persistently Elevated Expression of Systemic, Soluble Co-Inhibitory Immune Checkpoint Molecules in People Living with HIV before and One Year after Antiretroviral Therapy.
Robyn-Brooke Labuschagne Naidoo, Helen C Steel, Annette J Theron, Ronald Anderson, Gregory R Tintinger

Pathogens· June 2024

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Transforming growth factor-β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma.
Mahlatse C M Kgokolo, Nonkululeko Z Malinga, Helen C Steel, Pieter W A Meyer, Teresa Smit

Transl Oncol· April 2024

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Comparison of platelet-and endothelial-associated biomarkers of disease activity in people hospitalized with Covid-19 with and without HIV co-infection.
Mieke A van der Mescht, Helen C Steel, Zelda de Beer, Fareed Abdullah, Veronica Ueckermann

Front Immunol· August 2023

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Pro-Tumorigenic and Thrombotic Activities of Platelets in Lung Cancer.
Ronald Anderson, Bernardo L Rapoport, Helen C Steel, Annette J Theron

Int J Mol Sci· July 2023

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Dysregulation of systemic soluble immune checkpoints in early breast cancer is attenuated following administration of neoadjuvant chemotherapy and is associated with recovery of CD27, CD28, CD40, CD80, ICOS and GITR and substantially increased levels of PD-L1, LAG-3 and TIM-3.
Bernardo L Rapoport, Helen C Steel, Carol A Benn, Simon Nayler, Teresa Smit

Front Oncol· March 2023

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Immune and Metabolic Alterations in Children with Perinatal HIV Exposure.
Louise D V du Toit, Andrea Prinsloo, Helen C Steel, Ute Feucht, Roan Louw

Viruses· January 2023

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Dolutegravir potentiates platelet activation by a calcium-dependent, ionophore-like mechanism.
Morris Madzime, Annette J Theron, Ronald Anderson, Gregory R Tintinger, Helen C Steel

J Immunotoxicol· December 2022

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Pro-Inflammatory Interactions of Dolutegravir with Human Neutrophils in an In Vitro Study.
Annette J Theron, Ronald Anderson, Morris Madzime, Theresa M Rossouw, Helen C Steel

Molecules· December 2022

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Assessment of the efficacy of clofazimine alone and in combination with primary agents against Mycobacterium tuberculosis in vitro.
Sizeka A Mashele, Helen C Steel, Maborwa T Matjokotja, Sam S M Rasehlo, Ronald Anderson

J Glob Antimicrob Resist· June 2022

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Systemic Immune Dysregulation in Early Breast Cancer Is Associated With Decreased Plasma Levels of Both Soluble Co-Inhibitory and Co-Stimulatory Immune Checkpoint Molecules.
Bernardo L Rapoport, Helen C Steel, Nomsa Hlatshwayo, Annette J Theron, Pieter W A Meyer

Front Immunol· June 2022

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Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1 and TIM-3 are markedly increased in basal cell carcinoma.
Nonkululeko Z Malinga, Shalete C Siwele, Helen C Steel, Luyanda L I Kwofie, Pieter W A Meyer

Transl Oncol· May 2022

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Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients.
Mahlatse C M Kgokolo, Katherine Anderson, Shalate C Siwele, Helen C Steel, Luyanda L I Kwofie

Front Oncol· February 2022

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Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets.
Morris Madzime, Theresa M Rossouw, Annette J Theron, Ronald Anderson, Helen C Steel

Front Immunol· September 2021

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Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy.
Stefanie Kroeze, Theresa M Rossouw, Helen C Steel, Ferdinand W Wit, Cissy M Kityo

J Infect Dis· August 2021

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Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets Interference With Phosphatidylinositol 3-Kinase.
Gregory R Tintinger, Annette J Theron, Helen C Steel, Moloko C Cholo, Jan G Nel

Front Immunol· July 2021

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Differential Responsiveness of the Platelet Biomarkers, Systemic CD40 Ligand, CD62P, and Platelet-Derived Growth Factor-BB, to Virally-Suppressive Antiretroviral Therapy.
Helen C Steel, W D Francois Venter, Annette J Theron, Ronald Anderson, Charles Feldman

Front Immunol· June 2021

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ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors.
Ronald Anderson, Annette J Theron, Helen C Steel, Jan G Nel, Gregory R Tintinger

Pharmaceuticals (Basel)· November 2020

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