Publications by authors named "Helen Scharfman"

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Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy.
John J LaFrancois, Meghan Kennedy, Monarchsinh Rathod, Bina Santoro, Christos Panagiotis Lisgaras, Helen E Scharfman

Neurobiol Dis· January 2026

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Restoration of sFRP3 Preserves the Neural Stem Cell Pool and Spatial Discrimination Ability in a Mouse Model of Alzheimer's Disease.
Chia-Hsuan Fu, Jin Park, Umberto Tosi, Francisco A Blanco, Manuel Silva-Pérez, Helen Scharfman

J Neurosci· December 2025

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Chemogenetic activation of hippocampal area CA2 promotes acute and chronic seizures in a mouse model of epilepsy.
John J LaFrancois, Meghan Kennedy, Monarchsinh Rathod, Bina Santoro, Christos Panagiotis Lisgaras, Helen E Scharfman

bioRxiv· December 2025

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Getting -isfaction.
Helen E Scharfman

Epilepsy Curr· November 2025

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Opposing interictal dynamics in Alzheimer's disease and epilepsy.
Christos Panagiotis Lisgaras, Helen E Scharfman

Prog Neurobiol· November 2025

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Clioquinol "" for Drug-Resistant Epilepsy-With an After Taste.
Helen E Scharfman

Epilepsy Curr· November 2025

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Testosterone and 17β-estradiol regulate hippocampal area CA3 sharp waves in male and female rats.
Patrice Pearce, John J LaFrancois, Vanessa Skucas, Daniel Friedman, André A Fenton, Helen E Scharfman

Cell Rep· July 2025

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Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer's disease.
Helen E Scharfman, Korey Kam, Áine M Duffy, John J LaFrancois, Paige Leary

Front Dement· June 2025

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Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer's disease.
David Alcantara-Gonzalez, Meghan Kennedy, Chiara Criscuolo, Justin Botterill, Helen E Scharfman

Alzheimers Res Ther· May 2025

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Adenosine Makes a Scene.
Helen E Scharfman

Epilepsy Curr· April 2025

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Field EPSPs of Dentate Gyrus Granule Cells Studied by Selective Optogenetic Activation of Hilar Mossy Cells in Hippocampal Slices.
Hannah L Bernstein, Yi-Ling Lu, Justin J Botterill, Áine M Duffy, John J LaFrancois, Helen E Scharfman

Hippocampus· January 2025

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Towards an Understanding of the Dentate Gyrus Hilus.
Helen E Scharfman

Hippocampus· January 2025

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Field EPSPs of dentate gyrus granule cells studied by selective optogenetic activation of hilar mossy cells in hippocampal slices.
Hannah L Bernstein, Yi-Ling Lu, Justin J Botterill, Áine M Duffy, John J LaFrancois, Helen E Scharfman

bioRxiv· November 2024

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Increasing adult-born neurons protects mice from epilepsy.
Swati Jain, John J LaFrancois, Kasey Gerencer, Justin J Botterill, Meghan Kennedy, Helen E Scharfman

Elife· October 2024

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Increasing adult-born neurons protects mice from epilepsy.
Swati Jain, John J LaFrancois, Kasey Gerencer, Justin J Botterill, Meghan Kennedy, Helen E Scharfman

bioRxiv· September 2024

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Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.
Elissavet Chartampila, Karim S Elayouby, Paige Leary, John J LaFrancois, David Alcantara-Gonzalez, Helen E Scharfman

Elife· June 2024

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Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.
Elissavet Chartampila, Karim S Elayouby, Paige Leary, John J LaFrancois, David Alcantara-Gonzalez, Helen E Scharfman

bioRxiv· May 2024

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Dentate Gyrus Granule Cells Show Stability of BDNF Protein Expression in Mossy Fiber Axons with Age, and Resistance to Alzheimer's Disease Neuropathology in a Mouse Model.
Chiara Criscuolo, Elissavet Chartampila, Stephen D Ginsberg, Helen E Scharfman

eNeuro· March 2024

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Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer's disease.
David Alcantara-Gonzalez, Meghan Kennedy, Chiara Criscuolo, Justin Botterill, Helen E Scharfman

bioRxiv· February 2024

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High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer's Disease.
Christos Panagiotis Lisgaras, Helen E Scharfman

bioRxiv· November 2023

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Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy.
Alexander C Whitebirch, Bina Santoro, Anastasia Barnett, Christos Panagiotis Lisgaras, Helen E Scharfman

J Neurosci· October 2023

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Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum.
Christos Panagiotis Lisgaras, Helen E Scharfman

Neurobiol Dis· October 2023

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Assessments of dentate gyrus function: discoveries and debates.
Mia Borzello, Steve Ramirez, Alessandro Treves, Inah Lee, Helen Scharfman

Nat Rev Neurosci· August 2023

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Stability of dentate gyrus granule cell mossy fiber BDNF protein expression with age and resistance of granule cells to Alzheimer's disease neuropathology in a mouse model.
Chiara Criscuolo, Elissavet Chartampila, Stephen D Ginsberg, Helen E Scharfman

bioRxiv· May 2023

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