Publications by authors named "Helga Rothe"

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Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) - State of the science and next steps.
Anthony M Bowden, Sylvia E Escher, Jane Rose, Nikaeta Sadekar, Grace Patlewicz, Helga Rothe

Regul Toxicol Pharmacol· August 2023

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Corrigendum to partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids.
Corie A Ellison, Kevin O Tankersley, Cindy M Obringer, Greg J Carr, John Manwaring, Helga Rothe

Toxicol In Vitro· March 2021

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Partition coefficient and diffusion coefficient determinations of 50 compounds in human intact skin, isolated skin layers and isolated stratum corneum lipids.
Corie A Ellison, Kevin O Tankersley, Cindy M Obringer, Greg J Carr, John Manwaring, Helga Rothe

Toxicol In Vitro· December 2020

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Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol.
Nicola J Hewitt, Sébastien Grégoire, Richard Cubberley, Hélène Duplan, Joan Eilstein, Helga Rothe

J Appl Toxicol· March 2020

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Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics-relevant chemicals.
Joan Eilstein, Sébastien Grégoire, Aurélie Fabre, Eric Arbey, Camille Géniès, Helga Rothe

J Appl Toxicol· March 2020

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Comparison of the metabolism of 10 cosmetics-relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants.
Camille Géniès, Carine Jacques-Jamin, Hélène Duplan, Helga Rothe, Corie Ellison

J Appl Toxicol· February 2020

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Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study.
Sébastien Grégoire, Richard Cubberley, Hélène Duplan, Joan Eilstein, Nicola J Hewitt, Helga Rothe

Skin Pharmacol Physiol· November 2019

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A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme.
Bertrand Desprez, Matt Dent, Detlef Keller, Martina Klaric, Gladys Ouédraogo, Helga Rothe

Toxicol In Vitro· August 2018

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Comparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin.
Carine Jacques-Jamin, Hélène Duplan, Helga Rothe, Ophelie Vaillant, Joan Eilstein

Skin Pharmacol Physiol· June 2018

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Application of in vitro skin penetration measurements to confirm and refine the quantitative skin sensitization risk assessment of methylisothiazolinone.
Helga Rothe, Cindy A Ryan, Leanne Page, Joanne Vinall, Carsten Goebel

Regul Toxicol Pharmacol· December 2017

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Suitability of the in vitro Caco-2 assay to predict the oral absorption of aromatic amine hair dyes.
Cindy Obringer, John Manwaring, Carsten Goebel, Nicola J Hewitt, Helga Rothe

Toxicol In Vitro· April 2016

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Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern).
Faith M Williams, Helga Rothe, Gordon Barrett, Alessandro Chiodini, Jacqueline Whyte

Regul Toxicol Pharmacol· April 2016

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An in vitro skin penetration model for compromised skin: estimating penetration of polyethylene glycol [¹⁴C]-PEG-7 phosphate.
Swatee Dey, Helga Rothe, Leanne Page, Robert O'Connor, Sara Farahmand

Skin Pharmacol Physiol· September 2015

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Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro.
John Manwaring, Helga Rothe, Cindy Obringer, David J Foltz, Timothy R Baker

Toxicol Appl Pharmacol· September 2015

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Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction.
Carsten Goebel, John Troutman, Jenny Hennen, Helga Rothe, Harald Schlatter

Toxicol Appl Pharmacol· February 2014

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The hair dyes PPD and PTD fail to induce a T(H)2 immune response following repeated topical application in BALB/c mice.
Helga Rothe, Katherine Sarlo, Heike Scheffler, Carsten Goebel

J Immunotoxicol· May 2011

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