Publications by authors named "Helmut Brade"

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Antigen binding by conformational selection in near-germline antibodies.
Ryan J Blackler, Sven Müller-Loennies, Barbara Pokorny-Lehrer, Max S G Legg, Lore Brade, Helmut Brade

J Biol Chem· May 2022

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Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.
Omid Haji-Ghassemi, Sven Müller-Loennies, Cory L Brooks, C Roger MacKenzie, Nathanael Caveney, Lore Brade, Helmut Brade

Biochemistry· February 2019

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The Combining Sites of Anti-lipid A Antibodies Reveal a Widely Utilized Motif Specific for Negatively Charged Groups.
Omid Haji-Ghassemi, Sven Müller-Loennies, Teresa Rodriguez, Lore Brade, Hans-Dieter Grimmecke, Helmut Brade

J Biol Chem· May 2016

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Structural Basis for Antibody Recognition of Lipid A: INSIGHTS TO POLYSPECIFICITY TOWARD SINGLE-STRANDED DNA.
Omid Haji-Ghassemi, Sven Müller-Loennies, Teresa Rodriguez, Lore Brade, Paul Kosma, Helmut Brade

J Biol Chem· August 2015

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Groove-type recognition of chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.
Omid Haji-Ghassemi, Sven Müller-Loennies, Radka Saldova, Mohankumar Muniyappa, Lore Brade, Helmut Brade

J Biol Chem· June 2014

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Evaluation of a LPS-based glycoconjugate vaccine against bovine Escherichia coli mastitis: Formation of LPS Abs in cows after immunization with E. coli core oligosaccharides conjugated to hemocyanine.
Lore Brade, Selma Hensen, Helmut Brade

Innate Immun· March 2014

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Molecular and structural basis of inner core lipopolysaccharide alterations in Escherichia coli: incorporation of glucuronic acid and phosphoethanolamine in the heptose region.
Gracjana Klein, Sven Müller-Loennies, Buko Lindner, Natalia Kobylak, Helmut Brade

J Biol Chem· March 2013

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Intact rough- and smooth-form lipopolysaccharides from Escherichia coli separated by preparative gel electrophoresis exhibit differential biologic activity in human macrophages.
Elder Pupo, Buko Lindner, Helmut Brade, Andra B Schromm

FEBS J· February 2013

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Exploring the cross-reactivity of S25-2: complex with a 5,6-dehydro-Kdo disaccharide.
Cory L Brooks, Kurt Wimmer, Paul Kosma, Sven Müller-Loennies, Lore Brade, Helmut Brade

Acta Crystallogr Sect F Struct Biol Cryst Commun· January 2013

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Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS.
Kathryn Gomery, Sven Müller-Loennies, Cory L Brooks, Lore Brade, Paul Kosma, Helmut Brade

Proc Natl Acad Sci U S A· December 2012

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Immunization with an anti-idiotypic antibody against the broadly lipopolysaccharide-reactive antibody WN1 222-5 induces Escherichia coli R3-core-type specific antibodies in rabbits.
Lore Brade, Holger Heine, Satish Raina, Gracjana Klein, Franco Di Padova, Helmut Brade

Innate Immun· April 2012

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Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose.
Gracjana Klein, Buko Lindner, Helmut Brade, Satish Raina

J Biol Chem· December 2011

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Structural insights into parallel strategies for germline antibody recognition of lipopolysaccharide from Chlamydia.
Dylan W Evans, Sven Müller-Loennies, Cory L Brooks, Lore Brade, Paul Kosma, Helmut Brade

Glycobiology· August 2011

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The lipopolysaccharide of the mastitis isolate Escherichia coli strain 1303 comprises a novel O-antigen and the rare K-12 core type.
Katarzyna A Duda, Buko Lindner, Helmut Brade, Andreas Leimbach, Elżbieta Brzuszkiewicz

Microbiology (Reading)· June 2011

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A common NH53K mutation in the combining site of antibodies raised against chlamydial LPS glycoconjugates significantly increases avidity.
Ryan J Blackler, Sven Müller-Loennies, Cory L Brooks, Dylan W Evans, Lore Brade, Helmut Brade

Biochemistry· April 2011

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Efficient Synthesis of 4-Amino-4-deoxy-L-arabinose and Spacer-equipped 4-Amino-4-deoxy-L-arabinopyranosides by Transglycosylation Reactions.
Bernhard Müller, Markus Blaukopf, Andreas Hofinger, Alla Zamyatina, Helmut Brade

Synthesis (Stuttg)· September 2010

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Synthesis of a neoglycoconjugate containing a Chlamydophila psittaci-specific branched Kdo trisaccharide epitope.
Paul Kosma, Andreas Hofinger, Sven Müller-Loennies, Helmut Brade

Carbohydr Res· March 2010

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The role of CDR H3 in antibody recognition of a synthetic analog of a lipopolysaccharide antigen.
Cory L Brooks, Ryan J Blackler, Georg Sixta, Paul Kosma, Sven Müller-Loennies, Lore Brade, Helmut Brade

Glycobiology· February 2010

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Glycosyltransferases involved in the biosynthesis of the inner core region of different lipopolysaccharides.
Sabine Gronow, Guoqing Xia, Helmut Brade

Eur J Cell Biol· January 2010

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Antibodies raised against chlamydial lipopolysaccharide antigens reveal convergence in germline gene usage and differential epitope recognition.
Cory L Brooks, Sven Müller-Loennies, Svetlana N Borisova, Lore Brade, Paul Kosma, Helmut Brade

Biochemistry· January 2010

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Monoclonal antibody S60-4-14 reveals diagnostic potential in the identification of Pseudomonas aeruginosa in lung tissues of cystic fibrosis patients.
Kai Schmengler, Torsten Goldmann, Lore Brade, Patricia M Sánchez Carballo, Sandra Albrecht, Helmut Brade

Eur J Cell Biol· January 2010

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Analysis of cross-reactive and specific anti-carbohydrate antibodies against lipopolysaccharide from Chlamydophila psittaci.
Sandra Gerstenbruch, Cory L Brooks, Paul Kosma, Lore Brade, C Roger Mackenzie, Helmut Brade

Glycobiology· January 2010

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Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages.
Daniel Prantner, Toni Darville, James D Sikes, Charles W Andrews, Helmut Brade

Infect Immun· December 2009

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Synthesis and antigenic properties of C-7-modified Kdo mono- and disaccharide ligands and Kdo disaccharide interresidue lactones.
Georg Sixta, Kurt Wimmer, Andreas Hofinger, Helmut Brade, Paul Kosma

Carbohydr Res· September 2009

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Escherichia coli K-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases: minimal lipopolysaccharide structure and induction of envelope stress response.
Gracjana Klein, Buko Lindner, Werner Brabetz, Helmut Brade, Satish Raina

J Biol Chem· June 2009

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