Publications by authors named "Hend Kothayer"

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Novel 1,3,4-oxadiazole-nicotinamide hybrids as non-classical AHL mimics quorum sensing inhibitors of Pseudomonas aeruginosa: design, synthesis and biological evaluation.
Mohamed M S Hamoud, Amany M Ghanim, Abdalla E A Hassan, Hanan A Abdel-Fattah, Hisham A Abbas, Hend Kothayer

BMC Chem· July 2025

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Vitamin D3 mitigates myopathy and metabolic dysfunction in rats with metabolic syndrome: the potential role of dipeptidyl peptidase-4.
Nourhan O Shoier, Salah A Ghareib, Hend Kothayer, Amira Ebrahim Alsemeh, Shaimaa S El-Sayed

Naunyn Schmiedebergs Arch Pharmacol· April 2025

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Novel 2-[thio]acetamide linked quinazoline/1,2,4-triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers.
Ahmed S Abdelkhalek, Hend Kothayer, Mostafa K Soltan, Samy M Ibrahim, Samar S Elbaramawi

Arch Pharm (Weinheim)· July 2024

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Triple targeting of mutant EGFR, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation.
Hend Kothayer, Samar Rezq, Ahmed S Abdelkhalek, Damian G Romero, Samar S Elbaramawi

J Enzyme Inhib Med Chem· December 2023

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Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity.
Sara Elsayed, Ahmed S Abdelkhalek, Samar Rezq, Mansour E Abu Kull, Damian G Romero, Hend Kothayer

Eur J Med Chem· November 2023

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Synthesis of 1,2,4-triazole and 1,3,4-oxadiazole derivatives as inhibitors for STAT3 enzymes of breast cancer.
Sherif M Fawzy, Yasser M Loksha, Mohamed El-Sadek, Samy M Ibrahim, Botros Y Beshay, Hend Kothayer

Arch Pharm (Weinheim)· November 2023

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Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines.
Ahmed S Abdelkhalek, Hend Kothayer, Samar Rezq, Khaled Y Orabi, Damian G Romero

Eur J Med Chem· August 2023

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Phenylalanyl tRNA synthetase (PheRS) substrate mimics: design, synthesis, molecular dynamics and antimicrobial evaluation.
Nada A Noureldin, Jennifer Richards, Hend Kothayer, Mohammed M Baraka, Sobhy M Eladl

RSC Adv· January 2022

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Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities.
Asmaa Sakr, Samar Rezq, Samy M Ibrahim, Eman Soliman, Mohamed M Baraka, Hend Kothayer

J Enzyme Inhib Med Chem· December 2021

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Quinazoline-tethered hydrazone: A versatile scaffold toward dual anti-TB and EGFR inhibition activities in NSCLC.
Aya M Emam, Achyut Dahal, Sitanshu S Singh, Rodrigo D Tosso, Samy M Ibrahim, Hend Kothayer

Arch Pharm (Weinheim)· December 2021

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Quinazolinone dimers as a potential new class of safer Kv1 inhibitors: Overcoming hERG, sodium and calcium channel affinities.
Aya M Emam, Steve Peigneur, Anne-Sophie Depuydt, Samy M Ibrahim, Ernesto Lopes Pinheiro-Junior, Hend Kothayer

Bioorg Chem· October 2021

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Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues.
Nada A Noureldin, Jennifer Richards, Hend Kothayer, Mohammed M Baraka, Sobhy M Eladl

BMC Chem· October 2021

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Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition.
Amany M Ghanim, Samar Rezq, Tarek S Ibrahim, Damian G Romero, Hend Kothayer

Eur J Med Chem· July 2021

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Corrigendum to "Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization" [Nanomedicine 12 (3) (2016), 745-757].
Brittany Haynes, Yanhua Zhang, Fangchao Liu, Jing Li, Sarah Petit, Hend Kothayer

Nanomedicine· June 2019

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Synthesis, in vivo and in silico evaluation of novel 2,3-dihydroquinazolin-4(1H)-one derivatives as potential anticonvulsant agents.
Hend Kothayer, Samy M Ibrahim, Moustafa K Soltan, Samar Rezq, Shireen S Mahmoud

Drug Dev Res· May 2019

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1,4-Dihydroquinazolin-3(2H)-yl benzamide derivatives as anti-inflammatory and analgesic agents with an improved gastric profile: Design, synthesis, COX-1/2 inhibitory activity and molecular docking study.
Asmaa Sakr, Hend Kothayer, Samy M Ibrahim, Mohamed M Baraka, Samar Rezq

Bioorg Chem· March 2019

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Design, synthesis and biological evaluation of novel quinazoline-2,4-diones conjugated with different amino acids as potential chitin synthase inhibitors.
Nada A Noureldin, Hend Kothayer, El-Sayed M Lashine, Mohamed M Baraka, Yanrong Huang

Eur J Med Chem· May 2018

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Synthesis, Anticonvulsant Activity, and SAR Study of Novel 4-Quinazolinone Derivatives.
Nada A Noureldin, Hend Kothayer, El-Sayed M Lashine, Mohamed M Baraka, Wafaa El-Eraky

Arch Pharm (Weinheim)· February 2017

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Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization.
Brittany Haynes, Yanhua Zhang, Fangchao Liu, Jing Li, Sarah Petit, Hend Kothayer

Nanomedicine· April 2016

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Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors.
Hend Kothayer, Sebastian M Spencer, Kaushlendra Tripathi, Andrew D Westwell, Komaraiah Palle

Bioorg Med Chem Lett· April 2016

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Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides.
Hend Kothayer, Abdalla A Elshanawani, Mansour E Abu Kull, Osama I El-Sabbagh, Malathy P V Shekhar

Bioorg Med Chem Lett· December 2013

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Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization.
Matthew A Sanders, Ghali Brahemi, Pratima Nangia-Makker, Vitaly Balan, Matteo Morelli, Hend Kothayer

Mol Cancer Ther· April 2013

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Synthesis of new 2,3-dihydroquinazolin-4(1H)-one derivatives for analgesic and anti-inflammatory evaluation.
Osama I El-Sabbagh, Samy M Ibrahim, Mohamed M Baraka, Hend Kothayer

Arch Pharm (Weinheim)· May 2010

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