Publications by authors named "Henk Lang"

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The CIpP activator, TR-57, is highly effective as a single agent and in combination with venetoclax against CLL cells .
Narjis Fatima, Yandong Shen, Kyle Crassini, Olivia Burling, Lauren Thurgood, Henk Lang

Leuk Lymphoma· May 2024

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Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome.
Mark F Mabanglo, Keith S Wong, Marim M Barghash, Elisa Leung, Stephanie H W Chuang, Henk Lang

Structure· February 2023

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Characterization of TR-107, a novel chemical activator of the human mitochondrial protease ClpP.
Emily M J Fennell, Lucas J Aponte-Collazo, Joshua D Wynn, Kristina Drizyte-Miller, Elisa Leung, Henk Lang

Pharmacol Res Perspect· August 2022

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The ClpP activator ONC-212 (TR-31) inhibits BCL2 and B-cell receptor signaling in CLL.
Narjis Fatima, Yandong Shen, Kyle Crassini, Edwin J Iwanowicz, Henk Lang

EJHaem· February 2021

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Novel-smoothened inhibitors for therapeutic targeting of naïve and drug-resistant hedgehog pathway-driven cancers.
Qing-Rou Li, Hui Zhao, Xue-Sai Zhang, Henk Lang, Ker Yu

Acta Pharmacol Sin· February 2019

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Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
Timothy C Gahman, Mark R Herbert, Henk Lang, Angie Thayer, Kent T Symons

Bioorg Med Chem Lett· November 2011

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Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox.
Daniel S Sem, Bonnie Bertolaet, Brian Baker, Edcon Chang, Aurora D Costache, Henk Lang

Chem Biol· February 2004

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