Publications by authors named "Henry Duff"

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Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.
Therese C Ku, Jianjing Cao, Sung Joon Won, Jiqing Guo, Gisela A Camacho-Hernandez, Henry J Duff

ACS Pharmacol Transl Sci· February 2024

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Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes.
Anna Janz, Katharina Walz, Alexandra Cirnu, Jessica Surjanto, Daniela Urlaub, Henry J Duff

Mol Metab· January 2024

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RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers.
Shanshan Tian, Xiaowei Zhong, Hui Wang, Jinhong Wei, Wenting Guo, Henry H Duff

Biochem J· September 2023

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Identification and in-silico characterization of splice-site variants from a large cardiogenetic national registry.
Kaveh Rayani, Brianna Davies, Matthew Cheung, Drake Comber, Jason D Roberts, Henry Duff

Eur J Hum Genet· May 2023

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The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.
Meruyert Kudaibergenova, Jiqing Guo, Hanif M Khan, James Lees-Miller, Mahdi Mousaei, Henry J Duff

Biophys J· December 2022

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Return of Results Policies for Genomic Research: Current Practices and the Hearts in Rhythm Organization (HiRO) Approach.
Drake A Comber, Brianna Davies, Jason D Roberts, Rafik Tadros, Martin S Green, Henry Duff

Can J Cardiol· April 2022

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Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.
Kuo Hao Lee, Andrew D Fant, Jiqing Guo, Andy Guan, Joslyn Jung, Henry J Duff

J Chem Inf Model· September 2021

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Short-coupled ventricular fibrillation represents a distinct phenotype among latent causes of unexplained cardiac arrest: a report from the CASPER registry.
Christian Steinberg, Brianna Davies, Greg Mellor, Rafik Tadros, Zachary W Laksman, Henry Duff

Eur Heart J· July 2021

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Lipid regulation of hERG1 channel function.
Williams E Miranda, Jiqing Guo, Haydee Mesa-Galloso, Valentina Corradi, James P Lees-Miller, Henry J Duff

Nat Commun· March 2021

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Refinement of a cryo-EM structure of hERG: Bridging structure and function.
Hanif M Khan, Jiqing Guo, Henry J Duff, D Peter Tieleman, Sergei Y Noskov

Biophys J· February 2021

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The Hearts in Rhythm Organization: A Canadian National Cardiogenetics Network.
Brianna Davies, Jason D Roberts, Rafik Tadros, Martin S Green, Jeffrey S Healey, Henry Duff

CJC Open· November 2020

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Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation.
Anna Janz, Ruping Chen, Martina Regensburger, Yuichiro Ueda, Simone Rost, Henry J Duff

Stem Cell Res· July 2020

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-Using the Gene to Reconstruct the Human LEMD2 Mutation Associated with Hutterite-type Cataract/Cardiomyopathy.
Ayaa AlKhaleefa, Frances L Snider, Henry J Duff, James D McGhee

MicroPubl Biol· June 2020

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Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade.
Meruyert Kudaibergenova, Jiqing Guo, Hanif M Khan, Farhan Zahid, James Lees-Miller, Henry J Duff

Front Pharmacol· June 2020

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Direct Effects of Empagliflozin on Extracellular Matrix Remodelling in Human Cardiac Myofibroblasts: Novel Translational Clues to Explain EMPA-REG OUTCOME Results.
Sean Kang, Subodh Verma, Ali Fatehi Hassanabad, Guoqi Teng, Darrell D Belke, Henry J Duff

Can J Cardiol· April 2020

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An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.
Jason D Roberts, S Yukiko Asaki, Andrea Mazzanti, J Martijn Bos, Izabela Tuleta, Henry J Duff

Circulation· February 2020

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Selectivity filter modalities and rapid inactivation of the hERG1 channel.
Williams E Miranda, Kevin R DeMarco, Jiqing Guo, Henry J Duff, Igor Vorobyov

Proc Natl Acad Sci U S A· February 2020

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A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources.
Divya C Kernik, Stefano Morotti, HaoDi Wu, Priyanka Garg, Henry J Duff

J Physiol· September 2019

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The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.
Laura Perissinotti, Jiqing Guo, Meruyert Kudaibergenova, James Lees-Miller, Marina Ol'khovich, Henry J Duff

Mol Pharmacol· August 2019

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Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy.
Andreas Brodehl, Saman Rezazadeh, Tatjana Williams, Nicole M Munsie, Daniel Liedtke, Henry J Duff

Transl Res· June 2019

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Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2.
Nelly Abdelfatah, Ruping Chen, Henry J Duff, Colette M Seifer, Ilan Buffo

JACC Basic Transl Sci· April 2019

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Early Repolarization Pattern Inheritance in the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER).
Navraj Malhi, Petsy P So, Christopher C Cheung, Zachary W M Laksman, Jeffrey S Healey, Henry Duff

JACC Clin Electrophysiol· November 2018

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Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.
Takanori Komada, Hyunjae Chung, Arthur Lau, Jaye M Platnich, Paul L Beck, Henry J Duff

J Am Soc Nephrol· April 2018

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Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.
Laura L Perissinotti, Pablo M De Biase, Jiqing Guo, Pei-Chi Yang, Miranda C Lee, Henry J Duff

Front Physiol· April 2018

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Randomized Crossover Trial of Blood Volume Monitoring-Guided Ultrafiltration Biofeedback to Reduce Intradialytic Hypotensive Episodes with Hemodialysis.
Kelvin C W Leung, Robert R Quinn, Pietro Ravani, Henry Duff, Jennifer M MacRae

Clin J Am Soc Nephrol· November 2017

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