Publications by authors named "Henry Gu"

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Profiling microRNAs through development of the parasitic nematode Haemonchus identifies nematode-specific miRNAs that suppress larval development.
Neil D Marks, Alan D Winter, Henry Y Gu, Kirsty Maitland, Victoria Gillan

Sci Rep· November 2019

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Increased Expression of a MicroRNA Correlates with Anthelmintic Resistance in Parasitic Nematodes.
Victoria Gillan, Kirsty Maitland, Roz Laing, Henry Gu, Neil D Marks

Front Cell Infect Microbiol· July 2018

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Conservation of a microRNA cluster in parasitic nematodes and profiling of miRNAs in excretory-secretory products and microvesicles of Haemonchus contortus.
Henry Y Gu, Neil D Marks, Alan D Winter, William Weir, Thomas Tzelos

PLoS Negl Trop Dis· November 2017

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Application of small RNA technology for improved control of parasitic helminths.
Collette Britton, Alan D Winter, Neil D Marks, Henry Gu, Tom N McNeilly

Vet Parasitol· August 2015

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Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).
Scott H Watterson, Ping Chen, Yufen Zhao, Henry H Gu, T G Murali Dhar

J Med Chem· July 2007

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Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.
Ping Chen, Arthur M Doweyko, Derek Norris, Henry H Gu, Steven H Spergel

J Med Chem· August 2004

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3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
T G Murali Dhar, Zhongqi Shen, Henry H Gu, Ping Chen, Derek Norris

Bioorg Med Chem Lett· October 2003

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Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
Edwin J Iwanowicz, Scott H Watterson, Junqing Guo, William J Pitts, T G Murali Dhar, Henry H Gu

Bioorg Med Chem Lett· June 2003

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Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Scott H Watterson, Marianne Carlsen, T G Murali Dhar, Zhongqi Shen, William J Pitts, Junqing Guo, Henry H Gu

Bioorg Med Chem Lett· February 2003

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Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
T G Murali Dhar, Scott H Watterson, Ping Chen, Zhongqi Shen, Henry H Gu, Junqing Guo

Bioorg Med Chem Lett· February 2003

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A survey of cyclic replacements for the central diamide moiety of inhibitors of inosine monophosphate dehydrogenase.
T G Murali Dhar, Chunjian Liu, William J Pitts, Junquing Guo, Scott H Watterson, Henry Gu

Bioorg Med Chem Lett· November 2002

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Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency.
Ping Chen, Edwin J Iwanowicz, Derek Norris, Henry H Gu, James Lin

Bioorg Med Chem Lett· November 2002

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Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase.
Scott H Watterson, Chunjian Liu, T G Murali Dhar, Henry H Gu, William J Pitts

Bioorg Med Chem Lett· October 2002

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Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.
Edwin J Iwanowicz, Scott H Watterson, Chunjian Liu, Henry H Gu, Toomas Mitt

Bioorg Med Chem Lett· October 2002

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Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.
William J Pitts, Junqing Guo, T G Murali Dhar, Zhongqi Shen, Henry H Gu

Bioorg Med Chem Lett· August 2002

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A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues.
T G Murali Dhar, Junqing Guo, Zhongqi Shen, William J Pitts, Henry H Gu

Org Lett· June 2002

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Novel diamide-based inhibitors of IMPDH.
Henry H Gu, Edwin J Iwanowicz, Junqing Guo, Scott H Watterson, Zhongqi Shen

Bioorg Med Chem Lett· May 2002

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Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).
Ping Chen, Derek Norris, Edwin J Iwanowicz, Steven H Spergel, James Lin, Henry H Gu

Bioorg Med Chem Lett· May 2002

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Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
T G Murali Dhar, Zhongqi Shen, Junqing Guo, Chunjian Liu, Scott H Watterson, Henry H Gu

J Med Chem· May 2002

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