Publications by authors named "Hermann Gram"

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Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis.
Jan Hettwer, Julia Hinterdobler, Benedikt Miritsch, Marcus-André Deutsch, Xinghai Li, Hermann Gram

Cardiovasc Res· October 2022

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A dysregulated interleukin-18-interferon-γ-CXCL9 axis impacts treatment response to canakinumab in systemic juvenile idiopathic arthritis.
Tanja Hinze, Christoph Kessel, Claas H Hinze, Julia Seibert, Hermann Gram

Rheumatology (Oxford)· November 2021

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The long and winding road in pharmaceutical development of canakinumab from rare genetic autoinflammatory syndromes to myocardial infarction and cancer.
Hermann Gram

Pharmacol Res· April 2020

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Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis.
Amélie Vromman, Victoria Ruvkun, Eugenia Shvartz, Gregory Wojtkiewicz, Gustavo Santos Masson, Hermann Gram

Eur Heart J· August 2019

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Combination Therapy for Treating Advanced Drug-Resistant Acute Lymphoblastic Leukemia.
Yorleny Vicioso, Hermann Gram, Rose Beck, Abhishek Asthana, Keman Zhang

Cancer Immunol Res· July 2019

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Treatment of primary Sjögren's syndrome with ianalumab (VAY736) targeting B cells by BAFF receptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity.
Thomas Dörner, Maximilian Georg Posch, Yue Li, Olivier Petricoul, Maciej Cabanski, Hermann Gram

Ann Rheum Dis· May 2019

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Neutralization of Interleukin-1β following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes.
Johanna Flygt, Karsten Ruscher, Amanda Norberg, Anis Mir, Hermann Gram

J Neurotrauma· December 2018

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Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice.
Delphine Gomez, Richard A Baylis, Brittany G Durgin, Alexandra A C Newman, Gabriel F Alencar, Hermann Gram

Nat Med· September 2018

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An Activating Janus Kinase-3 Mutation Is Associated with Cytotoxic T Lymphocyte Antigen-4-Dependent Immune Dysregulation Syndrome.
Heiko Sic, Matthaios Speletas, Vanessa Cornacchione, Maximillian Seidl, Martin Beibel, Hermann Gram

Front Immunol· December 2017

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Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy.
Arndt H Brachat, Alexei A Grom, Nico Wulffraat, Hermine I Brunner, Pierre Quartier, Hermann Gram

Arthritis Res Ther· January 2017

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Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis.
Tassili A F Weehuizen, Jacqueline M Lankelma, Hanna K De Jong, Onno J De Boer, Joris J T H Roelofs, Hermann Gram

Shock· November 2016

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The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β.
Jean-Michel Rondeau, Paul Ramage, Mauro Zurini, Hermann Gram

MAbs· August 2016

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Preclinical characterization and clinical development of ILARIS(®) (canakinumab) for the treatment of autoinflammatory diseases.
Hermann Gram

Curr Opin Chem Biol· June 2016

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Diffuse traumatic axonal injury in mice induces complex behavioural alterations that are normalized by neutralization of interleukin-1β.
Sara Ekmark-Lewén, Johanna Flygt, Gudrun A Fridgeirsdottir, Olivia Kiwanuka, Anders Hånell, Hermann Gram

Eur J Neurosci· April 2016

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Reducing Vascular Calcification by Anti-IL-1β Monoclonal Antibody in a Mouse Model of Familial Hypercholesterolemia.
Zuhier Awan, Maxime Denis, Anna Roubtsova, Rachid Essalmani, Jadwiga Marcinkiewicz, Hermann Gram

Angiology· February 2016

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Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.
Nadejda L Korneeva, Anren Song, Hermann Gram, Mary Ann Edens, Robert E Rhoads

J Biol Chem· February 2016

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Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes.
Nanguneri Nirmala, Alexei Grom, Hermann Gram

Curr Opin Rheumatol· September 2014

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Effector-mediated eradication of precursor B acute lymphoblastic leukemia with a novel Fc-engineered monoclonal antibody targeting the BAFF-R.
Reshmi Parameswaran, Min Lim, Fei Fei, Hisham Abdel-Azim, Anna Arutyunyan, Hermann Gram

Mol Cancer Ther· June 2014

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Pharmacokinetics, biocompatibility and bioavailability of a controlled release monoclonal antibody formulation.
Daniel Schweizer, Igor Vostiar, Annabelle Heier, Tim Serno, Karin Schoenhammer, Hermann Gram

J Control Release· December 2013

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Pharmacokinetic and pharmacodynamic properties of canakinumab, a human anti-interleukin-1β monoclonal antibody.
Abhijit Chakraborty, Stacey Tannenbaum, Christiane Rordorf, Philip J Lowe, David Floch, Hermann Gram

Clin Pharmacokinet· June 2012

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Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis.
Adam Denes, Caroline Drake, Jing Stordy, Janet Chamberlain, Barry W McColl, Hermann Gram

J Am Heart Assoc· June 2012

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Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice.
Fredrik Clausen, Anders Hånell, Charlotte Israelsson, Johanna Hedin, Ted Ebendal, Hermann Gram

Eur J Neurosci· July 2011

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Mnk mediates integrin α6β4-dependent eIF4E phosphorylation and translation of VEGF mRNA.
Nadejda L Korneeva, Young Hwa Soung, Hong Im Kim, Anthony Giordano, Robert E Rhoads, Hermann Gram

Mol Cancer Res· December 2010

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Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice.
Fredrik Clausen, Anders Hånell, Maria Björk, Lars Hillered, Anis K Mir, Hermann Gram

Eur J Neurosci· August 2009

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The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.
Magdalena Koziczak-Holbro, Amanda Littlewood-Evans, Bernadette Pöllinger, Jiri Kovarik, Janet Dawson, Hermann Gram

Arthritis Rheum· June 2009

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